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Akademický článek
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Akademický článek
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Autor:
C. Ladbury, A. Rincon, J. Song, S. Armenian, A. Liu, R. Spielberger, L. Popplewell, F. Sahebi, P. Parker, S. Forman, D. Snyder, A. Dagis, P. Frankel, D. Yang, J. Wong, G. Somlo
Publikováno v:
Radiotherapy and Oncology. 170:S992-S993
Autor:
Enrique Soto-Perez-de-Celis, Joanne E. Mortimer, Arnold Rotter, Yuan Yuan, Daneng Li, Christina Yeon, Suzette Blanchard, Rachel Morrison, Vani Katheria, Nimit Sudan, Samuel Chung, J Waisman, Arti Hurria, Jennifer Choi, Ty Lee, Abrahm Levi, Thehang H. Luu, G. Somlo, Anne M. Noonan, Peggy Burhenn, Andrea Rubalcava, Anait Arsenyan
Publikováno v:
Clin Breast Cancer
Introduction Phase II clinical trials including geriatric assessment (GA) measures are critical for improving the evidence base for older adults with cancer. We assessed the efficacy and tolerability of nab-paclitaxel in older adults with metastatic
Publikováno v:
Cancer Research. 79:P6-21
Background No targeted therapies have been approved for triple negative breast cancer (TNBC) thus far. Retinoblastoma protein (pRb), a major substrate of cyclin-dependent kinase (CDK) 4/6, might be a potential target especially in chemoresistant TNBC
Publikováno v:
Cancer Research. 79:P3-06
Background. We recently described six distinct genomic configurations characterized by large numbers of distributed somatic tandem duplications (TDs) known as Tandem Duplicator Phenotypes (TDPs). Different TDPs feature TDs of different span sizes, an
Autor:
Kemeberly Charles, Laura Kruper, D Mitani, Joanne E. Mortimer, Arti Hurria, C Uranga, I Paredero-Perez, Enrique Soto-Perez-de-Celis, Heeyoung Kim, Jessica Vazquez, Jeanine Moreno, Lesley Taylor, NH Patel, Vani Katheria, Elsa Roberts, G. Somlo, Yexian Yuan, Abrahm Levi, C-L Sun, J Waisman
Publikováno v:
Cancer Research. 79:P6-16
Background: Almost a quarter of older adults in the United States will identify themselves as Hispanic/Latino by 2060. Our group has previously developed and validated a self-administered geriatric assessment tool which can be used to identify functi
Autor:
T Luu, Aileen Tang, Joanne E. Mortimer, G. Somlo, Arti Hurria, N Tank Patel, J Waisman, Susan E. Yost, Yexian Yuan, Norma Martinez, M Li, Jana Portnow, Kim Robinson, H Yin, Lucille Leong, Suzette Blanchard
Publikováno v:
Cancer Research. 79:P6-18
Background: Alteration of PI3K/Akt/mTOR pathway is the most common genomic abnormality detected in triple negative breast cancer (TNBC). Everolimus acts synergistically with eribulin in inducing apoptosis in TNBC cell lines and xenografts in our prec
Autor:
J Waisman, Joanne E. Mortimer, Arti Hurria, Daniel Schmolze, John H. Yim, T Treece, Y Yuan, Laura Kruper, Lusine Tumyan, M Li, Veronica Jones, Christina Yeon, Paul Frankel, G. Somlo
Publikováno v:
Cancer Research. 79:P1-15
Background: Response to neoadjuvant therapy (NT) predicts progression-free and overall survival in triple negative breast cancer (TNBC). Carboplatin has shown efficacy in patients with TNBC. The current phase II prospective neoadjuvant trial was desi
Autor:
J Waisman, Daniel Schmolze, Norma Martinez, Aileen Tang, G. Somlo, Susan E. Yost, Peter P. Lee, S Apple, B Mendez, Mina S. Sedrak, Joanne E. Mortimer, N Tank, Paul Frankel, Timothy W. Synold, Yate-Ching Yuan, Arti Hurria
Publikováno v:
Cancer Research. 78:OT1-05
Background: Androgen receptor (AR) targeted therapy and immunotherapy represent one of the most promising strategies for metastatic triple negative breast cancer (mTNBC), which accounts for 15-20% of all breast cancers. As a nonsteroidal selective an