Zobrazeno 1 - 10
of 120
pro vyhledávání: '"G, Mahieu"'
Autor:
Susan J. Gelman, Fuad Naser, Nathaniel G. Mahieu, Lisa D. McKenzie, Gavin P. Dunn, Milan G. Chheda, Gary J. Patti
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 512-522 (2018)
Summary: Gain-of-function mutations in isocitrate dehydrogenase 1 (IDH1) occur in multiple types of human cancer. Here, we show that these mutations significantly disrupt NADPH homeostasis by consuming NADPH for 2-hydroxyglutarate (2-HG) synthesis. C
Externí odkaz:
https://doaj.org/article/04d19f65202b4edbba608a484043e571
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Gavin P. Dunn, Fuad J. Naser, Milan G. Chheda, Susan J. Gelman, Gary J. Patti, Nathaniel G. Mahieu, Lisa D. McKenzie
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 512-522 (2018)
Cell reports
Cell reports
Summary Gain-of-function mutations in isocitrate dehydroge-nase 1 (IDH1) occur in multiple types of human cancer. Here, we show that these mutations significantly disrupt NADPH homeostasis by consuming NADPH for 2-hydroxyglutarate (2-HG) synthesis. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e852ad9c60f77954ffd3e0ff57738313
http://www.sciencedirect.com/science/article/pii/S2211124717318740
http://www.sciencedirect.com/science/article/pii/S2211124717318740
Autor:
Nathaniel G. Mahieu, Gary J. Patti
Publikováno v:
Analytical Chemistry. 89:10397-10406
When using liquid chromatography/mass spectrometry (LC/MS) to perform untargeted metabolomics, it is now routine to detect tens of thousands of features from biological samples. Poor understanding of the data, however, has complicated interpretation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0194f498a7e53376f359a9b87b59fca
https://doi.org/10.1021/acs.analchem.7b02380
https://doi.org/10.1021/acs.analchem.7b02380
Autor:
Manmilan Singh, Xiaojing Huang, Peter A. Crawford, Stephen L. Johnson, Richard W. Gross, Ying Jr Chen, Jacob Schaefer, Nathaniel G. Mahieu, Gary J. Patti
Publikováno v:
Nature chemical biology
It is well established that lactate secreted by fermenting cells can be oxidized or used as a gluconeogenic substrate by other cells and tissues. It is generally assumed, however, that within the fermenting cell itself, lactate is produced to repleni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0155a2275db238f6ce57369d4864bb28
http://europepmc.org/articles/PMC5069139
http://europepmc.org/articles/PMC5069139
Autor:
Gao-Yuan Liu, Gregory S. Potter, Ying-Jr Chen, Manmilan Singh, Gary J. Patti, Nathanial G. Mahieu, Ronald Fowle-Grider, Cong-Hui Yao, Richard W. Gross, Rencheng Wang, Stephen L. Johnson, Jacob Schaefer
Publikováno v:
Cell Chemical Biology. 23:483-493
Cellular proliferation requires the formation of new membranes. It is often assumed that the lipids needed for these membranes are synthesized mostly de novo. Here, we show that proliferating fibroblasts prefer to take up palmitate from the extracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b7f3ae85325c1b657dd2b780d5fd09
https://doi.org/10.1016/j.chembiol.2016.03.007
https://doi.org/10.1016/j.chembiol.2016.03.007
Publikováno v:
Current Opinion in Chemical Biology. 30:87-93
Global profiling of metabolites in biological samples by liquid chromatography/mass spectrometry results in datasets too large to evaluate manually. Fortunately, a variety of software programs are now available to automate the data analysis. Selectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c125de075d96ce4b5aea44d6aead31
https://doi.org/10.1016/j.cbpa.2015.11.009
https://doi.org/10.1016/j.cbpa.2015.11.009
Existing hydrophilic interaction liquid chromatography (HILIC) methods, considered individually, each exhibit poor chromatographic performance for a substantial fraction of polar metabolites. In addition to limiting metabolome coverage, such deficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587b64785804287ca0499628233687da
https://europepmc.org/articles/PMC6427830/
https://europepmc.org/articles/PMC6427830/
