Zobrazeno 1 - 10
of 120
pro vyhledávání: '"G, Luoni"'
Autor:
Isabel Najera, G Luoni, Klaus Klumpp, David Bernard Smith, Sophie Le Pogam, Sinead Mulready, Sonal Rajyaguru, Christopher McGuigan, Mary Rose Kelleher, Plinio Perrone, Felice Daverio, Joseph A. Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4250-4254
We report the design, synthesis and evaluation of a family of ca 50 phosphoramidate ProTides of the potent anti-HCV compound 4'-azidocytidine (R1479), with variation on the ester, amino acid and aryl moiety of the ProTide. Sub-muM inhibitors of HCV e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bae3515770cc9f3e2d172af1e96f5c
https://doi.org/10.1016/j.bmcl.2009.05.099
https://doi.org/10.1016/j.bmcl.2009.05.099
Autor:
Christopher McGuigan, Sheila Srinivasan, Ranjith N. Pathirana, O Bidet, G. Jones, Robert Snoeck, Graciela Andrei, A. Jukes, Jan Balzarini, Andrea Brancale, A Carangio, C. A. Jarvis, E. De Clercq, G Luoni, Sally Blewett, Hubert Barucki
Publikováno v:
Scopus-Elsevier
Bicyclic furano pyrimidine nucleosides have been found to be highly potent and selective inhibitors of varicella zoster virus (VZV). They are inactive against herpes simplex virus and have been known for several decades as (unwanted) synthetic by-pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12470c9122a382bbc1d65f6732c43e10
https://doi.org/10.1177/095632020101200201
https://doi.org/10.1177/095632020101200201
Autor:
Vincenzo Petrarca, G Luoni, Giampietro Corradin, A Chiucchiuini, Fulvio Esposito, D Modiano, B S Sirima, Mario Roggero, Mario Coluzzi
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 61:663-667
We analyzed the humoral immune response to the amino- (amino acids 22-125) and carboxy-terminal (amino acids 289-390) non-repetitive domains of the Plasmodium falciparum circumsporozoite protein (Pf CSP) in individuals belonging to three west African
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27cdf1084f746e85550ddcc781b4ed4
https://doi.org/10.4269/ajtmh.1999.61.663
https://doi.org/10.4269/ajtmh.1999.61.663
Autor:
D Modiano, Mario Coluzzi, B S Sirima, Issa Nebie, Vincenzo Petrarca, Fulvio Esposito, G Luoni
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 59:336-340
It has been shown that insecticide-treated bed nets or curtains may reduce morbidity and mortality from malaria in hyper-holoendemic areas of sub-Saharan Africa. This protection could partially depend on the transitory imbalance between the anti-mala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074d351195caf5ec09ac9069b21c8874
https://doi.org/10.4269/ajtmh.1998.59.336
https://doi.org/10.4269/ajtmh.1998.59.336
Autor:
A Chiucchiuini, Fulvio Esposito, Hedvig Perlmann, D Modiano, Vincenzo Petrarca, G Luoni, B S Sirima, Mario Coluzzi
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 58:220-224
The humoral immune response against synthetic peptides of two Plasmodium falciparum blood-stage antigens, Pf155/ring-infected erythrocyte surface antigen (RESA) (EENV)6 and Pf332 (SVTEEIAEEDK)2, in individ- uals belonging to three sympatric ethnic gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d66bc37e33dc21e21a5554dd955ad91
https://doi.org/10.4269/ajtmh.1998.58.220
https://doi.org/10.4269/ajtmh.1998.58.220
Autor:
Robert Snoeck, Lieve Naesens, Jan Balzarini, Christopher McGuigan, Sonsoles Velázquez, Geoffrey W. Henson, Erik Verbeken, R Adak, Marco Migliore, G Luoni, María-José Camarasa, Rebecca Sienaert, Graciela Andrei, Arwyn Tomos Jones, Ranjith N. Pathirana, Alberto Diez-Torrubia
Publikováno v:
The Journal of antimicrobial chemotherapy. 60(6)
To progress the anti-varicella-zoster-virus (VZV) aryl bicyclic nucleoside analogues (BCNAs) to the point of Phase 1 clinical trial for herpes zoster.A new chromatography-free synthetic access to the lead anti-VZV aryl BCNAs is reported. The anti-VZV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e6ef2785a2398d02362042ac2ec308
https://pubmed.ncbi.nlm.nih.gov/17956908
https://pubmed.ncbi.nlm.nih.gov/17956908
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(16)
Further to the discovery of bicyclic furanopyrimidine nucleoside analogues (BCNAs) as potent anti-VZV agents, a branched series of this family of compounds was synthesised. The aim was to study the impact of the geometry and steric hindrance in the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e1c51995208b4886f4ef8874b2bad4
https://pubmed.ncbi.nlm.nih.gov/15993062
https://pubmed.ncbi.nlm.nih.gov/15993062
Publikováno v:
ChemInform. 35
We have recently discovered bicyclic furopyrimidines as potent and selective inhibitors of VZV. In order to investigate the structural requirements for antiviral activity we have succesfully synthesised some 3′-chloro and 5′-chloro derivatives. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc5d1f8e76de62abfddc06f0c2da2ad1
https://doi.org/10.1002/chin.200405190
https://doi.org/10.1002/chin.200405190
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 22(5-8)
We have recently discovered bicyclic furopyrimidines as potent and selective inhibitors of VZV. In order to investigate the structural requirements for antiviral activity we have succesfully synthesised some 3′-chloro and 5′-chloro derivatives. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c5fe23242d41a1f32e0d2883b13cab
https://pubmed.ncbi.nlm.nih.gov/14565314
https://pubmed.ncbi.nlm.nih.gov/14565314
Autor:
D, Modiano, G, Luoni, V, Petrarca, B, Sodiomon Sirima, M, De Luca, J, Simporé, M, Coluzzi, J G, Bodmer, G, Modiano
Publikováno v:
Tissue antigens. 57(2)
Fulani of Burkina Faso (West Africa) are a particularly interesting ethnic group because of their lower susceptibility to Plasmodium falciparum malaria as compared to sympatric populations, Mossi and Rimaibé. Moreover, the occurrence of a Caucasoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a10c5399bd10761b5016725395758986
https://pubmed.ncbi.nlm.nih.gov/11260507
https://pubmed.ncbi.nlm.nih.gov/11260507