Zobrazeno 1 - 10
of 2 691
pro vyhledávání: '"G, Horvath"'
Autor:
Yunjian Wu, Kimberley C. Clark, Birunthi Niranjan, Anderly C. Chüeh, Lisa G. Horvath, Renea A. Taylor, Roger J. Daly
Publikováno v:
Molecular Oncology, Vol 17, Iss 3, Pp 469-486 (2023)
Reciprocal interactions between prostate cancer cells and carcinoma‐associated fibroblasts (CAFs) mediate cancer development and progression; however, our understanding of the signalling pathways mediating these cellular interactions remains incomp
Externí odkaz:
https://doaj.org/article/fb4d4761774743f4b0ba57a74bdb924f
Autor:
Heidi Fettke, Chao Dai, Edmond M. Kwan, Tiantian Zheng, Pan Du, Nicole Ng, Patricia Bukczynska, Maria Docanto, Louise Kostos, Siavash Foroughi, Stephen Brown, Lisa-Jane K. Graham, Kate Mahon, Lisa G. Horvath, Shidong Jia, Manish Kohli, Arun A. Azad
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104738- (2023)
Summary: Background: Genomic alterations in DNA damage response (DDR) genes are common in metastatic castration-resistant prostate cancer (mCRPC). Understanding how these genomic events impact prognosis and/or treatment response is vital for optimisi
Externí odkaz:
https://doaj.org/article/868bde2315c940f2aff0e43052a1b905
Autor:
Elizabeth A. Connolly, Peter S. Grimison, Lisa G. Horvath, Phillip J. Robinson, Roger R. Reddel
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Sarcoma is a rare and complex disease comprising over 80 malignant subtypes that is frequently characterized by poor prognosis. Challenges in clinical management include uncertainties in diagnosis and disease classification, limited prognostic and pr
Externí odkaz:
https://doaj.org/article/ac995c1cdc4c44b3bedb06302910ae0c
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Despite key advances in the treatment of prostate cancer (PCa), a proportion of men have de novo resistance, and all will develop resistance to current therapeutics over time. Aberrant lipid metabolism has long been associated with prostate carcinoge
Externí odkaz:
https://doaj.org/article/ba09f1f324f04577a0d88e8b293449cd
Autor:
Blossom Mak, Hui-Ming Lin, Edmond M. Kwan, Heidi Fettke, Ben Tran, Ian D. Davis, Kate Mahon, Martin R. Stockler, Karen Briscoe, Gavin Marx, Alison Zhang, Megan Crumbaker, Winston Tan, Kevin Huynh, Thomas G. Meikle, Natalie A. Mellett, Andrew J. Hoy, Pan Du, Jianjun Yu, Shidong Jia, Anthony M. Joshua, David J. Waugh, Lisa M. Butler, Manish Kohli, Peter J. Meikle, Arun A. Azad, Lisa G. Horvath
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Both changes in circulating lipids represented by a validated poor prognostic 3-lipid signature (3LS) and somatic tumour genetic aberrations are individually associated with worse clinical outcomes in men with metastatic castratio
Externí odkaz:
https://doaj.org/article/0c49ff062a1c4a14adec64ab46d60c0a
Autor:
Ruth Pidsley, Dilys Lam, Wenjia Qu, Timothy J. Peters, Phuc‐Loi Luu, Darren Korbie, Clare Stirzaker, Roger J. Daly, Phillip Stricker, James G. Kench, Lisa G. Horvath, Susan J. Clark
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 10, Pp n/a-n/a (2022)
Abstract Background Prostate cancer is a clinically heterogeneous disease with a subset of patients rapidly progressing to lethal‐metastatic prostate cancer. Current clinicopathological measures are imperfect predictors of disease progression. Epig
Externí odkaz:
https://doaj.org/article/ce0e644fc6654c8a9b89ff431e3a8d9b
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The low efficacy of antipsychotic drugs (e.g., clozapine) for negative symptoms and cognitive impairment has led to the introduction of adjuvant therapies. Because previous data suggest the procognitive potential of the antidiabetic drug met
Externí odkaz:
https://doaj.org/article/2d9dba62c9c244dd8d679eb05da2ea09
Autor:
Mark R. Charbonneau, William S. Denney, Nicholas G. Horvath, Pasquale Cantarella, Mary J. Castillo, Marja K. Puurunen, Aoife M. Brennan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Mark Charbonneau et al. develop a mathematical model that describes the behavior of an engineered bacterial therapeutic, SYNB1618, in the human gastrointestinal tract and its effects on plasma phenylalanine (Phe) levels. This model enables the author
Externí odkaz:
https://doaj.org/article/9c842b6d19dd4ea5ab162237138ababd
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Appendiceal cancer is rare and encompasses a diverse group of tumours ranging from low-grade appendiceal mucinous neoplasms to high-grade adenocarcinomas. Appendiceal cancers often spread to the peritoneal cavity causing extensive mucinous disseminat
Externí odkaz:
https://doaj.org/article/339cfaf4b4e6406384b520232daf470b
Autor:
Ciara Conduit, Blossom Mak, Wenjia Qu, Juliana Di Lulio, Ronan Burder, Matthias Bressel, Thomas Cusick, Haryana M. Dhillon, Richard De Abreu Lourenço, Craig Underhill, Javier Torres, Megan Crumbaker, Florian Honeyball, Anthony Linton, Ray Allen, Ian D. Davis, Susan J. Clark, Lisa G. Horvath, Kate L. Mahon
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Objective: To determine the efficacy and safety of intermittent docetaxel chemotherapy guided by circulating methylated glutathione S-transferase Pi-1 ( mGSTP1 ) in men with metastatic castration-resistant prostate cancer (CRPC). Patients and Methods
Externí odkaz:
https://doaj.org/article/a39320096f8748238086520bc5368c74