Zobrazeno 1 - 10
of 1 015
pro vyhledávání: '"G, Hubert"'
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002295 (2023)
Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigen
Externí odkaz:
https://doaj.org/article/3c78a5a10ba144b49943c87807187a2a
Autor:
Alice-Roza Eruera, Alice M. McSweeney, Geena M. McKenzie-Goldsmith, Helen K. Opel-Reading, Simone X. Thomas, Ashley C. Campbell, Louise Stubbing, Andrew Siow, Jonathan G. Hubert, Margaret A. Brimble, Vernon K. Ward, Kurt L. Krause
Publikováno v:
Viruses, Vol 15, Iss 11, p 2202 (2023)
Norovirus is the leading cause of viral gastroenteritis worldwide, and there are no approved vaccines or therapeutic treatments for chronic or severe norovirus infections. The structural characterisation of the norovirus protease and drug development
Externí odkaz:
https://doaj.org/article/86ca3c78c4f045989589594a543e6b57
Autor:
Sajina Shakya, Anthony D. Gromovsky, James S. Hale, Arnon M. Knudsen, Briana Prager, Lisa C. Wallace, Luiz O. F. Penalva, H. Alex Brown, Bjarne W. Kristensen, Jeremy N. Rich, Justin D. Lathia, J. Mark Brown, Christopher G. Hubert
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Glioblastoma (GBM) displays marked cellular and metabolic heterogeneity that varies among cellular microenvironments within a tumor. Metabolic targeting has long been advocated as a therapy against many tumors including GBM, but how lipid me
Externí odkaz:
https://doaj.org/article/f740fb738c5c45e4ad68a8ab8f9b28c9
Autor:
Christopher Hubert, Kelly Mitchell, Samuel Sprowls, Sajina Shakya, Sonali Arora, Daniel J. Silver, Christopher M. Goins, Lisa Wallace, Gustavo Roversi, Rachel Schafer, Kristen Kay, Tyler E. Miller, Adam Lauko, John Bassett, Anjali Kashyap, J. D’Amato Kass, Erin E. Mulkearns-Hubert, Sadie Johnson, Joseph Alvarado, Jeremy N. Rich, Patrick J. Paddison, Anoop P. Patel, Shaun R. Stauffer, Christopher G. Hubert, Justin D. Lathia
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 107-107 (2023)
OBJECTIVES/GOALS: Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors that are driven by populations of cancer stem cells (CSCs). In this study, we perform an epigenetic-focused functional genomics screen in GBM organoids and identify
Externí odkaz:
https://doaj.org/article/38b0f34846504b9fac37c7e24f076612
Autor:
Swetha J. Sundar, Sajina Shakya, Austin Barnett, Lisa C. Wallace, Hyemin Jeon, Andrew Sloan, Violette Recinos, Christopher G. Hubert
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101251- (2022)
Background: Glioblastoma (GBM) is the most common primary brain tumor with a dismal prognosis. The inherent cellular diversity and interactions within tumor microenvironments represent significant challenges to effective treatment. Traditional cultur
Externí odkaz:
https://doaj.org/article/7a95975469164d588ba4aae539bafb71
Autor:
Kelly Mitchell, Samuel A. Sprowls, Sonali Arora, Sajina Shakya, Daniel J. Silver, Christopher M. Goins, Lisa Wallace, Gustavo Roversi, Rachel E. Schafer, Kristen Kay, Tyler E. Miller, Adam Lauko, John Bassett, Anjali Kashyap, Jonathan D'Amato Kass, Erin E. Mulkearns-Hubert, Sadie Johnson, Joseph Alvarado, Jeremy N. Rich, Eric C. Holland, Patrick J. Paddison, Anoop P. Patel, Shaun R. Stauffer, Christopher G. Hubert, Justin D. Lathia
Publikováno v:
Genes & Development. 37:86-102
Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors driven by populations of cancer stem cells (CSCs). However, few molecular mechanisms critical for CSC population maintenance have been exploited for therapeutic development. We develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceec354fa1d7b6ded682eadfc70abc81
https://doi.org/10.1101/gad.349803.122
https://doi.org/10.1101/gad.349803.122
Autor:
Julie A. Shields, Samuel R. Meier, Madhavi Bandi, Erin E. Mulkearns-Hubert, Nicole Hajdari, Maria Dam Ferdinez, Justin L. Engel, Daniel J. Silver, Binzhang Shen, Wenhai Zhang, Christopher G. Hubert, Kelly Mitchell, Sajina Shakya, Shan-Chuan Zhao, Alborz Bejnood, Minjie Zhang, Robert Tjin Tham Sjin, Erik Wilker, Justin D. Lathia, Jannik N. Andersen, Yingnan Chen, Fang Li, Barbara Weber, Alan Huang, Natasha Emmanuel
Publikováno v:
Cancer Research. 82:4044-4057
Synthetic lethality is a genetic interaction that results in cell death when two genetic deficiencies co-occur but not when either deficiency occurs alone, which can be co-opted for cancer therapeutics. Pairs of paralog genes are among the most strai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c433b7ec0aefccb7663e6e6ed47282b
https://doi.org/10.1158/0008-5472.can-21-4443
https://doi.org/10.1158/0008-5472.can-21-4443
Autor:
Patrick J. Paddison, James M. Olson, Jennifer DeLuca, Jeongwu Lee, Jun Zhu, Jeffery J. Delrow, Do-Hyun Nam, Steven M. Pollard, Jennifer K. Risler, Bin Zhang, Ryan Basom, Julio Vazquez, Kyobi Skutt-Kakaria, Chad M. Toledo, Philip Corrin, Jacob Herman, Christopher G. Hubert, Yu Ding
PDF file - 340K, Effects of BUB1B knockdown on in human astrocytes, RasV12 transformed astrocytes, Hela cells and RPE-1 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe24a60919136f4747f8f0b1a65d208
https://doi.org/10.1158/2159-8290.22528634.v1
https://doi.org/10.1158/2159-8290.22528634.v1
Autor:
Patrick J. Paddison, James M. Olson, Jennifer DeLuca, Jeongwu Lee, Jun Zhu, Jeffery J. Delrow, Do-Hyun Nam, Steven M. Pollard, Jennifer K. Risler, Bin Zhang, Ryan Basom, Julio Vazquez, Kyobi Skutt-Kakaria, Chad M. Toledo, Philip Corrin, Jacob Herman, Christopher G. Hubert, Yu Ding
PDF file - 133K, BTIC and NSC growth phenotypes resulting from knockdown of PLK1 and pharmacological inhibition of Aurora B kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673e2e8ca2659fa7af9eddc7b03bf001
https://doi.org/10.1158/2159-8290.22528652
https://doi.org/10.1158/2159-8290.22528652
Autor:
Patrick J. Paddison, James M. Olson, Jennifer DeLuca, Jeongwu Lee, Jun Zhu, Jeffery J. Delrow, Do-Hyun Nam, Steven M. Pollard, Jennifer K. Risler, Bin Zhang, Ryan Basom, Julio Vazquez, Kyobi Skutt-Kakaria, Chad M. Toledo, Philip Corrin, Jacob Herman, Christopher G. Hubert, Yu Ding
PDF file - 134K, Ras-Mapk signaling is inappropriately high BTICs and NHA-Ras cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0744c91c84ce02fc2c9cd633d3fb72a3
https://doi.org/10.1158/2159-8290.22528631
https://doi.org/10.1158/2159-8290.22528631