Empagliflozin and left atrial function in patients with type 2 diabetes mellitus and coronary artery disease: insight from the EMPA-HEART CardioLink‐6 randomized clinical trial

Autor: Marina Pourafkari, Kim A. Connelly, Subodh Verma, C. David Mazer, Hwee Teoh, Adrian Quan, Shaun G. Goodman, Archana Rai, Ming Yen Ng, Djeven P. Deva, Piero Triverio, Laura Jiminez-Juan, Andrew T. Yan, Yin Ge

Publikováno v: Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-8 (2024)

Abstract Background Sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated reduction in heart failure outcomes in patients with type 2 diabetes mellitus, although the exact mechanism of benefit remains unclear. Alteration in left atrial

Externí odkaz: https://doaj.org/article/d3c30b4d26cd4335853388ecf7415c6e

Sustained antiviral insulin signaling during West Nile virus infection results in viral mutations

Autor: Aditya B. Char, Chasity E. Trammell, Stephen Fawcett, Manish Chauhan, Yared Debebe, Nora Céspedes, Ryder A. Paslay, Laura R. H. Ahlers, Dharmeshkumar Patel, Shirley Luckhart, Alan G. Goodman

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Arthropod-borne viruses or arboviruses, including West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV) pose significant threats to public health. It is imperative to develop novel methods to control these mosquito-borne viral infections.

Externí odkaz: https://doaj.org/article/ad9e2f9f0b39425d96fca62eb03d92b2

New Anticancer Drugs: Reliably Assessing 'Value' While Addressing High Prices

Autor: David J. Stewart, John-Peter Bradford, Sandeep Sehdev, Tim Ramsay, Vishal Navani, Nigel S. B. Rawson, Di Maria Jiang, Joanna Gotfrit, Paul Wheatley-Price, Geoffrey Liu, Alan Kaplan, Silvana Spadafora, Shaun G. Goodman, Rebecca A. C. Auer, Gerald Batist

Publikováno v: Current Oncology, Vol 31, Iss 5, Pp 2453-2480 (2024)

Countries face challenges in paying for new drugs. High prices are driven in part by exploding drug development costs, which, in turn, are driven by essential but excessive regulation. Burdensome regulation also delays drug development, and this can

Externí odkaz: https://doaj.org/article/e2a0bda42f934ee6ba8bb491b5743aa9

Real-World Risk of Recurrent Cardiovascular Events in Atherosclerotic Cardiovascular Disease Patients with LDL-C Above Guideline-Recommended Threshold: A Retrospective Observational Study

Autor: Erin S. Mackinnon, Lawrence A. Leiter, Rajvi J. Wani, Natasha Burke, Eileen Shaw, Kelcie Witges, Shaun G. Goodman

Publikováno v: Cardiology and Therapy, Vol 13, Iss 1, Pp 205-220 (2024)

Abstract Introduction The 2021 Canadian Cardiovascular Society (CCS) guidelines recommend intensive low-density lipoprotein cholesterol (LDL-C) reduction for patients with atherosclerotic cardiovascular disease (ASCVD). For patients above LDL-C thres

Externí odkaz: https://doaj.org/article/f410e393493f41d99f475ee20cef9c48

Measurements of neutrino oscillation parameters from the T2K experiment using $$3.6\times 10^{21}$$ 3.6 × 10 21 protons on target

Autor: K. Abe, N. Akhlaq, R. Akutsu, A. Ali, S. Alonso Monsalve, C. Alt, C. Andreopoulos, M. Antonova, S. Aoki, T. Arihara, Y. Asada, Y. Ashida, E. T. Atkin, M. Barbi, G. J. Barker, G. Barr, D. Barrow, M. Batkiewicz-Kwasniak, F. Bench, V. Berardi, L. Berns, S. Bhadra, A. Blanchet, A. Blondel, S. Bolognesi, T. Bonus, S. Bordoni, S. B. Boyd, A. Bravar, C. Bronner, S. Bron, A. Bubak, M. Buizza Avanzini, J. A. Caballero, N. F. Calabria, S. Cao, D. Carabadjac, A. J. Carter, S. L. Cartwright, M. G. Catanesi, A. Cervera, J. Chakrani, D. Cherdack, P. S. Chong, G. Christodoulou, A. Chvirova, M. Cicerchia, J. Coleman, G. Collazuol, L. Cook, A. Cudd, C. Dalmazzone, T. Daret, Yu. I. Davydov, A. De Roeck, G. De Rosa, T. Dealtry, C. C. Delogu, C. Densham, A. Dergacheva, F. Di Lodovico, S. Dolan, D. Douqa, T. A. Doyle, O. Drapier, J. Dumarchez, P. Dunne, K. Dygnarowicz, A. Eguchi, S. Emery-Schrenk, G. Erofeev, A. Ershova, G. Eurin, D. Fedorova, S. Fedotov, M. Feltre, A. J. Finch, G. A. Fiorentini Aguirre, G. Fiorillo, M. D. Fitton, J. M. Franco Patiño, M. Friend, Y. Fujii, Y. Fukuda, K. Fusshoeller, L. Giannessi, C. Giganti, V. Glagolev, M. Gonin, J. González Rosa, E. A. G. Goodman, A. Gorin, M. Grassi, M. Guigue, D. R. Hadley, J. T. Haigh, P. Hamacher-Baumann, D. A. Harris, M. Hartz, T. Hasegawa, S. Hassani, N. C. Hastings, Y. Hayato, D. Henaff, A. Hiramoto, M. Hogan, J. Holeczek, A. Holin, T. Holvey, N. T. Hong Van, T. Honjo, F. Iacob, A. K. Ichikawa, M. Ikeda, T. Ishida, M. Ishitsuka, H. T. Israel, K. Iwamoto, A. Izmaylov, N. Izumi, M. Jakkapu, B. Jamieson, S. J. Jenkins, C. Jesús-Valls, J. J. Jiang, P. Jonsson, S. Joshi, C. K. Jung, P. B. Jurj, M. Kabirnezhad, A. C. Kaboth, T. Kajita, H. Kakuno, J. Kameda, S. P. Kasetti, Y. Kataoka, Y. Katayama, T. Katori, M. Kawaue, E. Kearns, M. Khabibullin, A. Khotjantsev, T. Kikawa, H. Kikutani, S. King, V. Kiseeva, J. Kisiel, T. Kobata, H. Kobayashi, T. Kobayashi, L. Koch, S. Kodama, A. Konaka, L. L. Kormos, Y. Koshio, A. Kostin, T. Koto, K. Kowalik, Y. Kudenko, Y. Kudo, S. Kuribayashi, R. Kurjata, T. Kutter, M. Kuze, M. La Commara, L. Labarga, K. Lachner, J. Lagoda, S. M. Lakshmi, M. Lamers James, M. Lamoureux, A. Langella, J.-F. Laporte, D. Last, N. Latham, M. Laveder, L. Lavitola, M. Lawe, Y. Lee, C. Lin, S.-K. Lin, R. P. Litchfield, S. L. Liu, W. Li, A. Longhin, K. R. Long, A. Lopez Moreno, L. Ludovici, X. Lu, T. Lux, L. N. Machado, L. Magaletti, K. Mahn, M. Malek, M. Mandal, S. Manly, A. D. Marino, L. Marti-Magro, D. G. R. Martin, M. Martini, J. F. Martin, T. Maruyama, T. Matsubara, V. Matveev, C. Mauger, K. Mavrokoridis, E. Mazzucato, N. McCauley, J. McElwee, K. S. McFarland, C. McGrew, J. McKean, A. Mefodiev, G. D. Megias, P. Mehta, L. Mellet, C. Metelko, M. Mezzetto, E. Miller, A. Minamino, O. Mineev, S. Mine, M. Miura, L. Molina Bueno, S. Moriyama, P. Morrison, Th. A. Mueller, D. Munford, L. Munteanu, K. Nagai, Y. Nagai, T. Nakadaira, K. Nakagiri, M. Nakahata, Y. Nakajima, A. Nakamura, H. Nakamura, K. Nakamura, K. D. Nakamura, Y. Nakano, S. Nakayama, T. Nakaya, K. Nakayoshi, C. E. R. Naseby, T. V. Ngoc, V. Q. Nguyen, K. Niewczas, S. Nishimori, Y. Nishimura, K. Nishizaki, T. Nosek, F. Nova, P. Novella, J. C. Nugent, H. M. O’Keeffe, L. O’Sullivan, T. Odagawa, T. Ogawa, R. Okada, W. Okinaga, K. Okumura, T. Okusawa, N. Ospina, R. A. Owen, Y. Oyama, V. Palladino, V. Paolone, M. Pari, J. Parlone, S. Parsa, J. Pasternak, M. Pavin, D. Payne, G. C. Penn, D. Pershey, L. Pickering, C. Pidcott, G. Pintaudi, C. Pistillo, B. Popov, K. Porwit, M. Posiadala-Zezula, Y. S. Prabhu, F. Pupilli, B. Quilain, T. Radermacher, E. Radicioni, B. Radics, M. A. Ramírez, P. N. Ratoff, M. Reh, C. Riccio, E. Rondio, S. Roth, N. Roy, A. Rubbia, A. C. Ruggeri, C. A. Ruggles, A. Rychter, K. Sakashita, F. Sánchez, G. Santucci, C. M. Schloesser, K. Scholberg, M. Scott, Y. Seiya, T. Sekiguchi, H. Sekiya, D. Sgalaberna, A. Shaikhiev, F. Shaker, A. Shaykina, M. Shiozawa, W. Shorrock, A. Shvartsman, N. Skrobova, K. Skwarczynski, D. Smyczek, M. Smy, J. T. Sobczyk, H. Sobel, F. J. P. Soler, Y. Sonoda, A. J. Speers, R. Spina, I. A. Suslov, S. Suvorov, A. Suzuki, S. Y. Suzuki, Y. Suzuki, A. A. Sztuc, M. Tada, S. Tairafune, S. Takayasu, A. Takeda, Y. Takeuchi, K. Takifuji, H. K. Tanaka, Y. Tanihara, M. Tani, A. Teklu, V. V. Tereshchenko, N. Teshima, N. Thamm, L. F. Thompson, W. Toki, C. Touramanis, T. Towstego, K. M. Tsui, T. Tsukamoto, M. Tzanov, Y. Uchida, M. Vagins, D. Vargas, M. Varghese, G. Vasseur, C. Vilela, E. Villa, W. G. S. Vinning, U. Virginet, T. Vladisavljevic, T. Wachala, J. G. Walsh, Y. Wang, L. Wan, D. Wark, M. O. Wascko, A. Weber, R. Wendell, M. J. Wilking, C. Wilkinson, J. R. Wilson, K. Wood, C. Wret, J. Xia, Y.-H. Xu, K. Yamamoto, T. Yamamoto, C. Yanagisawa, G. Yang, T. Yano, K. Yasutome, N. Yershov, U. Yevarouskaya, M. Yokoyama, Y. Yoshimoto, N. Yoshimura, M. Yu, R. Zaki, A. Zalewska, J. Zalipska, K. Zaremba, G. Zarnecki, X. Zhao, T. Zhu, M. Ziembicki, E. D. Zimmerman, M. Zito, S. Zsoldos, T2K Collaboration

Publikováno v: European Physical Journal C: Particles and Fields, Vol 83, Iss 9, Pp 1-50 (2023)

Abstract The T2K experiment presents new measurements of neutrino oscillation parameters using $$19.7(16.3)\times 10^{20}$$ 19.7 ( 16.3 ) × 10 20 protons on target (POT) in (anti-)neutrino mode at the far detector (FD). Compared to the previous anal

Externí odkaz: https://doaj.org/article/428d75b4ee154491b751f844ef2d191d