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Effect of glutathione depletion on tissue and plasma prostacyclin and thromboxane in rats

Autor: Walter G. Graupner, Philip M. Maynard, Walter Bottje

Publikováno v: Biochemical Pharmacology. 43:1043-1051

Experiments were designed to determine the effects of glutathione (GSH) depletion with L-buthionine sulfoximine (BSO) or diethyl maleate (DEM) on tissue and plasma prostacyclin (6-keto-PGF1 alpha) and thromboxane (TxB2) levels in male Sprague-Dawley

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afc5763c91e82f0f5a0cec46f19667f
https://doi.org/10.1016/0006-2952(92)90611-l

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Indomethacin attenuation of hepatic perfusion and plasma 6-ketoPGF1α elevations following glutathione depletion in rabbits

Autor: Walter Bottje, Raymond Glahn, Hamid Nejad, K.W. Beers, Walter G. Graupner, Kenneth R. Holmes

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1073:168-176

Glutathione (GSH) is important in detoxification and regulating cyclooxygenase activity. Since the liver has high levels of GSH, xenobiotic-induced changes in hepatic GSH could affect hepatic tissue blood perfusion (HP) via alterations in prostagland

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9448d056699eff515a97764922d7a857
https://doi.org/10.1016/0304-4165(91)90198-p

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Nuclear retinoid receptors and their mechanism of action

Autor: M, Pfahl, R, Apfel, I, Bendik, A, Fanjul, G, Graupner, M O, Lee, N, La-Vista, X P, Lu, J, Piedrafita, M A, Ortiz

Publikováno v: Vitamins and hormones. 49

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db05742242b6dfe65a2a8c7e00cd58f0
https://pubmed.ncbi.nlm.nih.gov/7810073

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Prostacyclin elevation following glutathione depletion in vivo. Possible threshold dependency in liver and lung

Autor: W G, Bottje, W G, Graupner, B, Enkvetchakul, K G, Allen

Publikováno v: Biochemical pharmacology. 46(6)

The major objective of this study was to determine if a threshold level of glutathione (GSH) depletion is required to elevate plasma prostacyclin (6-ketoPGF1 alpha) in male Sprague-Dawley rats. Rats were treated i.p. with various doses of phorone, di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2160c39cd07f594bb920dedf19f3c87d
https://pubmed.ncbi.nlm.nih.gov/8216344

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Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation

Autor: H F, Yang-Yen, X K, Zhang, G, Graupner, M, Tzukerman, B, Sakamoto, M, Karin, M, Pfahl

Publikováno v: The New biologist. 3(12)

Retinoids such as retinoic acid (RA) are potent anti-arthritic and anti-neoplastic agents. We investigated the mechanism by which RA inhibits induction of collagenase gene transcription by inflammatory mediators, tumor promoters, and proto-oncogenes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8039ff10df7e30c8d84d3f07d45e2750
https://pubmed.ncbi.nlm.nih.gov/1667479

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Ligand-binding domain of thyroid hormone receptors modulates DNA binding and determines their bifunctional roles

Autor: X K, Zhang, K N, Wills, G, Graupner, M, Tzukerman, T, Hermann, M, Pfahl

Publikováno v: The New biologist. 3(2)

We report here that the thyroid hormone receptors TR alpha and TR beta, and the retinoic acid receptor, RAR, can bind cooperatively to the thyroid hormone response elements (TRE) in both the presence and absence of ligand. Although the transcriptiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ffd29cce000953ea0af418b4eb0c2731
https://pubmed.ncbi.nlm.nih.gov/1648384

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Upregulation of a novel autocrine synthetic pathway for 1,25-dihydroxy-vitamin D3 in intestinal epithelial cells

Autor: G Graupner, D Baylink, M Walter

Publikováno v: Inflammatory Bowel Diseases. 14:S31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d90030791878a5f99b2253f794d9551b
https://doi.org/10.1097/00054725-200812001-00103

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The human estrogen receptor has transcriptional activator and repressor functions in the absence of ligand

Autor: M, Tzukerman, X K, Zhang, T, Hermann, K N, Wills, G, Graupner, M, Pfahl

Publikováno v: The New biologist. 2(7)

Most studies on the cloned human estrogen receptor (hER) have been conducted with a mutant receptor in which Gly400 is changed to Val. Here we describe two novel regulatory functions of wild-type hER that are hormone independent: (i) a constitutive a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::673c6a2a95f54badee506d93ba60c692
https://pubmed.ncbi.nlm.nih.gov/2083252

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