Zobrazeno 1 - 10
of 813
pro vyhledávání: '"G, Snell"'
Autor:
Thomas J. Lopdell, Alexander J. Trevarton, Janelle Moody, Claire Prowse-Wilkins, Sarah Knowles, Kathryn Tiplady, Amanda J. Chamberlain, Michael E. Goddard, Richard J. Spelman, Klaus Lehnert, Russell G. Snell, Stephen R. Davis, Mathew D. Littlejohn
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-18 (2024)
Abstract Background Bovine lactoferrin (Lf) is an iron absorbing whey protein with antibacterial, antiviral, and antifungal activity. Lactoferrin is economically valuable and has an extremely variable concentration in milk, partly driven by environme
Externí odkaz:
https://doaj.org/article/8080a82b88cf4f85b058bde3a2e3767d
Autor:
Jessie Poquérusse, Melinda Nolan, David R. Thorburn, Johan L. K. Van Hove, Marisa W. Friederich, Donald R. Love, Juliet Taylor, Christopher A. Powell, Michal Minczuk, Russell G. Snell, Klaus Lehnert, Emma Glamuzina, Jessie C. Jacobsen
Publikováno v:
JIMD Reports, Vol 64, Iss 3, Pp 223-232 (2023)
Abstract Disorders of mitochondrial function are a collectively common group of genetic diseases in which deficits in core mitochondrial translation machinery, including aminoacyl tRNA synthetases, are key players. Biallelic variants in the CARS2 gen
Externí odkaz:
https://doaj.org/article/4f5342b87e7f4e589989796569d7e800
Autor:
Victoria J Sugrue, Joseph Alan Zoller, Pritika Narayan, Ake T Lu, Oscar J Ortega-Recalde, Matthew J Grant, C Simon Bawden, Skye R Rudiger, Amin Haghani, Donna M Bond, Reuben R Hore, Michael Garratt, Karen E Sears, Nan Wang, Xiangdong William Yang, Russell G Snell, Timothy A Hore, Steve Horvath
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/3a91ff2b152a430ebb04aa6413d17d2f
Autor:
Whitney Whitford, Victoria Hawkins, Kriebashne S. Moodley, Matthew J. Grant, Klaus Lehnert, Russell G. Snell, Jessie C. Jacobsen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Rapid, cost-effective identification of genetic variants in small candidate genomic regions remains a challenge, particularly for less well equipped or lower throughput laboratories. The application of Oxford Nanopore Technologies’ MinION
Externí odkaz:
https://doaj.org/article/e43a767705bc46fe97e5a6b6fdc8be28
Autor:
Stephen R. Davis, Hamish E. Ward, Van Kelly, David Palmer, Alexandra E. Ankersmit-Udy, Thomas J. Lopdell, Sarah D. Berry, Mathew D. Littlejohn, Kathryn Tiplady, Linda F. Adams, Katie Carnie, Alayna Burrett, Natalie Thomas, Russell G. Snell, Richard J. Spelman, Klaus Lehnert
Publikováno v:
Genetics Selection Evolution, Vol 54, Iss 1, Pp 1-11 (2022)
Abstract Background Milk samples from 10,641 dairy cattle were screened by a mass spectrometry method for extreme concentrations of the A or B isoforms of the whey protein, β-lactoglobulin (BLG), to identify causative genetic variation driving chang
Externí odkaz:
https://doaj.org/article/460d3305b076430b8ce7ce75746098c0
Autor:
Andrew Jiang, Alex Ankersmit-Udy, Sally-Anne Turner, Megan Scholtens, Mathew D. Littlejohn, Nicolas Lopez-Villalobos, Colin G. Proser, Russell G. Snell, Klaus Lehnert
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 13, Iss 1, Pp 1-10 (2022)
Abstract Background Economically important milk production traits including milk volume, milk fat and protein yield vary considerably across dairy goats in New Zealand. A significant portion of the variation is attributable to genetic variation. Disc
Externí odkaz:
https://doaj.org/article/37111db90e9f4fd280d879d1c31e449d
DNA methylation study of Huntington’s disease and motor progression in patients and in animal models
Autor:
Ake T. Lu, Pritika Narayan, Matthew J. Grant, Peter Langfelder, Nan Wang, Seung Kwak, Hilary Wilkinson, Richard Z. Chen, Jian Chen, C. Simon Bawden, Skye R. Rudiger, Marc Ciosi, Afroditi Chatzi, Alastair Maxwell, Timothy A. Hore, Jeff Aaronson, Jim Rosinski, Alicia Preiss, Thomas F. Vogt, Giovanni Coppola, Darren Monckton, Russell G. Snell, X. William Yang, Steve Horvath
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Although Huntington’s disease (HD) is a well-studied genetic disorder, less is known about the epigenetic changes underlying it. Here, the authors characterize DNA methylation levels in tissues from patients, a mouse huntingtin (Htt) gene knock-in
Externí odkaz:
https://doaj.org/article/9415f3c0bb6441ffad6d13aeb09b8ee8
Autor:
Tania Fink, Thomas J. Lopdell, Kathryn Tiplady, Renee Handley, Thomas J. J. Johnson, Richard J. Spelman, Stephen R. Davis, Russell G. Snell, Mathew D. Littlejohn
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background The DGAT1 gene encodes an enzyme responsible for catalysing the terminal reaction in mammary triglyceride synthesis, and underpins a well-known pleiotropic quantitative trait locus (QTL) with a large influence on milk composition
Externí odkaz:
https://doaj.org/article/c12b3a625ee1495d8ea1c2bf4fc75c90
Autor:
Victoria J Sugrue, Joseph Alan Zoller, Pritika Narayan, Ake T Lu, Oscar J Ortega-Recalde, Matthew J Grant, C Simon Bawden, Skye R Rudiger, Amin Haghani, Donna M Bond, Reuben R Hore, Michael Garratt, Karen E Sears, Nan Wang, Xiangdong William Yang, Russell G Snell, Timothy A Hore, Steve Horvath
Publikováno v:
eLife, Vol 10 (2021)
In mammals, females generally live longer than males. Nevertheless, the mechanisms underpinning sex-dependent longevity are currently unclear. Epigenetic clocks are powerful biological biomarkers capable of precisely estimating chronological age and
Externí odkaz:
https://doaj.org/article/901ed9d95cff4307a781c381e14cdfb3
Autor:
Swati Jivanji, Gemma Worth, Thomas J. Lopdell, Anna Yeates, Christine Couldrey, Edwardo Reynolds, Kathryn Tiplady, Lorna McNaughton, Thomas J. J. Johnson, Stephen R. Davis, Bevin Harris, Richard Spelman, Russell G. Snell, Dorian Garrick, Mathew D. Littlejohn
Publikováno v:
Genetics Selection Evolution, Vol 51, Iss 1, Pp 1-18 (2019)
Abstract Background White spotting of the coat is a characteristic trait of various domestic species including cattle and other mammals. It is a hallmark of Holstein–Friesian cattle, and several previous studies have detected genetic loci with majo
Externí odkaz:
https://doaj.org/article/4182bd4389d749efa8e40b3f86fe123a