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Akademický článek

IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry

Autor: Peng Lu, Karolyn A. Oetjen, Diane E. Bender, Marianna B. Ruzinova, Daniel A. C. Fisher, Kevin G. Shim, Russell K. Pachynski, W. Nathaniel Brennen, Stephen T. Oh, Daniel C. Link, Daniel L. J. Thorek

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Multiplexed imaging technologies can reveal the complex cellular and molecular profiles of tissue. Here, the authors develop and implement a denoising pipeline to significantly enhance imaging mass cytometry quality and improve single-cell analyses.

Externí odkaz: https://doaj.org/article/4afb3a53b1ba47098abd1d17ba0fa669

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Akademický článek

Oncolytic virus-derived type I interferon restricts CAR T cell therapy

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Oncolytic viruses promote an inflammatory response and elicit anti-tumor immunity. Here the authors show, unexpectedly, that the oncolytic virus, VSVIFNβ, induces type I interferon responses that, when combined with chimeric antigen receptor (CAR) T

Externí odkaz: https://doaj.org/article/5178c922fdee4c4491424f98809482c4

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Akademický článek

APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

DNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine settin

Externí odkaz: https://doaj.org/article/0b522666697f4ba891fb72be5cba002f

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Akademický článek

Management of acute promyelocytic leukemia in the setting of acute COVID-19 infection

Autor: Kevin G Shim, Mallory Crain, Kristan Augustin, Karolyn A Oetjen

Publikováno v: Leukemia Research Reports, Vol 18, Iss , Pp 100353- (2022)

Acute promyelocytic leukemia (APL) often presents with significant coagulopathy which may result in both hemorrhagic and thrombotic complications. The emergence of the COVID-19 pandemic has complicated the initial treatment and diagnosis of APL owing

Externí odkaz: https://doaj.org/article/7aa71ae837fe4aa892e749de66013f32

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Akademický článek

APOBEC3 Mediates Resistance to Oncolytic Viral Therapy

Autor: Amanda L. Huff, Phonphimon Wongthida, Timothy Kottke, Jill M. Thompson, Christopher B. Driscoll, Matthew Schuelke, Kevin G. Shim, Reuben S. Harris, Amy Molan, Jose S. Pulido, Peter J. Selby, Kevin J. Harrington, Alan Melcher, Laura Evgin, Richard G. Vile

Publikováno v: Molecular Therapy: Oncolytics, Vol 11, Iss , Pp 1-13 (2018)

Tumor cells frequently evade applied therapies through the accumulation of genomic mutations and rapid evolution. In the case of oncolytic virotherapy, understanding the mechanisms by which cancer cells develop resistance to infection and lysis is cr

Externí odkaz: https://doaj.org/article/fd3503b7a0a047429514beaab62c3ec2

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Akademický článek

Diverse immunotherapies can effectively treat syngeneic brainstem tumors in the absence of overt toxicity

Autor: Matthew R. Schuelke, Phonphimon Wongthida, Jill Thompson, Timothy Kottke, Christopher B. Driscoll, Amanda L. Huff, Kevin G. Shim, Jose Pulido

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1 (2019)

BackgroundImmunotherapy has shown remarkable clinical promise in the treatment of various types of cancers. However, clinical benefits derive from a highly inflammatory mechanism of action. This presents unique challenges for use in pediatric brainst

Externí odkaz: https://doaj.org/article/5ae6f0f510a745349d500771354555cd

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