Výsledky vyhledávání

Hexose monophosphate shunt activity in erythrocytes related to cell age

Autor: G. E. J. Staal, P. Damen, K. De Haan, R. Ouwerkerk, G. Rijksen

Publikováno v: European Journal of Haematology. 43:441-447

Erythrocytes were separated by age using a combination of density centrifugation and counterflow centrifugation and tested for basal activity of the hexose monophosphate shunt (HMP-shunt) as well as the methylene blue-stimulated maximal capacity by m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2747a6b94169d30d76d332351624ec5
https://doi.org/10.1111/j.1600-0609.1989.tb00333.x

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Standardization of an Enzyme-Linked Immunosorbent Assay for the Determination of Protein Tyrosine Kinase Activity

Autor: M. Salden, G.E.J. Staal, G. Rijksen, B. Schraag, S.S. Adriaansenslot

Publikováno v: Analytical Biochemistry. 211:233-239

A procedure for an enzyme-linked immunosorbent assay for the determination of protein tyrosine kinase (PTK) activity from cytosolic and solubilized membrane fractions from breast cancers, is described. The general PTK substrate poly(GluNa, Tyr) 4:1 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e29b3cf4374bf52eb8e289070c8b6f2
https://doi.org/10.1006/abio.1993.1262

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Distinction of two different classes of small-cell lung cancer cell lines by enzymatically inactive neuron-specific enolase

Autor: T. A. W. Splinter, A. Van De Gaast, C. F. Verkoelen, F. Boomsma, M. Vlastuin, G. Rijksen, T. C. Kok, K. G. Haglid

Publikováno v: British Journal of Cancer

Neuron specific enolase (NSE) is widely used as a neuro-endocrine marker. However the presence of NSE in many non-neuroendocrine tissues has raised questions on the specificity of NSE. We have investigated NSE immunoreactivity (NSA-ag), gamma-enolase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1045b99026923f76cdc02f650918ed
http://europepmc.org/articles/PMC1978033

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31P nuclear magnetic resonance and zero-point titration compared for measuring free magnesium concentration in erythrocytes

Autor: W.B. Geven, Johannes L. Willems, G. RiJksen, C. W. Hilbers, C H von Os, G. M. Vogels-Mentink, Leo A. H. Monnens, J. J. M. Joordens

Publikováno v: Clinical Chemistry. 37:2076-2080

Intracellular ionized magnesium concentrations ([Mg2+]i) were measured in erythrocytes by 31P nuclear magnetic resonance (NMR) and zero-point titration in 14 controls and seven patients with renal magnesium loss. The mean intracellular ionized magnes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d6050d50fe46e335ce0a1a4a0f46735
https://doi.org/10.1093/clinchem/37.12.2076

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[From gene to disease; hereditary non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency]

Autor: K M K, de Vooght, R, van Wijk, H K, Nieuwenhuis, J K, Ploos van Amstel, G, Rijksen, W W, van Solinge

Publikováno v: Nederlands tijdschrift voor geneeskunde. 146(39)

Pyruvate kinase (PK) deficiency is a common cause of hereditary non-spherocytic haemolytic anaemia. It is an autosomal recessive disorder caused by mutations in the gene coding for erythrocyte and liver-type pyruvate kinase (PKLR). So far, more than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1db03cae4f010d480a2ae64e869ab88
https://pubmed.ncbi.nlm.nih.gov/12382367

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Growth-inhibitory effects of 5,10-dideazatetrahydrofolic acid on variant murine L1210 and human CCRF-CEM leukemia cells with different membrane-transport characteristics for (anti)folate compounds

Autor: Ietje Kathmann, G R Westerhof, G Rijksen, Jan H. Schornagel, Gerrit Jansen

Publikováno v: Cancer Chemotherapy and Pharmacology, 28(2), 115-7. Springer Verlag
Jansen, G, Westerhof, G R, Kathmann, I, Rijksen, G & Schornagel, J H 1991, ' Growth-inhibitory effects of 5,10-dideazatetrahydrofolic acid on variant murine L1210 and human CCRF-CEM leukemia cells with different membrane-transport characteristics for (anti)folate compounds ', Cancer Chemotherapy and Pharmacology, vol. 28, no. 2, pp. 115-7 .

5,10-Dideazatetrahydrofolic acid (DDATHF) is a potent inhibitor of glycinamide ribonucleotide transformylase, one of the folate-dependent key enzymes in de novo purine biosynthesis. The present report demonstrates that multiple membrane-transport rou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0869b74becf9f7a06a22fc5083af3a20
https://doi.org/10.1007/bf00689699

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CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes

Autor: G J, Boonen, A M, van Dijk, L F, Verdonck, R A, van Lier, G, Rijksen, R H, Medema

Publikováno v: European journal of immunology. 29(3)

CD28 is the primary T cell costimulatory receptor, and upon ligation with its ligands, it enhances T cell proliferation and IL-2 synthesis. In this study we examined the role of CD28 in the initial proliferative response and cell cycle entry of T lym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::441e937e98b97e220cf3c54317730d25
https://pubmed.ncbi.nlm.nih.gov/10092081

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Overexpression of c-Src in areas of hyperproliferation in head and neck cancer, premalignant lesions and benign mucosal disorders

Autor: M. G. C. T. Oijen, F. W. ten Broek, Pieter J. Slootweg, G. Rijksen

Publikováno v: Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 27(4)

To examine which proteins are responsible for the elevated protein tyrosine kinase (PTK) activity in human head and neck squamous cell carcinoma (HNSCC) and adjacent histologically normal epithelium, paraffin embedded sections of these tissues were s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4501d4c44350119517780d7f62e38f1
https://pubmed.ncbi.nlm.nih.gov/9563568

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Grb2 overexpression in nuclei and cytoplasm of human breast cells: a histochemical and biochemical study of normal and neoplastic mammary tissue specimens

Autor: B S, Verbeek, S S, Adriaansen-Slot, G, Rijksen, T M, Vroom

Publikováno v: The Journal of pathology. 183(2)

In 20-30 per cent of human breast cancers, the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and c-erbB2 are overexpressed. This overexpression leads to increased mitogenic signalling and is correlated with poor prognosis. Overexp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b197b32e4052d044aa00eb4215eea18
https://pubmed.ncbi.nlm.nih.gov/9390033

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c-Src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysis

Autor: B S, Verbeek, T M, Vroom, S S, Adriaansen-Slot, A E, Ottenhoff-Kalff, J G, Geertzema, A, Hennipman, G, Rijksen

Publikováno v: The Journal of pathology. 180(4)

In human breast cancer, c-Src activity is elevated compared to normal breast tissue. It is not yet known whether this increase in c-Src activity is accompanied by an increase in c-Src protein expression. In this study, c-Src activity and protein expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::382b54e6700a8ddf9d67fba0bef601f3
https://pubmed.ncbi.nlm.nih.gov/9014858

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