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Complexation of zolpidem with 2-hydroxypropyl-beta-, methyl-beta-, and 2-hydroxypropyl-gamma-cyclodextrin: effect on aqueous solubility, dissolution rate, and ataxic activity in rat

Autor: G, Trapani, A, Latrofa, M, Franco, M R, Pantaleo, E, Sanna, F, Massa, F, Tuveri, G, Liso

Publikováno v: Journal of pharmaceutical sciences. 89(11)

The effect of some chemically modified cyclodextrins [namely, 2-hydroxypropyl-beta-, methyl-beta-, and 2-hydroxypropyl-gamma-cyclodextrin (HP-beta-CD, Me-beta-CD, and HP-gamma-CD, respectively)] on the aqueous solubility and dissolution rate of the h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::765d0a3d4fec0e1c88b9c1f6fefc057b
https://pubmed.ncbi.nlm.nih.gov/11015689

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2-Phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: stimulation of neurosteroid synthesis and anticonflict action in rats

Autor: M, Serra, P, Madau, M F, Chessa, M, Caddeo, E, Sanna, G, Trapani, M, Franco, G, Liso, R H, Purdy, M L, Barbaccia, G, Biggio

Publikováno v: British journal of pharmacology. 127(1)

Selective activation of peripheral benzodiazepine receptors (PBRs) in adrenal cells and brain oligodendrocytes promotes steroidogenesis. Three 2-phenyl-imidazo[1,2-a]pyridine derivatives (CB 34, CB 50 and CB 54) have now been investigated with regard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76f0cfa2f0beabf4cabf00f3fe5fcb11
https://pubmed.ncbi.nlm.nih.gov/10369471

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Inclusion complexation of propofol with 2-hydroxypropyl-beta-cyclodextrin. Physicochemical, nuclear magnetic resonance spectroscopic studies, and anesthetic properties in rat. trapani@ippo.uniba.it

Autor: G, Trapani, A, Latrofa, M, Franco, A, Lopedota, E, Sanna, G, Liso

Publikováno v: Journal of pharmaceutical sciences. 87(4)

An aqueous formulations of propofol 1 can be prepared by solubilizing it in the presence of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD). This is potentially useful for parenteral administration of the drug. The aqueous solubility of 1 linearly inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0bb04c9362f3b11fa1431b47364f763b
https://pubmed.ncbi.nlm.nih.gov/9548907

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Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type

Autor: G, Trapani, M, Franco, L, Ricciardi, A, Latrofa, G, Genchi, E, Sanna, F, Tuveri, E, Cagetti, G, Biggio, G, Liso

Publikováno v: Journal of medicinal chemistry. 40(19)

A number of 6-substituted or 6,8-disubstituted alkyl 2-phenylimidazo[1,2-alpha]pyridine-3-carboxylates 5a-h, -acetates 5i-s, 6a-g, and -propionates 5t, 6h and of N,N-dialkyl-2-phenylimidazo[1,2-alpha]pyridine-3-carboxamides 7a-d,-acetamides 7e-t or -

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8f87278d495d6059002ed5b3d4d1db3
https://pubmed.ncbi.nlm.nih.gov/9301675

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Synthesis of 2-substituted-N-carboxymethyl-1,5-benzothiazepin-4-ones and -1,4-benzothiazin-3-ones and their evaluation as angiotensin converting enzyme inhibitors

Autor: G, Trapani, A, Latrofa, M, Franco, G, Liso

Publikováno v: Farmaco (Societa chimica italiana : 1989). 50(2)

The title compounds 7a-d and 8a-e were synthesized and their in vitro inhibitory activity of angiotensin-converting enzyme (ACE) was examined. In general, these compounds possess poor ACE inhibitory activity. Among the benzothiazinone compounds, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::991c5a03589c53e116c5cfbde8eb24ac
https://pubmed.ncbi.nlm.nih.gov/7766274

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Synthesis and antimicrobial activity of some N-alkenyl-2-acylalkylidene-2,3-dihydro-1,3-benzothiazoles

Autor: G, Trapani, A, Latrofa, M, Franco, D, Armenise, F, Morlacchi, G, Liso

Publikováno v: Arzneimittel-Forschung. 44(8)

Several N-alkenyl-2-acylalkylidene-2,3-dihydro-1,3-benzothiazoles (4) were synthesized and tested for in vitro antibacterial activity against different Gram-positive and Gram-negative bacteria. Compounds 4 were also tested for antifungal activity aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0268074424b127f3ce37bd51f707d38e
https://pubmed.ncbi.nlm.nih.gov/7945544

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Synthesis and benzodiazepine receptor binding of 1H-pyrrolo[2,1-C][1,4]benzothiazines

Autor: G, Trapani, A, Latrofa, M, Franco, G, Liso, G, Genchi

Publikováno v: Farmaco (Societa chimica italiana : 1989). 45(6)

The pyrrolo[2,1-c][1,4]benzothiazines 2a-n and the pyrrolo[2,1-c][1,4]thiazine 13 were prepared and tested for their ability to displace specific [3H]diazepam binding from rat brain membranes. Such compounds were found essentially devoid of binding a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::959d383d87f91690733ad9751ea0caa9
https://pubmed.ncbi.nlm.nih.gov/2176785

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Synthesis and benzodiazepine receptor binding of 5H-pyrido[2,1-C][1,4]benzothiazines

Autor: G, Trapani, A, Latrofa, M, Franco, G, Liso, G, Genchi

Publikováno v: Farmaco (Societa chimica italiana : 1989). 45(6)

The pyrido[2,1-c][1,4]benzothiazines 1a-t and the pyrido[2,1-c][1,4]thiazines 7a,b were prepared and tested for their ability to displace specific [3H]diazepam binding from rat brain membranes. Some of the examined compounds of type 1 and 7b showed m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d6ca07bf66289f9aea3fd15b4d83dd1b
https://pubmed.ncbi.nlm.nih.gov/2176786

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