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Akademický článek

Investigating how HIV-1 antiretrovirals differentially behave as substrates and inhibitors of P-glycoprotein via molecular dynamics simulations

Autor: Daisy I. Fuchs, Lauren D. Serio, Sahana Balaji, Kayla G. Sprenger

Publikováno v: Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2669-2679 (2024)

HIV-1 can rapidly infect the brain upon initial infection, establishing latent reservoirs that induce neuronal damage and/or death, resulting in HIV-Associated Neurocognitive Disorder. Though anti-HIV-1 antiretrovirals (ARVs) suppress viral load, the

Externí odkaz: https://doaj.org/article/16081dd8318742cfaf5225af558840bb

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Akademický článek

Common framework mutations impact antibody interfacial dynamics and flexibility

Autor: Emily R. Rhodes, Jonathan G. Faris, Brian M. Petersen, Kayla G. Sprenger

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionWith the flood of engineered antibodies, there is a heightened need to elucidate the structural features of antibodies that contribute to specificity, stability, and breadth. While antibody flexibility and interface angle have begun to be

Externí odkaz: https://doaj.org/article/92fb3da14eb5413e943634e81846d800

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Akademický článek

Moving the needle: Employing deep reinforcement learning to push the boundaries of coarse-grained vaccine models

Autor: Jonathan G. Faris, Daniel Orbidan, Charles Wells, Brenden K. Petersen, Kayla G. Sprenger

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Highly mutable infectious disease pathogens (hm-IDPs) such as HIV and influenza evolve faster than the human immune system can contain them, allowing them to circumvent traditional vaccination approaches and causing over one million deaths annually.

Externí odkaz: https://doaj.org/article/e0d0a5d75cbe40ce8d3ab11f03f9d3fe

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Akademický článek

Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV

Autor: Simone Conti, Victor Ovchinnikov, Jonathan G. Faris, Arup K. Chakraborty, Martin Karplus, Kayla G. Sprenger

Publikováno v: PLoS Computational Biology, Vol 18, Iss 4 (2022)

The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system responds to encountering multiple variant antigens (Ags). Here, we describe a multiscale model of

Externí odkaz: https://doaj.org/article/1fb711c145304bb7a7da516379116abf

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Akademický článek

Regulatory Approved Monoclonal Antibodies Contain Framework Mutations Predicted From Human Antibody Repertoires

Autor: Brian M. Petersen, Sophia A. Ulmer, Emily R. Rhodes, Matias F. Gutierrez-Gonzalez, Brandon J. Dekosky, Kayla G. Sprenger, Timothy A. Whitehead

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Monoclonal antibodies (mAbs) are an important class of therapeutics used to treat cancer, inflammation, and infectious diseases. Identifying highly developable mAb sequences in silico could greatly reduce the time and cost required for therapeutic mA

Externí odkaz: https://doaj.org/article/10a36cfa20ad4ada87c052c6b7e5c904

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Akademický článek

Yield of yearly routine physical examination in HIV-1 infected patients is limited: A retrospective cohort study in the Netherlands.

Autor: Marleen A van Amsterdam, Sander van Assen, Herman G Sprenger, Kasper R Wilting, Ymkje Stienstra, Wouter F W Bierman

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0179539 (2017)

Routine physical examinations might be of value in HIV-infected patients, but the yield is unknown. We determined the diagnoses that would have been missed without performing annual routine physical examinations in HIV-infected patients with stable d

Externí odkaz: https://doaj.org/article/1c1b14b6e99443269da3d054ddb91b7b

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