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The regulation of Fas (CD95/Apo-1)-mediated liver apoptosis in Kupffer cell-depleted mice

Autor: Nympha B. D'Souza, Mariana Nikolova-Karakashian, Ion V. Deaciuc, Theodore G. Sarphie, Craig J. McClain, Willem J.S. de Villiers, Daniell B. Hill

Publikováno v: Hepatology Research. 24:192-204

The purpose of this study was to further characterize Fas-mediated liver apoptosis. We investigated whether Fas-mediated apoptosis in the liver requires induction of apoptosis-related regulators and whether Kupffer cells play a role in this process.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771d4c7283ff3aac13e768cac0da35ac
https://doi.org/10.1016/s1386-6346(02)00021-9

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Inhibition of Caspases In Vivo Protects the Rat Liver Against Alcohol-Induced Sensitization to Bacterial Lipopolysaccharide

Autor: Ravshan Burikhanov, Theodore G. Sarphie, Craig J. McClain, Nympha B. D'Souza, Willem J.S. de Villiers, Daniell B. Hill, Ion V. Deaciuc

Publikováno v: Alcoholism: Clinical and Experimental Research. 25:935-943

Background: The mechanisms of liver sensitization by alcohol to Gram-negative bacterial lipopolysaccharide (LPS) remain elusive. The purpose of this study was two-fold: (1) to test the hypothesis that alcohol-enhanced liver apoptosis may be a sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b92ad059e99cebc47e7cfb293b9a4f2
https://doi.org/10.1111/j.1530-0277.2001.tb02300.x

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Alcohol-induced sinusoidal endothelial cell dysfunction in the mouse is associated with exacerbated liver apoptosis and can be reversed by caspase inhibition

Autor: Franco Fortunato, Theodore G. Sarphie, Nympha B. D'Souza, Daniell B. Hill, Ion V. Deaciuc, Craig J. McClain

Publikováno v: Hepatology Research. 19:85-97

The purpose of this study was to determine if a correlation exists between alcohol-induced liver sinusoidal endothelial cell (SEC) dysfunction and alcohol-induced augmented liver apoptosis in the mouse. Mice were fed an alcohol-containing liquid diet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7827c8f2226f51138b1faf4fb6f315f5
https://doi.org/10.1016/s1386-6346(00)00087-5

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Effect of hypoxia and hypoxia/reoxygenation on proteoglycan metabolism by vascular smooth muscle cells

Autor: Zhuo Tao, Frank W. Smart, Parakat Vijayagopal, Theodore G. Sarphie, D. Luke Glancy, Julio E. Figueroa

Publikováno v: Atherosclerosis. 143:135-144

Hypoxia and hypoxia/reoxygenation are known to affect vascular smooth muscle cell physiology. In this study, we first investigated proteoglycan synthesis by human aortic smooth muscle cells exposed to normoxia, hypoxia, or hypoxia/reoxygenation. We t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694a6d2c5f7b97a37796c49439d9eb3b
https://doi.org/10.1016/s0021-9150(98)00292-5

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Effects of exogenous superoxide anion and nitric oxide on the scavenging function and electron microscopic appearance of the sinusoidal endothelium in the isolated, perfused rat liver

Autor: Craig J. McClain, Ion V. Deaciuc, Theodore G. Sarphie, Nympha B. D'Souza, Daniell B. Hill, Jack Schmidt

Publikováno v: Journal of Hepatology. 30:213-221

Background/Aims: Functional and morphological alterations of the hepatic sinusoidal endothelial cell occur in several models of experimental liver injury and in clinical settings. The causes of these alterations are multiple. The aim of this study wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d706d59fe0ed26e6a20e6aa6a47e88bc
https://doi.org/10.1016/s0168-8278(99)80064-6

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Dose- and Time-Dependent Effects of Ethanol on Functional and Structural Aspects of the Liver Sinusoid in the Mouse

Autor: Nympha B. D'Souza, D Hill, D. H. Van Thiel, Craig J. McClain, Ion V. Deaciuc, G Sarphie

Publikováno v: Alcoholism: Clinical and Experimental Research. 21:1128-1136

Increasing evidence implicates injury of hepatic sinusoidal endothelial cells as an important component in the development of several forms of liver injury. The purpose of this study was to test the hypothesis that alcohol [ethanol (EtOH)]-induced pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01c531cdb928f95bb7cb449d8e85cf9d
https://doi.org/10.1111/j.1530-0277.1997.tb04263.x

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Effects of NO synthase inhibitors, arginine-deficient diet, and amiloride in pregnant rats

Autor: Jack R. Lancaster, Daniel R. Kapusta, T. G. Sarphie, T. Freeman, Thomas D. Giles, David R. Powers, L. Hua, Xinfang Zhao, Stan S. Greenberg, Jianming Xie

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 273:R1031-R1045

This study tests the hypothesis that nitric oxide synthase (NOS) inhibition is linked to NG-nitro-L-arginine methyl ester (L-NAME)-mediated intrauterine growth retardation (IUGR) and fetal limb reduction deficits (LRD) in pregnant dams. Administratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11451e8e7e116d0092ed4531e279c054
https://doi.org/10.1152/ajpregu.1997.273.3.r1031

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Chronic Alcohol Feeding in Liquid Diet or in Drinking Water Has Similar Effects on Electron Microscopic Appearance of the Hepatic Sinusoid in the Rat

Autor: Nympha B. D'Souza, John J. Spitzer, Theodore G. Sarphie, Ion V. Deaciuc

Publikováno v: Alcoholism: Clinical and Experimental Research. 20:973-979

Electron microscopic appearance of the liver sinusoid was examined in rats fed alcohol chronically in a complete liquid diet or in sucrose-containing drinking water. The animals were kept on liquid diet (+/- alcohol) for 14 weeks or on sucrose-contai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6260f49a580ed48679eda12de4a9fb1
https://doi.org/10.1111/j.1530-0277.1996.tb01933.x

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Metabolism of apoE-free high density lipoproteins in rat hepatoma cells: evidence for a retroendocytic pathway

Autor: John G. DeLamatre, Conrad A. Hornick, T. G. Sarphie, Ronald C. Archibold

Publikováno v: Journal of Lipid Research, Vol 31, Iss 2, Pp 191-202 (1990)

The cellular metabolism of apoE-free HDL (HDL) was studied in rat hepatoma cells (FU5AH). Cells incubated with HDL showed a dose-dependent decreased incorporation of [14C]acetate into cell sterol, indicating a net cholesterol delivery to the cells. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f49d8eb8cc247de7e551e38b0aacc9c
https://doi.org/10.1016/s0022-2275(20)43205-5

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Inhibition of caspases in vivo protects the rat liver against alcohol-induced sensitization to bacterial lipopolysaccharide

Autor: I V, Deaciuc, N B, D'Souza, W J, de Villiers, R, Burikhanov, T G, Sarphie, D B, Hill, C J, McClain

Publikováno v: Alcoholism, clinical and experimental research. 25(6)

The mechanisms of liver sensitization by alcohol to Gram-negative bacterial lipopolysaccharide (LPS) remain elusive. The purpose of this study was two-fold: (1) to test the hypothesis that alcohol-enhanced liver apoptosis may be a sensitizing mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3160b47fae43c33b5e96ab82f9278c67
https://pubmed.ncbi.nlm.nih.gov/11410731

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