Molecular and Functional Characterization of Human Intestinal Organoids and Monolayers for Modeling Epithelial Barrier

Autor: Scott A Jelinsky, Merel Derksen, Eric Bauman, Carla S Verissimo, Wies T M van Dooremalen, Jamie Lee Roos, Celia Higuera Barón, Celia Caballero-Franco, Bryce G Johnson, Michelle G Rooks, Johanna Pott, Bas Oldenburg, Robert G J Vries, Sylvia F Boj, Marion T Kasaian, Farzin Pourfarzad, Charles V Rosadini

Publikováno v: Inflammatory bowel diseases.

Background Patient-derived organoid (PDO) models offer potential to transform drug discovery for inflammatory bowel disease (IBD) but are limited by inconsistencies with differentiation and functional characterization. We profiled molecular and cellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f32b4dc5502df57f0facfdee5d71ce9
https://pubmed.ncbi.nlm.nih.gov/36356046

QseC inhibition as an antivirulence approach for colitis-associated bacteria

Autor: Carey Ann Gallini, Sydney Lavoie, Curtis Huttenhower, Cammie F. Lesser, Patrick Veiga, Yasunari Asano, Nobuyuki Sudo, Analise Z. Reeves, Monia Michaud, Michelle G. Rooks, Jonathan N. Glickman, Koji Yasuda, Kazufumi Yoshihara, Leslie H Wardwell-Scott, Wendy S. Garrett

Hosts and their microbes have established a sophisticated communication system over many millennia. Within mammalian hosts, this dynamic cross-talk is essential for maintaining intestinal homeostasis. In a genetically susceptible host, dysbiosis of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe4ede4fec00832125068199a89c16c
https://europepmc.org/articles/PMC5224399/

Differential inhibition of plasma versus tissue ACE by utibapril

Autor: YM Pinto, W. H. Van Gilst, Hendrik Buikema, PP van Geel, C. D. J. de Langen, G Rooks, P.A. de Graeff

Publikováno v: Journal of Cardiovascular Pharmacology, 29(5), 684-691
Journal of cardiovascular pharmacology, 29(5), 684-691. Lippincott Williams and Wilkins

Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with a proposed tissue-specific inhibitory profile. This implies that at a certain dose, utibapril should be able to inhibit tissue ACE activity without affecting plasma ACE. Moreover, if

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c6f0873e971ac4f4c5828be89f1212
https://doi.org/10.1097/00005344-199705000-00018

Bacteria, food, and cancer

Autor: Michelle G. Rooks, Wendy S. Garrett

Publikováno v: F1000 Biology Reports

Gut microbes are essential components of the human organism-helping us metabolize food into energy, produce micronutrients, and shape our immune systems. Having a particular pattern of gut microbes is also increasingly being linked to medical conditi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba570cb0e68dd8cffff29e4918d1faf5
https://doi.org/10.3410/b3-12

A primary care preceptorship for first-year medical students coordinated by an Area Health Education Center program: a six-year review

Autor: Larry G. Rooks, Robert T. Watson, J. Harris

Publikováno v: Academic medicine : journal of the Association of American Medical Colleges. 76(5)

In 1991, the University of Florida College of Medicine established a required primary care preceptorship coordinated by the Area Health Education Center (AHEC) Program for all students in the first semester of medical school. Six years' experience wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46f4b5182cf9488e5b40e56e4d4550f
https://pubmed.ncbi.nlm.nih.gov/11346530