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Hyperthyroxinemia with a non-suppressed TSH: how to confidently reach a diagnosis in this clinical conundrum

Autor: B Mukhopadhyay, J G Timmons

Publikováno v: Hormones (Athens, Greece)

Disorders of thyroid function are among the commonest referrals to endocrinology. While interpretation of thyroid function testing is usually straightforward, accurate interpretation becomes significantly more challenging when the parameters do not b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4721ea7c3754ccf6888fdf3f80156441
https://doi.org/10.1007/s42000-020-00180-3

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Cognitive impairment reversed by cinacalcet administration in primary hyperparathyroidism

Autor: Joseph G. Timmons, M. Bailey, C. McDougall, R. Manners

Publikováno v: Hormones (Athens, Greece)

Primary hyperparathyroidism (pHPT) is a common endocrine disorder. Often serum calcium is minimally elevated with few symptoms. In elderly patients with multiple co-morbidities, the decision to “watch and wait” is often most clinically appropriat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06281b9f360409114b3cad4777c58f27
http://europepmc.org/articles/PMC8357729

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Time in Range as a Research Outcome Measure

Autor: James G. Boyle, Joseph G. Timmons, John R. Petrie

Publikováno v: Diabetes Spectr

Time in range (TIR) is gaining ground as an outcome measure in type 1 diabetes trials. However, inclusion of TIR raises several issues for trial design. In this article, the authors begin by defining TIR and describing the current international conse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e520c341ec843fdbfdd93b53458b0e92
https://pubmed.ncbi.nlm.nih.gov/34149253

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Metformin and carotid intima media thickness in never smokers with type 1 diabetes:the REMOVAL trial

Autor: Martijn C. G. J. Brouwers, Helen M. Colhoun, Therese Tillin, Naveed Sattar, Teik Chye Ooi, Ian Ford, Peter Rossing, Alicia J. Jenkins, Irene Hramiak, Alun D. Hughes, John R. Petrie, Nish Chaturvedi, Ronald Klein, Barbara E.K. Klein, James G. Boyle, Joseph G. Timmons, Coen D.A. Stehouwer, Nicola Greenlaw

Publikováno v: Timmons, J G & REMOVAL Study Group 2021, ' Metformin and carotid intima media thickness in never smokers with type 1 diabetes : the REMOVAL trial ', Diabetes, Obesity and Metabolism, vol. 23, no. 6, pp. 1371-1378 . https://doi.org/10.1111/dom.14350
Diabetes Obesity & Metabolism, 23(6), 1371-1378. Wiley
2021, ' Metformin and carotid intima-media thickness in never-smokers with type 1 diabetes : The REMOVAL trial ', Diabetes, Obesity and Metabolism, vol. 23, no. 6, pp. 1371-1378 . https://doi.org/10.1111/dom.14350

AimTo determine whether metformin's effects on carotid artery intima-media thickness (cIMT) in type 1 diabetes differ according to smoking status.MethodsRegression model effect estimates for the effect of metformin versus placebo (double-blind) on ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda6e541696bc840f97305f44daff48e
https://curis.ku.dk/ws/files/273588866/dom.14350.pdf

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490-P: Renal Effects of Metformin in Type 1 Diabetes (T1D): The REMOVAL Trial

Autor: Paul Welsh, Alun D. Hughes, Naveed Sattar, Coen D.A. Stehouwer, Martijn C. G. J. Brouwers, Alicia J. Jenkins, Irene Hramiak, Nicola Greenlaw, John R. Petrie, Nishi Chaturvedi, Peter Rossing, Joseph G. Timmons, Helen M. Colhoun

Publikováno v: Diabetes. 69

Aims: In REMOVAL (NCT01483560), metformin attenuated decline in estimated glomerular filtration rate (eGFR) using the creatinine-based Modified Diet in Renal Disease (MDRD) equation in adults with T1D. We now report the effects of metformin vs. place

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d93cdf79c6048c83ebc437b2f7e948e
https://doi.org/10.2337/db20-490-p

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Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

Autor: R. Holland, Ana Rubio-Araiz, Virginia Mela, Marina A. Lynch, Yurii K. Gun'ko, A. McIntosh, Sarah A McCarthy, G. Timmons, Orla M. Finucane

Publikováno v: Brain, Behavior, and Immunity. 68:183-196

Microglia, like macrophages, can adopt inflammatory and anti-inflammatory phenotypes depending on the stimulus. In macrophages, the evidence indicates that these phenotypes have different metabolic profiles with lipopolysaccharide (LPS)- or interfero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2ffdad807d70a170f717f1f94c89aa
https://doi.org/10.1016/j.bbi.2017.10.017

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Axillary Artery Injury with Intact Radial Pulse following Fracture-Dislocation of Shoulder: A Case Report

Autor: A Rajeev, G Timmons

Publikováno v: Malaysian Orthopaedic Journal, Vol 13, Iss 3, Pp 66-68 (2019)
Malaysian Orthopaedic Journal

The occurrence of axillary artery injury following proximal humerus fracture dislocation in elderly patient with low velocity fall is uncommon. The patient could have diverse clinical presentations in spite of intact peripheral pulses. We report the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb2a08324f7cf9545bac8a1b45d7daf
https://doi.org/10.5704/moj.1911.011

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