Zobrazeno 1 - 10
of 150
pro vyhledávání: '"G, Siemeister"'
Publikováno v:
Hormone Replacement Therapy and Cancer ISBN: 9781003076469
Hormone Replacement Therapy and Cancer
Hormone Replacement Therapy and Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2449871f924ac433d731da706e6aa3ee
https://doi.org/10.1201/9781003076469-32
https://doi.org/10.1201/9781003076469-32
Autor:
Roland Neuhaus, Ingo V. Hartung, G. Siemeister, Marion Hitchcock, Arne Scholz, Stefanie Hammer, Dominic Brittain, Kirstin Petersen, Roman C. Hillig, Florian Pühler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2384-2390
Using PD325901 as a starting point for identifying novel allosteric MEK inhibitors with high cell potency and long-lasting target inhibition in vivo, truncation of its hydroxamic ester headgroup was combined with incorporation of alkyl and aryl ether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906a87ca708db061bad0c419e3d20d92
https://doi.org/10.1016/j.bmcl.2013.02.028
https://doi.org/10.1016/j.bmcl.2013.02.028
Autor:
C. Ruehl-Fehlert, L. Baerfaker, H.M. Himmel, G. Siemeister, A. Borgne-Sanchez, S. Prechtl, Marian Raschke, R. Zierz
Publikováno v:
Toxicology Letters. 295:S30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10aed7cf7f7df8744b25dd6184504ecd
https://doi.org/10.1016/j.toxlet.2018.06.1130
https://doi.org/10.1016/j.toxlet.2018.06.1130
Autor:
Florian Pühler, Arne Scholz, Roman C. Hillig, Ingo V. Hartung, Marion Hitchcock, G. Siemeister, Rolf Bohlmann, Stefanie Hammer, Roland Neuhaus
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(1)
Recently, we had identified an unexplored pocket adjacent to the known binding site of allosteric MEK inhibitors which allowed us to design highly potent and in vivo efficacious novel inhibitors. We now report that our initial preclinical candidate,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a653eef4df0b4c841fd02a76b7baaa
https://pubmed.ncbi.nlm.nih.gov/26611920
https://pubmed.ncbi.nlm.nih.gov/26611920
Autor:
Ingo V. Hartung, G. Siemeister, Roland Neuhaus, Marion Hitchcock, Jens Geisler, Oliver von Ahsen, Florian Pühler, Roman C. Hillig, Arne Scholz
Publikováno v:
ChemMedChem. 10(12)
Having recently identified a so-far unexplored area adjacent to the known binding site of allosteric mitogen-activated protein kinase kinase (MEK) inhibitors, we now report an extension of these studies by combining our new side chains with different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4dbe649f81e84e7362b12fb799c83b6
https://pubmed.ncbi.nlm.nih.gov/26541480
https://pubmed.ncbi.nlm.nih.gov/26541480
Autor:
A. Menrad, Dario Neri, G. Siemeister, L. Zardi, Christina Wagner, Hans D. Menssen, C. McCoy, Klaus Bosslet, Katharina Detjen
Publikováno v:
Falk Symposium ISBN: 9781402051098
Disease Progression and Disease Prevention in Hepatology and Gastroenterology
Disease Progression and Disease Prevention in Hepatology and Gastroenterology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1a0346c137afef42d7b2a1f67838fe
https://doi.org/10.1007/1-4020-5224-3_12
https://doi.org/10.1007/1-4020-5224-3_12
Autor:
Jens Geisler, Roman C. Hillig, Oliver von Ahsen, Florian Pühler, Ingo V. Hartung, Arne Scholz, Roland Neuhaus, Marion Hitchcock, G. Siemeister
Publikováno v:
ChemMedChem. 10:2116-2116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::718da23ca6ceffb8ef74bebc7c2c459e
https://doi.org/10.1002/cmdc.201500530
https://doi.org/10.1002/cmdc.201500530
Publikováno v:
Zeitschrift für Gastroenterologie. 43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4116c74c28e492c4c9d9720548741537
https://doi.org/10.1055/s-2005-920170
https://doi.org/10.1055/s-2005-920170
Publikováno v:
Angiogenesis. 4(2)
The transmembrane tyrosine kinase TIE-2, the receptor for the angiopoietins-1 and -2, has been shown to be involved in angiogenic processes. Investigating the regulation of TIE-2 expression on endothelial cells, we found that stimulators such as PMA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd73eb4a952edd825f2dd3bac88f008e
https://pubmed.ncbi.nlm.nih.gov/11806244
https://pubmed.ncbi.nlm.nih.gov/11806244
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