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Akademický článek

Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function

Autor: L. Grevendonk, N. J. Connell, C. McCrum, C. E. Fealy, L. Bilet, Y. M. H. Bruls, J. Mevenkamp, V. B. Schrauwen-Hinderling, J. A. Jörgensen, E. Moonen-Kornips, G. Schaart, B. Havekes, J. de Vogel-van den Bosch, M. C. E. Bragt, K. Meijer, P. Schrauwen, J. Hoeks

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Aging is associated with a progressive loss of muscle function. Here the authors characterize mitochondrial capacity and muscle function in young and older adults with similar habitual physical activity and also compared to older adults with exercise

Externí odkaz: https://doaj.org/article/035190f53f0041ab9013b063d3712f34

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Akademický článek

Outlook for coeliac disease patients: towards bread wheat with hypoimmunogenic gluten by gene editing of α- and γ-gliadin gene families

Autor: Aurélie Jouanin, Jan G. Schaart, Lesley A. Boyd, James Cockram, Fiona J. Leigh, Ruth Bates, Emma J. Wallington, Richard G. F. Visser, Marinus J. M. Smulders

Publikováno v: BMC Plant Biology, Vol 19, Iss 1, Pp 1-16 (2019)

Abstract Background Wheat grains contain gluten proteins, which harbour immunogenic epitopes that trigger Coeliac disease in 1–2% of the human population. Wheat varieties or accessions containing only safe gluten have not been identified and conven

Externí odkaz: https://doaj.org/article/ec879cd61e5f4dabb1d10e8128ce46c9

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Akademický článek

CRISPR/Cas9 Gene Editing of Gluten in Wheat to Reduce Gluten Content and Exposure—Reviewing Methods to Screen for Coeliac Safety

Autor: Aurelie Jouanin, Luud J. W. J. Gilissen, Jan G. Schaart, Fiona J. Leigh, James Cockram, Emma J. Wallington, Lesley A. Boyd, Hetty C. van den Broeck, Ingrid M. van der Meer, A. H. P. America, Richard Gerardus Franciscus Visser, Marinus J. M. Smulders

Publikováno v: Frontiers in Nutrition, Vol 7 (2020)

Ingestion of gluten proteins (gliadins and glutenins) from wheat, barley and rye can cause coeliac disease (CD) in genetically predisposed individuals. The only remedy is a strict and lifelong gluten-free diet. There is a growing desire for coeliac-s

Externí odkaz: https://doaj.org/article/3a56029ef3244eaa91bffc74db86a8f9

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Akademický článek

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Exploring the alpha‐gliadin locus: the 33‐mer peptide with six overlapping coeliac disease epitopes in Triticum aestivum is derived from a subgroup of Aegilops tauschii

Autor: Jan G. Schaart, Luud J.W.J. Gilissen, Danny Esselink, Elma M. J. Salentijn, Svetlana V. Goryunova, Nick Gosman, Marinus J. M. Smulders, Charity Chidzanga, Alison R. Bentley

Publikováno v: The Plant Journal
Plant Journal 106 (2021) 1
Plant Journal, 106(1), 86-94

Summary Most alpha‐gliadin genes of the Gli‐D2 locus on the D genome of hexaploid bread wheat (Triticum aestivum) encode for proteins with epitopes that can trigger coeliac disease (CD), and several contain a 33‐mer peptide with six partly over

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01fc5cf1db363cc9b26d98e7a3f315d
https://doi.org/10.1111/tpj.15147

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The biological feasibility and social context of gene-edited, caffeine-free coffee

Autor: Nils V. Leibrock, Joris Santegoets, Paul J. W. Mooijman, Filemon Yusuf, Xander C. L. Zuijdgeest, Esmée A. Zutt, Josette G. M. Jacobs, Jan G. Schaart

Publikováno v: Food Science and Biotechnology, 31(6), 635-655
Food Science and Biotechnology 31 (2022) 6

Coffee, especially the species Coffea arabica and Coffea canephora, is one of the world’s most consumed beverages. The consumer demand for caffeine-free coffee is currently being met through chemical decaffeination processes. However, this method l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a596181a9a6d3cf1ff27d839846d8685
https://research.wur.nl/en/publications/the-biological-feasibility-and-social-context-of-gene-edited-caff

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Akademický článek

Cisgenic apple trees; development, characterization and performance

Autor: Frans A. Krens, Jan G. Schaart, Aranka M. van der Burgh, Iris E.M. Tinnenbroek-Capel, Remmelt eGroenwold, Linda P. Kodde, Giovanni A.L. Broggini, Cesare eGessler, Henk J. Schouten

Publikováno v: Frontiers in Plant Science, Vol 6 (2015)

Two methods were developed for the generation of cisgenic apples. Both have been successfully applied producing trees. The first method avoids the use of any foreign selectable marker genes; only the gene-of-interest is integrated between the T-DNA b

Externí odkaz: https://doaj.org/article/0237ad941dff43cdba1de3cf163ba563

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Akademický článek

One-step Agrobacterium mediated transformation of eight genes essential for rhizobium symbiotic signaling using the novel binary vector system pHUGE.

Autor: Andreas Untergasser, Gerben J M Bijl, Wei Liu, Ton Bisseling, Jan G Schaart, René Geurts

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47885 (2012)

Advancement in plant research is becoming impaired by the fact that the transfer of multiple genes is difficult to achieve. Here we present a new binary vector for Agrobacterium tumefaciens mediated transformation, pHUGE-Red, in concert with a clonin

Externí odkaz: https://doaj.org/article/ba81a31d8c7940f7a936208938345a3e

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Akademický článek

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