Zobrazeno 1 - 10
of 467
pro vyhledávání: '"G, Moldenhauer"'
Autor:
Natalie Erbe-Hofmann, Sascha Keller, Aurelia Noske, Alexei V. Salnikov, Niko P. Bretz, Thomas Schlange, Glen Kristiansen, G. Moldenhauer, Peter Altevogt
Publikováno v:
Clinical & Experimental Metastasis. 29:27-38
CD24 is a glycosyl-phosphatidylinositol-anchored protein with mucin-type structure that resides exclusively in membrane microdomains. CD24 is often highly expressed in carcinomas and correlates with poor prognosis. Experimentally, the over-expression
Autor:
Linda M. Liau, Lauren T. McGillicuddy, G. Moldenhauer, Jody A. Fromm, Charles L. Sawyers, Sara Kubek, Bryan W. Johnson, Annabel H. A. Parret, Thomas De Raedt, Karen Cichowski, Sybil M. Genther Williams, Ludwine Messiaen, Paul S. Mischel, Rameen Beroukhim, Cameron Brennan, Klaus Scheffzek, Timothy F. Cloughesy, Anat Stemmer-Rachamimov, Jeanette Seiler, Pablo E. Hollstein, Ingo K. Mellinghoff, Phioanh L. Nghiemphu
Publikováno v:
Cancer Cell. 16:44-54
SummaryLoss-of-function mutations in the NF1 tumor suppressor result in deregulated Ras signaling and drive tumorigenesis in the familial cancer syndrome neurofibromatosis type I. However, the extent to which NF1 inactivation promotes sporadic tumori
Autor:
Günter J. Hämmerling, Bernd Arnold, Delia J. Nelson, G. Moldenhauer, Ruth Ganss, Juliana Hamzah
Publikováno v:
Journal of Clinical Investigation. 118:1691-1699
Current anticancer therapy is a delicate balance between elimination of malignant cells and harmful side effects for the host. In this study, we used a tumor-homing peptide to engineer anti-CD40 agonist antibodies and recombinant IL-2 such that they
Autor:
Marco Pfeifer, Svenja Riedle, M Arlt, G. Moldenhauer, Michael P. Sanderson, Peter Altevogt, Mina Fogel, Yasmin Issa, Daniela Gast, Achim Krüger, Philipp Beckhove
Publikováno v:
Oncogene. 27:1281-1289
L1 cell adhesion molecule (L1-CAM) is a transmembrane cell adhesion molecule involved in cell migration and axon guidance in the developing nervous system. L1 is also overexpressed in ovarian and endometrial carcinomas and is associated with a bad pr
Autor:
Alexandra Demory, Pat Metharom, Bernd Arnold, G. Moldenhauer, Martin Falkowski, Selma Ugurel, G. Geginat, Sergij Goerdt, Hjalmar Kurzen, Ruth Ganss, Kai Schledzewski, B. Falkowska-Hansen, Julia Kzhyshkowska
Publikováno v:
The Journal of Pathology. 209:67-77
Lymphangiogenesis is a novel prognostic parameter for several cancers that is preferentially quantified by immunohistochemistry of the lymphatic endothelium-specific hyaluronan receptor LYVE-1. Recently, the specificity of LYVE-1 was challenged by se
Publikováno v:
Immunology. 96:473-484
Transport of major histocompatibility complex (MHC) class II molecules to the endocytic route is directed by the associated invariant chain (Ii). In the endocytic pathway, Ii is proteolytically cleaved and, upon removal of residual Ii fragments, clas
Publikováno v:
Blood. 92:4750-4757
Bispecific antibodies (CD3x19) against the CD3ɛ-chain of the T-cell–receptor/CD3 complex and the CD19 antigen on B cells can target polyclonal, nontumor-specific T cells to B lymphoma cells. This induces T-cell activation, and generation of cytoto
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Publikováno v:
The Journal of Immunology. 147:2643-2651
In previous investigations, it had been shown that class II and associated invariant polypeptides are sorted to an endocytic route where transport is delayed. Invariant chain (Ii) is degraded in a post-Golgi compartment, presumably an endosomal vesic
Autor:
G. Moldenhauer, E. M. Knapp, B. Wängler, Carmen Wängler, R. Saffrich, M. Schnölzer, Walter Mier, Uwe Haberkorn, Michael Eisenhut, Barbro Beijer
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 14(27)
Fluorescent probes are of increasing interest in medicinal and biological applications for the elucidation of the structures and functions of healthy as well as tumour cells. The quality of these investigations is determined by the intensity of the f