Zobrazeno 1 - 10
of 245
pro vyhledávání: '"G, Mastroberardino"'
Autor:
Sander Barnhoorn, Chiara Milanese, Tracy Li, Lieke Dons, Mehrnaz Ghazvini, Martina Sette, Stefania Farina, Daisy Sproviero, Cesar Payan-Gomez, Pier G. Mastroberardino
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-11 (2024)
Abstract The etiopathology of Parkinson’s disease has been associated with mitochondrial defects at genetic, laboratory, epidemiological, and clinical levels. These converging lines of evidence suggest that mitochondrial defects are systemic and ca
Externí odkaz:
https://doaj.org/article/62672389eaaa4e0ba7de59e89c029fb3
Autor:
María B. Birkisdóttir, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling, Ákos Gyenis, Pier G. Mastroberardino, Dick Jaarsma, Harry van Steeg, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Externí odkaz:
https://doaj.org/article/44a09dce31cb497bae23d58181211464
Autor:
María B. Birkisdóttir, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling, Ákos Gyenis, Pier G. Mastroberardino, Dick Jaarsma, Harry van Steeg, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Despite efficient repair, DNA damage inevitably accumulates with time affecting proper cell function and viability, thereby driving systemic aging. Interventions that either prevent DNA damage or enhance DNA repair are thus likely to extend health- a
Externí odkaz:
https://doaj.org/article/8c65fef761fc4154867530db3ca88371
Autor:
Chiara Milanese, Cíntia R. Bombardieri, Sara Sepe, Sander Barnhoorn, César Payán-Goméz, Donatella Caruso, Matteo Audano, Silvia Pedretti, Wilbert P. Vermeij, Renata M. C. Brandt, Akos Gyenis, Mirjam M. Wamelink, Annelieke S. de Wit, Roel C. Janssens, René Leen, André B. P. van Kuilenburg, Nico Mitro, Jan H. J. Hoeijmakers, Pier G. Mastroberardino
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
ERCC1 is involved in a number of DNA repair pathways including nucleotide excision repair. Here the authors showed that reduced transcription in Ercc1-deficient mouse livers and cells increases ATP levels, suppressing glycolysis and rerouting glucose
Externí odkaz:
https://doaj.org/article/0cc0fcac27b44c6fbf79164cbd22e050
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 3 (2020)
Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and redu
Externí odkaz:
https://doaj.org/article/38ee3993d2e94ce08d35389aa635eb69
Autor:
Sara Sepe, Chiara Milanese, Sylvia Gabriels, Kasper W.J. Derks, Cesar Payan-Gomez, Wilfred F.J. van IJcken, Yvonne M.A. Rijksen, Alex L. Nigg, Sandra Moreno, Silvia Cerri, Fabio Blandini, Jan H.J. Hoeijmakers, Pier G. Mastroberardino
Publikováno v:
Cell Reports, Vol 15, Iss 9, Pp 1866-1875 (2016)
The underlying relation between Parkinson’s disease (PD) etiopathology and its major risk factor, aging, is largely unknown. In light of the causative link between genome stability and aging, we investigate a possible nexus between DNA damage accum
Externí odkaz:
https://doaj.org/article/7126e1c82c7a4a0aa0b46f30f13acd3f
Autor:
Matthew J. Birket, Marcelo C. Ribeiro, Georgios Kosmidis, Dorien Ward, Ana Rita Leitoguinho, Vera van de Pol, Cheryl Dambrot, Harsha D. Devalla, Richard P. Davis, Pier G. Mastroberardino, Douwe E. Atsma, Robert Passier, Christine L. Mummery
Publikováno v:
Cell Reports, Vol 13, Iss 4, Pp 733-745 (2015)
Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is essential for their effective application in models of cardiac toxicity and disease. Here, we aimed to identify factors that would promote an adequate le
Externí odkaz:
https://doaj.org/article/43333fc490814a07a17c18b2123d6b0b
Autor:
A. Prodan, H. Davies, H. Eneqvist, G. Mastroberardino, H. Wijayathunga, K. Wardlaw, R.G.M. Morris
Publikováno v:
Neurobiology of learning and memory. 195
This study outlines two novel protocols for examining context specific recall in animals prior to embarking on neurobiological studies. The approach is distinct from and contrasts with studies investigating associative familiarity that depend upon pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f974e818feb38c14879df79aae89eb72
https://pubmed.ncbi.nlm.nih.gov/36174888
https://pubmed.ncbi.nlm.nih.gov/36174888
Autor:
Laurie H. Sanders, Jennifer McCoy, Xiaoping Hu, Pier G. Mastroberardino, Bryan C. Dickinson, Christopher J. Chang, Charleen T. Chu, Bennett Van Houten, J.T. Greenamyre
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 214-223 (2014)
DNA damage can cause (and result from) oxidative stress and mitochondrial impairment, both of which are implicated in the pathogenesis of Parkinson's disease (PD). We therefore examined the role of mitochondrial DNA (mtDNA) damage in human postmortem
Externí odkaz:
https://doaj.org/article/a3e0fb76bd764bb882e1a79cace17569
Autor:
Soile Tapio, Pier G. Mastroberardino, Christos Karapiperis, Lefteris Angelis, Zacharias G. Scouras, Michael J. Atkinson, Christos A. Ouzounis, Anastasia Chasapi
Publikováno v:
Big Data, 9(1), 63-71. Mary Ann Liebert Inc.
As high-throughput approaches in biological and biomedical research are transforming the life sciences into information-driven disciplines, modern analytics platforms for big data have started to address the needs for efficient and systematic data an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5612b466da3268c5f7ca4ebb77fc8807
http://www.scopus.com/inward/record.url?scp=85099281262&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85099281262&partnerID=8YFLogxK