Zobrazeno 1 - 10
of 405
pro vyhledávání: '"G, Oertel"'
Publikováno v:
IBRO Reports, Vol 7, Iss , Pp 117-128 (2019)
Background: Cannabis proofed to be effective in pain relief, but one major side effect is its influence on memory in humans. Therefore, the role of memory on central processing of nociceptive information was investigated in healthy volunteers. Method
Externí odkaz:
https://doaj.org/article/1135d487fb454d9da14d6806039852f8
Autor:
Jörn Lötsch, Dario Kringel, Gerd Geisslinger, Bruno G. Oertel, Eduard Resch, Sebastian Malkusch
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4367 (2020)
Genetic association studies have shown their usefulness in assessing the role of ion channels in human thermal pain perception. We used machine learning to construct a complex phenotype from pain thresholds to thermal stimuli and associate it with th
Externí odkaz:
https://doaj.org/article/f52539c8076449028c62699e09431392
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125822 (2015)
It is assumed that different pain phenotypes are based on varying molecular pathomechanisms. Distinct ion channels seem to be associated with the perception of cold pain, in particular TRPM8 and TRPA1 have been highlighted previously. The present stu
Externí odkaz:
https://doaj.org/article/93e62f7dac2440e883087951a4795936
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132069 (2015)
The perception of pain is susceptible to modulation by psychological and contextual factors. It has been shown that subjects judge noxious stimuli as more painful in a respective suggestive context, which disappears when the modifying context is reso
Externí odkaz:
https://doaj.org/article/7c1b21684b07441587d2f0f24cf68377
Autor:
Miriam Wolters, Martin Zunftmeister, T. Rossmanith, Gerd Geisslinger, Carmen Walter, Bruno G. Oertel, Jörn Lötsch, Nerea Ferreirós, Sebastian Zinn
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 126:318-331
Persistent and, in particular, neuropathic pain is a major healthcare problem with still insufficient pharmacological treatment options. This triggered research activities aimed at finding analgesics with a novel mechanism of action. Results of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01809f01ab6f3543e8b38543b00a03ac
https://doi.org/10.1111/bcpt.13337
https://doi.org/10.1111/bcpt.13337
Autor:
Michael Schütz, Bruno G Oertel, Dirk Heimann, Alexandra Doehring, Carmen Walter, Violeta Dimova, Gerd Geisslinger, Jörn Lötsch
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95592 (2014)
BACKGROUND: TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics with increased sensitivity to thermal pain stimuli, we therefore hypothesized that this as
Externí odkaz:
https://doaj.org/article/320124138a0a4d3d988ba62a801a7645
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68654 (2013)
BACKGROUND AND AIMS: Mutations reducing the function of Nav1.7 sodium channels entail diminished pain perception and olfactory acuity, suggesting a link between nociception and olfaction at ion channel level. We hypothesized that if such link exists,
Externí odkaz:
https://doaj.org/article/2d3aa12fb2dd468fa1e77266589662b3
Autor:
Dario Kringel, Bruno G. Oertel, Eduard Resch, Sebastian Malkusch, Jörn Lötsch, Gerd Geisslinger
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 4367, p 4367 (2020)
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4367, p 4367 (2020)
Volume 21
Issue 12
Genetic association studies have shown their usefulness in assessing the role of ion channels in human thermal pain perception. We used machine learning to construct a complex phenotype from pain thresholds to thermal stimuli and associate it with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a8557c7d5129f8931ca4dd33319c38
https://pubmed.ncbi.nlm.nih.gov/32575443
https://pubmed.ncbi.nlm.nih.gov/32575443
Publikováno v:
European Journal of Clinical Pharmacology
Purpose The antifungal drugs ketoconazole and itraconazole reduce serum concentrations of 4β-hydroxycholesterol, which is a validated marker for hepatic cytochrome P450 (CYP) 3A4 activity. We tested the effect of another antifungal triazole agent, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ba75064eab75b21567beb453f047e6
https://pubmed.ncbi.nlm.nih.gov/33201347
https://pubmed.ncbi.nlm.nih.gov/33201347
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34798 (2012)
Increasing evidence about the central nervous representation of pain in the brain suggests that the operculo-insular cortex is a crucial part of the pain matrix. The pain-specificity of a brain region may be tested by administering nociceptive stimul
Externí odkaz:
https://doaj.org/article/6413e6fd858a4995b6b8de3af3225da3