Zobrazeno 1 - 10
of 58
pro vyhledávání: '"G, Todderud"'
Publikováno v:
Mediators of Inflammation, Vol 3, Iss 6, Pp 459-463 (1994)
The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interac
Externí odkaz:
https://doaj.org/article/f9b43aa2b7424085b095a04bd32f6595
Publikováno v:
Mediators of Inflammation, Vol 3, Iss 6, Pp 459-463 (1994)
Mediators of Inflammation
Mediators of Inflammation
The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81919d8c89868f99a1103853e1dd8cf5
https://doaj.org/article/f9b43aa2b7424085b095a04bd32f6595
https://doaj.org/article/f9b43aa2b7424085b095a04bd32f6595
Publikováno v:
Journal of Biological Chemistry. 268:3357-3363
Activated phagocytes produce large amounts of reactive oxygen intermediates, including peroxides. In addition to their microbicidal effect, it has recently been suggested that reactive oxygen species play a role as intracellular messengers. The mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae6e09cab44f615b89e898522132dffa
https://doi.org/10.1016/s0021-9258(18)53702-9
https://doi.org/10.1016/s0021-9258(18)53702-9
Autor:
A, Marinier, A, Martel, C, Bachand, S, Plamondon, B, Turmel, J P, Daris, J, Banville, P, Lapointe, C, Ouellet, P, Dextraze, M, Menard, J J, Wright, J, Alford, D, Lee, P, Stanley, X, Nair, G, Todderud, K M, Tramposch
Publikováno v:
Bioorganicmedicinal chemistry. 9(6)
A series of potent inhibitors of P-selectin as potential anti-inflammatory agents is reported. These compounds are derivatives of galactocerebrosides bearing a malonate side chain in positions 2 and 3 of the galactose moiety. Based on the binding mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4bfa241f491c81ae323a51a6f8272a4
https://pubmed.ncbi.nlm.nih.gov/11408160
https://pubmed.ncbi.nlm.nih.gov/11408160
Autor:
G, Todderud, X, Nair, D, Lee, J, Alford, L, Davern, P, Stanley, C, Bachand, P, Lapointe, A, Marinier, A, Martel, M, Menard, J J, Wright, J, Bajorath, D, Hollenbaugh, A, Aruffo, K M, Tramposch
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(3)
Selectin binding is the first step in extravasation of leukocytes through the endothelium. Infiltration of leukocytes is a hallmark of an inflammatory response. Blockade of selectin-dependent adhesion, therefore, represents a specific mechanism-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a552d744acf41957aed1fe677c86798d
https://pubmed.ncbi.nlm.nih.gov/9316838
https://pubmed.ncbi.nlm.nih.gov/9316838
Publikováno v:
Cancer research. 52(16)
We have examined the distribution of phospholipase C-gamma 1 (PLC-gamma 1) between membrane and cytosolic fractions in several cell lines. In MDA-468 cells, which are derived from a human breast tumor, greater than one-half of the total PLC-gamma 1 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fd7a7e9b485f6b2b42306ea159dcec2
https://pubmed.ncbi.nlm.nih.gov/1643644
https://pubmed.ncbi.nlm.nih.gov/1643644
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 3(4)
Phospholipase C-gamma 1 (PLC-gamma 1) is a well characterized substrate for the epidermal growth factor receptor tyrosine kinase and has been implicated in the intracellular biochemical signaling cascade which occurs following stimulation of cells wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ee2be295a8c5c1de8a4fa7ca871324b
https://pubmed.ncbi.nlm.nih.gov/1515369
https://pubmed.ncbi.nlm.nih.gov/1515369
Publikováno v:
Ciba Foundation symposium. 164
The hydrolysis of phosphatidylinositol 4,5-bisphosphate has a central role in many signalling pathways. One of the phospholipase C (PLC) isozymes that mediates this reaction is a direct substrate for the tyrosine kinase activity of several growth fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73526c4499a6bf1f581e1045d68a8047
https://pubmed.ncbi.nlm.nih.gov/1395933
https://pubmed.ncbi.nlm.nih.gov/1395933
Publikováno v:
Advances in experimental medicine and biology. 231
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f942b36b762707afac73b338ef6d3592
https://pubmed.ncbi.nlm.nih.gov/3046253
https://pubmed.ncbi.nlm.nih.gov/3046253
Autor:
G, Todderud, G, Carpenter
Publikováno v:
BioFactors (Oxford, England). 2(1)
Epidermal growth factor (EGF) is a small polypeptide hormone with mitogenic properties in vivo and in vitro. EGF elicits biologic responses by binding to a cell surface receptor which is a transmembrane glycoprotein containing a cytoplasmic protein t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::952148a57a6824fc043865a8a84acceb
https://pubmed.ncbi.nlm.nih.gov/2553047
https://pubmed.ncbi.nlm.nih.gov/2553047