Zobrazeno 1 - 10
of 4 042
pro vyhledávání: '"G, Kovacs"'
Autor:
Tomoya Kon, Shelley L. Forrest, Seojin Lee, Jun Li, Helen Chasiotis, Nasna Nassir, Mohammed J. Uddin, Anthony E. Lang, Gabor G. Kovacs
Publikováno v:
Neurobiology of Disease, Vol 198, Iss , Pp 106551- (2024)
Multiple system atrophy (MSA) is characterized by glial cytoplasmic inclusions (GCIs) containing aggregated α-synuclein (α-syn) in oligodendrocytes. The origin of α-syn accumulation in GCIs is unclear, in particular whether abnormal α-syn aggrega
Externí odkaz:
https://doaj.org/article/9f8e98dda3ed4320bd4654f1648f7e33
Publikováno v:
Neurobiology of Disease, Vol 197, Iss , Pp 106535- (2024)
Background: Multiple system atrophy (MSA) is a primary oligodendroglial synucleinopathy, characterized by elevated iron burden in early-affected subcortical nuclei. Although neurotoxic effects of brain iron deposition and its relationship with α-syn
Externí odkaz:
https://doaj.org/article/7245cad3705c4261b4f9c48b69aabbc0
Autor:
Huihui Luo, Emil K. Gustavsson, Hannah Macpherson, Natalia Dominik, Kristina Zhelcheska, Kylie Montgomery, Claire Anderson, Wai Yan Yau, Stephanie Efthymiou, Chris Turner, Michael DeTure, Dennis W. Dickson, Keith A. Josephs, Tamas Revesz, Tammaryn Lashley, Glenda Halliday, Dominic B. Rowe, Emily McCann, Ian Blair, Andrew J. Lees, Pentti J. Tienari, Anu Suomalainen, Laura Molina-Porcel, Gabor G. Kovacs, Ellen Gelpi, John Hardy, Matti J. Haltia, Arianna Tucci, Zane Jaunmuktane, Mina Ryten, Henry Houlden, Zhongbo Chen
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-6 (2024)
Externí odkaz:
https://doaj.org/article/66ce109f71ec44af9981960c060d30a1
Autor:
Tomoya Kon, Shelley L. Forrest, Seojin Lee, Ivan Martinez‑Valbuena, Jun Li, Nasna Nassir, Mohammed J. Uddin, Anthony E. Lang, Gabor G. Kovacs
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Misfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body disease (LBD) based on considerable evidence including a gene-dosage effect observed in relation to point mutations and multiplication of SNCA in fam
Externí odkaz:
https://doaj.org/article/3f5a20111e77431e98b04a082450b8fc
Autor:
S. Behr, F. Fenski, J. Boettcher, C. Knaevelsrud, L. Hammelrath, G. Kovacs, W. Schirmer, H. Petrick, P. Becker, C. Schaeuffele
Publikováno v:
Internet Interventions, Vol 35, Iss , Pp 100723- (2024)
Background: Internet-based interventions offer a way to meet the high demand for psychological support. However, this setting also has disadvantages, such as the lack of personal contact and the limited ability to respond to crises. Blended care comb
Externí odkaz:
https://doaj.org/article/84066030c08243a4bd059799c0ca82f2
Autor:
Yuriko Katsumata, Xian Wu, Khine Zin Aung, Kathryn Gauthreaux, Charles Mock, Shelley L. Forrest, Gabor G. Kovacs, Peter T. Nelson
Publikováno v:
Neurobiology of Disease, Vol 191, Iss , Pp 106412- (2024)
Age-related tau astrogliopathy (ARTAG) is detectable in the brains of over one-third of autopsied persons beyond age 80, but the pathoetiology of ARTAG is poorly understood. Insights can be gained by analyzing risk factors and comorbid pathologies. H
Externí odkaz:
https://doaj.org/article/b09d3c3c4f3e44208b36bf1f0ebae65c
Autor:
Heather H. C. Lau, Ivan Martinez-Valbuena, Raphaella W. L. So, Surabhi Mehra, Nicholas R. G. Silver, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T. Hyman, Martin Ingelsson, Gabor G. Kovacs, Joel C. Watts
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Unique strains of α-synuclein aggregates have been postulated to underlie the spectrum of clinical and pathological presentations seen across the synucleinopathies. Whereas multiple system atrophy (MSA) is associated with a predominance of
Externí odkaz:
https://doaj.org/article/0a11f0c8776346f5aa6f04e52680ec2e
Autor:
Holger Hummerich, Helen Speedy, Tracy Campbell, Lee Darwent, Elizabeth Hill, Steven Collins, Christiane Stehmann, Gabor G Kovacs, Michael D Geschwind, Karl Frontzek, Herbert Budka, Ellen Gelpi, Adriano Aguzzi, Sven J van der Lee, Cornelia M van Duijn, Pawel P Liberski, Miguel Calero, Pascual Sanchez-Juan, Elodie Bouaziz-Amar, Jean-Louis Laplanche, Stéphane Haïk, Jean-Phillipe Brandel, Angela Mammana, Sabina Capellari, Anna Poleggi, Anna Ladogana, Maurizio Pocchiari, Saima Zafar, Stephanie Booth, Gerard H Jansen, Aušrinė Areškevičiūtė, Eva Løbner Lund, Katie Glisic, Piero Parchi, Peter Hermann, Inga Zerr, Brian S Appleby, Jiri Safar, Pierluigi Gambetti, John Collinge, Simon Mead
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0304528 (2024)
Human prion diseases are rare, transmissible and often rapidly progressive dementias. The most common type, sporadic Creutzfeldt-Jakob disease (sCJD), is highly variable in clinical duration and age at onset. Genetic determinants of late onset or slo
Externí odkaz:
https://doaj.org/article/a8105e366d44473aa02be9676f81d759
Autor:
Zachary N. Harris, Julia E. Pratt, Laszlo G. Kovacs, Laura L. Klein, Misha T. Kwasniewski, Jason P. Londo, Angela S. Wu, Allison J. Miller
Publikováno v:
BMC Plant Biology, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Background Grafting is a horticultural practice used widely across woody perennial crop species to fuse together the root and shoot system of two distinct genotypes, the rootstock and the scion, combining beneficial traits from both. In grap
Externí odkaz:
https://doaj.org/article/28423309d66d4d2f8db0a4e58135842e
Autor:
Seojin Lee, Gabor G. Kovacs
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4269 (2024)
Iron accumulation in the brain is a common feature of many neurodegenerative diseases. Its involvement spans across the main proteinopathies involving tau, amyloid-beta, alpha-synuclein, and TDP-43. Accumulating evidence supports the contribution of
Externí odkaz:
https://doaj.org/article/c2ea3fb1bd0643a18be035c3d226dc3a