Zobrazeno 1 - 10
of 718
pro vyhledávání: '"G, Regehr"'
Publikováno v:
eLife, Vol 13 (2024)
Purkinje cell (PC) synapses onto cerebellar nuclei (CbN) neurons allow signals from the cerebellar cortex to influence the rest of the brain. PCs are inhibitory neurons that spontaneously fire at high rates, and many PC inputs are thought to converge
Externí odkaz:
https://doaj.org/article/acf28932fe734e6abab14a3836b58c47
Autor:
Joon-Hyuk Lee, Mehak M. Khan, Amanda P. Stark, Soobin Seo, Aliya Norton, Zhiyi Yao, Christopher H. Chen, Wade G. Regehr
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112429- (2023)
Summary: Within the cerebellar cortex, mossy fibers (MFs) excite granule cells (GCs) that excite Purkinje cells (PCs), which provide outputs to the deep cerebellar nuclei (DCNs). It is well established that PC disruption produces motor deficits such
Externí odkaz:
https://doaj.org/article/cf6ce60d919840059e711ae00151bf5f
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The authors show that graded molecular heterogeneity in metabotropic pathways underlies a continuum of temporal responses in cerebellar unipolar brush cells (UBCs). This allows the UBC population to serve as a cell-autonomous basis for temporal integ
Externí odkaz:
https://doaj.org/article/98d53dab60cf463d91e36550272c31ee
Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109719- (2021)
Summary: Synaptotagmin 7 (Syt7) is a high-affinity calcium sensor that is implicated in multiple aspects of synaptic transmission. Here, we study the influence of Syt7 on the climbing fiber (CF) to Purkinje cell (PC) synapse. We find that small facil
Externí odkaz:
https://doaj.org/article/bc1427e612d440929e0dac1bb0811cea
Publikováno v:
eLife, Vol 10 (2021)
Circuitry of the cerebellar cortex is regionally and functionally specialized. Unipolar brush cells (UBCs), and Purkinje cell (PC) synapses made by axon collaterals in the granular layer, are both enriched in areas that control balance and eye moveme
Externí odkaz:
https://doaj.org/article/7c45a5b911d34b3893a5381446a18949
Autor:
Josef Turecek, Wade G Regehr
Publikováno v:
eLife, Vol 9 (2020)
The inferior olive (IO) is composed of electrically-coupled neurons that make climbing fiber synapses onto Purkinje cells. Neurons in different IO subnuclei are inhibited by synapses with wide ranging release kinetics. Inhibition can be exclusively s
Externí odkaz:
https://doaj.org/article/7d6b3d8955694e658926da7c7f1e4b63
Autor:
Stephanie Rudolph, Chong Guo, Stan L. Pashkovski, Tomas Osorno, Winthrop F. Gillis, Jeremy M. Krauss, Hajnalka Nyitrai, Isabella Flaquer, Mahmoud El-Rifai, Sandeep Robert Datta, Wade G. Regehr
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108338- (2020)
Summary: Granule cells (GCs) of the cerebellar input layer express high-affinity δ GABAA subunit-containing GABAA receptors (δGABAARs) that respond to ambient GABA levels and context-dependent neuromodulators like steroids. We find that GC-specific
Externí odkaz:
https://doaj.org/article/682044dfb8cb4261a2b5d5bdd530af5e
Autor:
Tri M. Nguyen, Logan A. Thomas, Jeff L. Rhoades, Ilaria Ricchi, Xintong Cindy Yuan, Arlo Sheridan, David G. C. Hildebrand, Jan Funke, Wade G. Regehr, Wei-Chung Allen Lee
Publikováno v:
Nature
The cerebellum is thought to help detect and correct errors between intended and executed commands(1,2) and is critical for social behaviours, cognition and emotion 3 Computations for motor control must be performed quicklyto correct errors in real t
Autor:
Mehak M Khan, Wade G Regehr
Publikováno v:
eLife, Vol 9 (2020)
Doc2a and Doc2b are high-affinity calcium-binding proteins that interact with SNARE proteins and phospholipids. Experiments performed on cultured cells indicated that Doc2 proteins promote spontaneous vesicle fusion and asynchronous neurotransmitter
Externí odkaz:
https://doaj.org/article/38acf0282f344e08b06702aa9197aad4
Autor:
Skyler L Jackman, Christopher H Chen, Heather L Offermann, Iain R Drew, Bailey M Harrison, Anna M Bowman, Katelyn M Flick, Isabella Flaquer, Wade G Regehr
Publikováno v:
eLife, Vol 9 (2020)
Although the cerebellum is traditionally associated with balance and motor function, it also plays wider roles in affective and cognitive behaviors. Evidence suggests that the cerebellar vermis may regulate aggressive behavior, though the cerebellar
Externí odkaz:
https://doaj.org/article/8f2ce728929d46918f77b3d691d75aaa