Zobrazeno 1 - 10 of 80 pro vyhledávání: '"G, Kirigi"'
1
Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study
Autor: Simon Njenga, G. Kirigi, Asrat Hailu, Ahmed Eleojo Musa, Monique Wasunna, Joseph Olobo, Thomas P. C. Dorlo, Manica Balasegaram, Eltahir A G Khalil, Mats O. Karlsson, Anke E. Kip, Brima M. Younis, Jos H. Beijnen, Fabiana Alves, Sally Ellis
Publikováno v: Journal of Antimicrobial Chemotherapy
Background: Low efficacy of miltefosine in the treatment of visceral leishmaniasis was recently observed in Eastern Africa. Objectives: To describe the pharmacokinetics and establish a pharmacokinetic/pharmacodynamic relationship for miltefosine in E
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e370f56f0e35af7a84f95c232cbafbe
http://europepmc.org/articles/PMC5890687
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2
Pharmacokinetics, Safety, and Efficacy of an Allometric Miltefosine Regimen for the Treatment of Visceral Leishmaniasis in Eastern African Children: An Open-label, Phase II Clinical Trial
Autor: Jorge Alvar, Thaddaeus Egondi, Alexandra Solomos, Joseph Olobo, Anke E. Kip, Lilian Were, Truphosa Omollo, Patrick Sagaki, G. Kirigi, Fabiana Alves, Thomas P. C. Dorlo, Robert Kimutai, Jane Mbui, Monique Wasunna, Raymond Omollo
Publikováno v: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background Convenient, safe, and effective treatments for visceral leishmaniasis in Eastern African children are lacking. Miltefosine, the only oral treatment, failed to achieve adequate efficacy, particularly in children, in whom linear dosing (2.5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084a183a8887aa07ddc3e2e7ab4a4753
https://pubmed.ncbi.nlm.nih.gov/30188978
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3
Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial
Autor: Manica Balasegaram, Neal Alexander, Anke E. Kip, Mohammed Hassan Sharaf Ali, Eltahir A G Khalil, Gerard J. Schoone, Simon Njenga, Sally Ellis, Susan Wells, Thomas P. C. Dorlo, Robert Kimutai, Monique Wasunna, Joseph Olobo, Asrat Hailu, Fabiana Alves, Raymond Omollo, Brima Musa, Nathalie Strub Wourgaft, Mohammed Yasein Elamin, G. Kirigi, Ahmed Eleojo Musa, Rashid Juma, Tansy Edwards
Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004880 (2016)
PLoS Neglected Tropical Diseases, 10(9), 1. Public Library of Science
PLoS Neglected Tropical Diseases
Background SSG&PM over 17 days is recommended as first line treatment for visceral leishmaniasis in eastern Africa, but is painful and requires hospitalization. Combination regimens including AmBisome and miltefosine are safe and effective in India,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40948c6b3808f106f5666edd27cf699
http://europepmc.org/articles/PMC5023160?pdf=render
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4
Identification ofLeishmania tropicafrom micro-foci of cutaneous leishmaniasis in the Kenyan Rift Valley
Autor: Alfred Muia, Charles Magiri, Gert Van der Auwera, G. Kirigi, Margaret Mbuchi, Jean-Claude Dujardin, Ilse Maes, Monique Wasunna, Samwel Odiwuor
Publikováno v: Pathogens and global health
We performed diagnosis and species identification of parasites in lesion samples from suspected cutaneous leishmaniasis patients in four villages, three of which are in a known Leishmania tropica endemic region in Kenya. Samples were analyzed both by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4429ea5f50ce4d5b72c8f499fe56825
https://doi.org/10.1179/2047773212y.0000000015
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5
Sensitivity and specificity of theLeishmaniaOligoC-TesT and NASBA-oligochromatography for diagnosis of visceral leishmaniasis in Kenya
Autor: Frank L. Basiye, Gerard J. Schoone, Charles Magiri, Enock Matovu, G. Kirigi, Stijn Deborggraeve, Margaret Mbuchi, Alfarazdeg A. Saad, Monique Wasunna, Sayda El-Safi
Publikováno v: Tropical Medicine & International Health. 15:806-810
NASBA-OC were 79.8% (95% CI: 67‐87%) and 100% (95% CI: 96.3‐100%), respectively. conclusion Our findings indicate high sensitivity of the Leishmania OligoC-TesT on blood while the NASBA-OC is a better marker for active disease.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51333b4dfff644d6552c592f26221e17
https://doi.org/10.1111/j.1365-3156.2010.02548.x
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6
SPATIAL CLUSTERING AND EPIDEMIOLOGICAL ASPECTS OF VISCERAL LEISHMANIASIS IN TWO ENDEMIC VILLAGES, BARINGO DISTRICT, KENYA
Autor: Samuel K. Martin, J. R. Rashid, Christian T. Bautista, Jeffrey R. Ryan, Monique Wasunna, Dedan Kinoti, Charles Magiri, Shadrak O. Odera, Jane Mbui, Adeline S. T. Chan, Lisa P. Hochberg, Phillip M. Ngumbi, G. Kirigi
Publikováno v: The American Journal of Tropical Medicine and Hygiene. 74:308-317
Visceral leishmaniasis (VL) seroprevalence in Kenya is unknown because of the lack of a practical and accurate diagnostic test or surveillance system. A novel serological assay was used to estimate the seroprevalence of Leishmania-specific antibodies
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94bec9a9b94c4ab556b453918c062fd0
https://doi.org/10.4269/ajtmh.2006.74.308
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7
Evaluation of a standardized direct agglutination test (DAT) for the diagnosis of visceral leishmaniasis in Kenya
Autor: F. Kibati, J.I. Githure, J. M. Kagai, D.K. Koech, Mbati Pa, G. Kirigi, Wasunna Km
Publikováno v: Annals of Tropical Medicine And Parasitology. 93:703-710
A prototype test kit being developed, by the World Health Organization (WHO), for the diagnosis of visceral leishmaniasis (VL) was evaluated in the Baringo district of Rift Valley province in Kenya. The screening of approximately 10 000 individuals f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9a5c1bd0a486beac2b9150c51e097c
https://doi.org/10.1080/00034989957952
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8
The effect of sodium bicarbonate on a single dose of diethylcarbamazine therapy in patients with bancroftian filariasis in Kenya
Autor: J. Mbugua, G. Kirigi, Yoshiki Aoki, Sammy M. Njenga, Yasunori Fujimaki, Mugo Muita, G.S. Gachihi, Yoshinori Mitsui, Monique Wasunna
Publikováno v: Parasitology International. 46:171-179
An attempt was made to examine the effect of a combination of diethylcarbamazine citrate (DEC-C) and sodium bicarbonate (NaHCO3) on the pharmacokinetics of diethylcarbamazine (DEC), side-reactions and reduction of the microfilarial density of patient
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4cfb24ca2d6cca1c8af055410dccfb4
https://doi.org/10.1016/s1383-5769(97)00026-3
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9
A successful treatment of a Kenyan case of unresponsive cutaneous leishmaniasis with a combination of pentostam and oral allopurinol: case report
Autor: G, Kirigi, M W, Mbuchi, J K, Mbui, J R, Rashid, D M, Kinoti, S N, Njoroge, F, Basiye, C, Magiri, M K, Wasunna
Publikováno v: East African medical journal. 87(12)
A nine year aged male presented with facial lesions and the problem of responding to conventional treatment of leishmaniasis. Multiple injections of antimony and several topical ointments had been administered in hospital but fresh lesions erupted wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a60e8ebfbac63968afbe3ca0359ca19
https://pubmed.ncbi.nlm.nih.gov/23457863
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10
Validation of two rapid diagnostic tests for visceral leishmaniasis in Kenya
Autor: Manica Balasegaram, Joke van Peteghem, Roberto de la Tour, Mark Riongoita, Rashid Juma, G. Kirigi, Simon Njenga, Adrian Laussermayer, François Chappuis, Raymond Omollo, Jane Mbui, Monique Wasunna
Publikováno v: PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases, Vol. 7, No 9 (2013) P. e2441
PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2441 (2013)
Background Visceral leishmaniasis (VL) is a systemic parasitic disease that is fatal unless treated. In Kenya, national VL guidelines rely on microscopic examination of spleen aspirate to confirm diagnosis. As this procedure is invasive, it cannot be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693ee7fad4f160b45c77e559f48ead26
https://pubmed.ncbi.nlm.nih.gov/24086782
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