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Akademický článek
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Autor:
David G. Orloff, Harold E. Bays, Svein Olaf Hustvedt, John J.P. Kastelein, David A. Fraser, Rong Zhou, Runar Vige, Jonas Hallén
Publikováno v:
Cardiology, 135(1), 3-12. S. Karger AG
Objectives: To evaluate the efficacy and safety of icosabutate, an oral, once-daily, first-in-class medication, in reducing non-high-density lipoprotein cholesterol (non-HDL-C) in patients with persistent hypertriglyceridemia despite statin therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8973fbc7d5f3a2ecfa2d39076985632b
https://doi.org/10.1159/000445047
https://doi.org/10.1159/000445047
Autor:
David G. Orloff, John J.P. Kastelein, Harold E. Bays, David A. Fraser, Svein Olaf Hustvedt, Rong Zhou, Jonas Hallén, Runar Vige
Publikováno v:
Journal of clinical lipidology, 10(1). Elsevier BV
Icosabutate is a structurally enhanced omega-3 fatty acid molecule developed with the aim of achieving improved triglyceride (TG)-lowering efficacy, increased potency, and preserved safety compared with conventional prescription omega-3 fatty acid. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab033ab6692feaaaec80b0f1a27d503
https://doi.org/10.1016/j.jacl.2015.10.012
https://doi.org/10.1016/j.jacl.2015.10.012
Publikováno v:
Journal of Toxicology and Environmental Health, Part B. 12:509-524
Arsenic (As) is a widely occurring environmental contaminant. To assess human exposures to As, public health officials and researchers often conduct biomonitoring. Samples of urine, hair, nails, or blood are collected from potentially exposed people
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad20b8657f333cf43cca2711df0374c6
https://doi.org/10.1080/10937400903358934
https://doi.org/10.1080/10937400903358934
Autor:
David G. Orloff
Publikováno v:
The American Journal of Cardiology. 100:S10-S14
The development of high-density lipoprotein (HDL) therapies has experienced a recent setback with the notable termination of clinical development of torcetrapib, a cholesteryl ester transfer protein inhibitor. Potentially because of off-target action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf93815c0da11b6e25dac61e72d18353
https://doi.org/10.1016/j.amjcard.2007.08.007
https://doi.org/10.1016/j.amjcard.2007.08.007
Autor:
Eli M. Roth, Kevin C. Maki, Douglas Kling, Judith Johnson, Michael H. Davidson, Stephen J. Nicholls, David G. Orloff, Richard L. Dunbar, Danielle Curcio
Publikováno v:
Lipids in Health and Disease
This study examined the effects of a mixture of highly bioavailable omega-3 carboxylic acids (OM3-CA) on nuclear magnetic resonance spectroscopy–assessed lipoprotein particle concentrations and sizes and other cardiovascular risk markers in statin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a2c5b96abe208a2c152999e71634ec
https://pubmed.ncbi.nlm.nih.gov/26328624
https://pubmed.ncbi.nlm.nih.gov/26328624
Publikováno v:
Atmospheric Environment. 40:3022-3029
To extract gold from low-grade ores, a solution of sodium cyanide is trickled over pads of crushed ore. During this operation, small quantities of hydrogen cyanide gas may escape to the ambient air. To assess these emissions, we collected air samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54a0f27b2b2b8a626c67fdf0c3e7cb77
https://doi.org/10.1016/j.atmosenv.2005.09.089
https://doi.org/10.1016/j.atmosenv.2005.09.089
Autor:
David G. Orloff
Publikováno v:
The American Journal of Cardiology. 96:28-33
The use of combination drug therapy for cardiovascular (CV) disease risk reduction is the established approach to multiple risk factor reduction. The spectrum of rational combination products in CV disease prevention and treatment alone is extremely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8f913e018fc174604cb827d6eff12d
https://doi.org/10.1016/j.amjcard.2005.08.005
https://doi.org/10.1016/j.amjcard.2005.08.005
Publikováno v:
The American Journal of Cardiology. 93:49-52
h s t l t l f e s the incidence of diabetes mellitus, dyslipidemia, and the metabolic syndrome (MS) continues o increase worldwide, the pharmaceutical industry is aced with numerous challenges when developing and arketing new agents to control these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5a615a2dc210d5d3607074b832246f
https://doi.org/10.1016/j.amjcard.2004.02.007
https://doi.org/10.1016/j.amjcard.2004.02.007