Zobrazeno 1 - 10
of 38
pro vyhledávání: '"G, Khalafalla"'
Autor:
Yue Li, Ashley Duche, Michael R. Sayer, Don Roosan, Farid G. Khalafalla, Rennolds S. Ostrom, Jennifer Totonchy, Moom R. Roosan
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background The ongoing COVID-19 outbreak has caused devastating mortality and posed a significant threat to public health worldwide. Despite the severity of this illness and 2.3 million worldwide deaths, the disease mechanism is mostly unkno
Externí odkaz:
https://doaj.org/article/ddecfce575344945b0ca7c9a16bb82a4
Autor:
Thao N.D. Pham, Christina Spaulding, Mario A. Shields, Anastasia E. Metropulos, Dhavan N. Shah, Mahmoud G. Khalafalla, Daniel R. Principe, David J. Bentrem, Hidayatullah G. Munshi
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
To elicit effective antitumor responses, CD8+ T cells need to infiltrate tumors and sustain their effector function within the immunosuppressive tumor microenvironment (TME). Here, we evaluate the role of MNK activity in regulating CD8+ T cell infilt
Externí odkaz:
https://doaj.org/article/1a09d8a5ba8e4f9fab3e3efe9e16fad1
Autor:
Mahmoud G. Khalafalla, Lucas T. Woods, Kimberly J. Jasmer, Kevin Muñoz Forti, Jean M. Camden, Janicke L. Jensen, Kirsten H. Limesand, Hilde K. Galtung, Gary A. Weisman
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral cavity, facilitating taste sensation and digestion and maintaining tooth enamel. Therefore, saliv
Externí odkaz:
https://doaj.org/article/a2dca1737cb34136b4dfa4310d80b2cd
Publikováno v:
Biochimica et biophysica acta. Reviews on cancer. 1877(3)
Despite recent advances in the treatment landscape for prostate cancer, many challenges still remain. A more profound understanding of prostate cancer pathogenesis and the underlying mechanisms is critical to developing novel therapeutics strategies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a4857496f2280f943825ae20c31a66
https://pubmed.ncbi.nlm.nih.gov/35483490
https://pubmed.ncbi.nlm.nih.gov/35483490
Autor:
Lucas T Woods, Jean M Camden, Farid G El-Sayed, Mahmoud G Khalafalla, Michael J Petris, Laurie Erb, Gary A Weisman
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0123641 (2015)
Transforming growth factor-β (TGF-β) is a multi-functional cytokine with a well-described role in the regulation of tissue fibrosis and regeneration in the liver, kidney and lung. Submandibular gland (SMG) duct ligation and subsequent deligation in
Externí odkaz:
https://doaj.org/article/ef6716bf45674d6489c3c78a66c7d69e
Autor:
Robert M. Adamson, Mark A. Sussman, Dieter A Kubli, Fareheh Firouzi, Bingyan J. Wang, Megan M. Monsanto, Farid G. Khalafalla, Åsa B. Gustafsson, Kelli Korski, Walter P. Dembitsky, Taeyong Kim, Oscar Echeagaray
Publikováno v:
Stem Cells. 37:555-567
Senescence-associated dysfunction deleteriously affects biological activities of human c-Kit+ cardiac progenitor cells (hCPCs), particularly under conditions of in vitro culture. In comparison, preservation of self-renewal and decreases in mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecd4459ce84d05713f12bae8d02fad56
https://doi.org/10.1002/stem.2970
https://doi.org/10.1002/stem.2970
Gα13 loss promotes tumor progression in the KPC transgenic mouse model of advanced pancreatic cancer
Autor:
Hidayatullah G. Munshi, Christina Spaulding, Mahmoud G. Khalafalla, Thao Pham, Mario A. Shields
SUMMARYGα13 transduces signals from G protein-coupled receptors. Gα13 is pro-tumorigenic in epithelial cancer cell lines, which contrasts with its tumor-suppressive function in transgenic mouse models of lymphomas. Here we show that while loss of G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375c5a5528a095d2748376555aa21822
https://doi.org/10.1101/2021.03.15.435488
https://doi.org/10.1101/2021.03.15.435488
Autor:
Jennifer Totonchy, Michael R. Sayer, Moom R. Roosan, Farid G. Khalafalla, Rennolds S. Ostrom, Yue Li, Ashley Duche, Don Roosan
Publikováno v:
BMC Genomics
BMC Genomics, Vol 22, Iss 1, Pp 1-13 (2021)
BMC Genomics, Vol 22, Iss 1, Pp 1-13 (2021)
Background The ongoing COVID-19 outbreak has caused devastating mortality and posed a significant threat to public health worldwide. Despite the severity of this illness and 2.3 million worldwide deaths, the disease mechanism is mostly unknown. Previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0899fa0a9c3b0d04d81cf3b0272498
https://pubmed.ncbi.nlm.nih.gov/33602138
https://pubmed.ncbi.nlm.nih.gov/33602138
Autor:
Mario A. Shields, Christina Spaulding, Anastasia E. Metropulos, Mahmoud G. Khalafalla, Thao N.D. Pham, Hidayatullah G. Munshi
Publikováno v:
Cell Reports. 38:110441
Gα13 transduces signals from G-protein-coupled receptors. While Gα13 functions as a tumor suppressor in lymphomas, it is not known whether Gα13 is pro-tumorigenic or tumor suppressive in genetically engineered mouse (GEM) models of epithelial canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca934e9573f66f19e8a5c94c65e528a
https://doi.org/10.1016/j.celrep.2022.110441
https://doi.org/10.1016/j.celrep.2022.110441
Autor:
Megan M. Monsanto, Veronica Sacchi, Christina R. Payne, Natalie Gude, Walter P. Dembitsky, Kristine Nguyen, Fareheh Firouzi, David E. Ebeid, Barbara A. Bailey, Jop H. van Berlo, Mark A. Sussman, Alexandria Casillas, Farid G. Khalafalla, Roberto Alvarez, Kathleen M. Broughton, Kelli Ilves, Bingyan J. Wang
Publikováno v:
Circulation Research. 123:57-72
Rationale: Biological significance of c-Kit as a cardiac stem cell marker and role(s) of c-Kit+ cells in myocardial development or response to pathological injury remain unresolved because of varied and discrepant findings. Alternative experimental m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c14256900de781ebedc989826a126ed
https://doi.org/10.1161/circresaha.117.311828
https://doi.org/10.1161/circresaha.117.311828