Zobrazeno 1 - 10
of 340
pro vyhledávání: '"G, Olivero"'
Autor:
Lori S. Friedman, Anwesha Dey, Donald S. Kirkpatrick, Steven T. Staben, Shiva Malek, Alan G. Olivero, Timothy P. Heffron, Laurent Salphati, Gail D. Lewis Phillips, Emile G. Plise, Jonathan Cheong, Jeffrey J. Wallin, Jane Guan, Nicholas Endres, Stephen Schmidt, Eric Stawiski, William F. Forrest, Lilian Phu, Rebecca Hong, Michelle A. Nannini, Deepak Sampath, Mark Merchant, Jason Oeh, Marc Hafner, Emily J. Hanan, Kyle A. Edgar, Kyung W. Song
RTK activity plays a key role in regulating p110a degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3f61f91c6eba4539d57e9ffe438944
https://doi.org/10.1158/2159-8290.22540279
https://doi.org/10.1158/2159-8290.22540279
Autor:
Lori S. Friedman, Anwesha Dey, Donald S. Kirkpatrick, Steven T. Staben, Shiva Malek, Alan G. Olivero, Timothy P. Heffron, Laurent Salphati, Gail D. Lewis Phillips, Emile G. Plise, Jonathan Cheong, Jeffrey J. Wallin, Jane Guan, Nicholas Endres, Stephen Schmidt, Eric Stawiski, William F. Forrest, Lilian Phu, Rebecca Hong, Michelle A. Nannini, Deepak Sampath, Mark Merchant, Jason Oeh, Marc Hafner, Emily J. Hanan, Kyle A. Edgar, Kyung W. Song
PIK3CA is one of the most frequently mutated oncogenes; the p110a protein it encodes plays a central role in tumor cell proliferation. Small-molecule inhibitors targeting the PI3K p110a catalytic subunit have entered clinical trials, with early-phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd67c192262a4b6f3e1d058d9266830
https://doi.org/10.1158/2159-8290.c.6549343
https://doi.org/10.1158/2159-8290.c.6549343
Autor:
Lori S. Friedman, Marcia Belvin, Deepak Sampath, Mark R. Lackner, Leanne Ross, Robert Kassees, Letitia Lensun, Sonal Patel, Jill M. Spoerke, Carol O'Brien, Daniel P. Sutherlin, Alan G. Olivero, Laurent Salphati, Jodie Pang, Jim Nonomiya, Cristina Lewis, John D. Lesnick, Leslie Lee, Wei Wei Prior, Megan Berry, Jane Guan, Kyle A. Edgar, Jeffrey J. Wallin
PDF file - 894K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136e199abb6bc063918f64da058aa806
https://doi.org/10.1158/1535-7163.22496520
https://doi.org/10.1158/1535-7163.22496520
Autor:
Lori S. Friedman, Marcia Belvin, Deepak Sampath, Mark R. Lackner, Leanne Ross, Robert Kassees, Letitia Lensun, Sonal Patel, Jill M. Spoerke, Carol O'Brien, Daniel P. Sutherlin, Alan G. Olivero, Laurent Salphati, Jodie Pang, Jim Nonomiya, Cristina Lewis, John D. Lesnick, Leslie Lee, Wei Wei Prior, Megan Berry, Jane Guan, Kyle A. Edgar, Jeffrey J. Wallin
Alterations of the phosphoinositide-3 kinase (PI3K)/Akt signaling pathway occur broadly in cancer via multiple mechanisms including mutation of the PIK3CA gene, loss or mutation of phosphatase and tensin homolog (PTEN), and deregulation of mammalian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344448ff3a06fe2f5d7081d2a898c2c2
https://doi.org/10.1158/1535-7163.c.6535305
https://doi.org/10.1158/1535-7163.c.6535305
Autor:
Patrick Y. Wen, Timothy F. Cloughesy, Elizabeth Gerstner, Jordi Rodon, Lars U. Mueller, Alan G. Olivero, James S. Garner, Jeremy Simpson, Ararat Chakhoyan, David A. Nathanson, Catalina Raymond, Jingwen Yao, Benjamin M. Ellingson
Correlation between multi-parametric MR-PET imaging changes before and after GDC-0084. A) Pearson's correlation coefficient (R) and B) resulting p-values describing the association between all imaging measurements. No significant correlations (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f082869191f07f788211ec509bdb19
https://doi.org/10.1158/1078-0432.22475775
https://doi.org/10.1158/1078-0432.22475775
Autor:
Heidi S. Phillips, Alan G. Olivero, Stephen E. Gould, Xiaolin Zhang, Jeffrey J. Wallin, Jann N. Sarkaria, Hani Bou Reslan, Jenny L. Pokorny, Emile G. Plise, Jodie Pang, Leslie B. Lee, Shari Lau, Hartmut Koeppen, Samir Kharbanda, Joan Greve, Kyle A. Edgar, Jonathan Cheong, Richard A. Carano, Kai Barck, Merry Nishimura, Bruno Alicke, Timothy P. Heffron, Laurent Salphati
PDF file - 55K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc838fa47a9d23267b37a858ed4d3f8
https://doi.org/10.1158/1078-0432.22447710
https://doi.org/10.1158/1078-0432.22447710
Autor:
Heidi S. Phillips, Alan G. Olivero, Stephen E. Gould, Xiaolin Zhang, Jeffrey J. Wallin, Jann N. Sarkaria, Hani Bou Reslan, Jenny L. Pokorny, Emile G. Plise, Jodie Pang, Leslie B. Lee, Shari Lau, Hartmut Koeppen, Samir Kharbanda, Joan Greve, Kyle A. Edgar, Jonathan Cheong, Richard A. Carano, Kai Barck, Merry Nishimura, Bruno Alicke, Timothy P. Heffron, Laurent Salphati
PDF file - 77K, Cell viability following treatment with GNE-317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b14e8b2c62065f86e47c21ee5d4697a
https://doi.org/10.1158/1078-0432.22447713.v1
https://doi.org/10.1158/1078-0432.22447713.v1
Autor:
Patrick Y. Wen, Timothy F. Cloughesy, Elizabeth Gerstner, Jordi Rodon, Lars U. Mueller, Alan G. Olivero, James S. Garner, Jeremy Simpson, Ararat Chakhoyan, David A. Nathanson, Catalina Raymond, Jingwen Yao, Benjamin M. Ellingson
Examples of metabolic responders to GDC-0084 as indicated by a decrease in 18F-FDG PET uptake. A-B) Examples of a clear reduction in focal 18F-FDG uptake within the tumor. C-E) Example of more subtle reduction in 18F-FDG uptake after GDC-0084. C and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c83062aef032a41147d9e199a454185
https://doi.org/10.1158/1078-0432.22475778
https://doi.org/10.1158/1078-0432.22475778
Autor:
Heidi S. Phillips, Alan G. Olivero, Stephen E. Gould, Xiaolin Zhang, Jeffrey J. Wallin, Jann N. Sarkaria, Hani Bou Reslan, Jenny L. Pokorny, Emile G. Plise, Jodie Pang, Leslie B. Lee, Shari Lau, Hartmut Koeppen, Samir Kharbanda, Joan Greve, Kyle A. Edgar, Jonathan Cheong, Richard A. Carano, Kai Barck, Merry Nishimura, Bruno Alicke, Timothy P. Heffron, Laurent Salphati
PDF file - 60K, Plasma Concentrations, Brain Concentrations and Brain-to-Plasma Ratio Measured at the End of Study (42 days) 2 hours Following the Last Daily PO Administration of GNE-317 (40 mg/kg), GDC-0941 (250 mg/kg) or GDC-0980 (10 mg/kg) to GS2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1649707918904ad8cbd83771a80366bc
https://doi.org/10.1158/1078-0432.22447701
https://doi.org/10.1158/1078-0432.22447701
Autor:
Patrick Y. Wen, Timothy F. Cloughesy, Elizabeth Gerstner, Jordi Rodon, Lars U. Mueller, Alan G. Olivero, James S. Garner, Jeremy Simpson, Ararat Chakhoyan, David A. Nathanson, Catalina Raymond, Jingwen Yao, Benjamin M. Ellingson
Post-treatment multi-parametric MR-PET imaging measurements and responses for each oral dose of GDC-0084. Post-treatment measurements of A) contrast enhancing tumor volume, B) median 18F-FDG uptake relative to white matter, C) median ADC, D) median F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df2d13672ba7d84f7701d52ec760479
https://doi.org/10.1158/1078-0432.22475772
https://doi.org/10.1158/1078-0432.22475772