Zobrazeno 1 - 10
of 980
pro vyhledávání: '"G, Gerhart"'
Autor:
Jacqueline G. Gerhart, Fernando O. Carreño, Jennifer L. Ford, Andrea N. Edginton, Eliana M. Perrin, Kevin M. Watt, William J. Muller, Andrew M. Atz, Amira Al‐Uzri, Paula Delmore, Daniel Gonzalez, Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 778-791 (2022)
Abstract Obesity is an increasingly alarming public health threat, with nearly 20% of children classified as obese in the United States today. Children with obesity are commonly prescribed the opioids fentanyl and methadone, and accurate dosing is cr
Externí odkaz:
https://doaj.org/article/dd4ab2e51fa44b86a239b72f4ea91718
Autor:
Jacqueline G. Gerhart, Stephen Balevic, Jaydeep Sinha, Eliana M. Perrin, Jian Wang, Andrea N. Edginton, Daniel Gonzalez
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Childhood obesity is an alarming public health problem. The pediatric obesity rate has quadrupled in the past 30 years, and currently nearly 20% of United States children and 9% of children worldwide are classified as obese. Drug distribution and eli
Externí odkaz:
https://doaj.org/article/7a90c9cc0656433783c0cb0ed53e8d77
Autor:
Jacqueline G. Gerhart, Kevin M. Watt, Andrea Edginton, Kelly C. Wade, Sara N. Salerno, Daniel K. Benjamin Jr, P. Brian Smith, Christoph P. Hornik, Michael Cohen‐Wolkowiez, Shahnaz Duara, Ashley Ross, Karen Shattuck, Dan L. Stewart, Natalie Neu, Daniel Gonzalez, the Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 7, Pp 500-510 (2019)
Fluconazole is used to treat hematogenous Candida meningoencephalitis in preterm and term infants. To characterize plasma and central nervous system exposure, an adult fluconazole physiologically‐based pharmacokinetic (PBPK) model was scaled to inf
Externí odkaz:
https://doaj.org/article/7d2b1a51f05e4740a751175400d3d625
Autor:
Jacqueline G, Gerhart, Fernando O, Carreño, Matthew Shane, Loop, Craig R, Lee, Andrea N, Edginton, Jaydeep, Sinha, Karan R, Kumar, Carl M, Kirkpatrick, Christoph P, Hornik, Daniel, Gonzalez, Don, Stone
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:391-403
Dosing guidance for children with obesity is often unknown despite the fact that nearly 20% of US children are classified as obese. Enoxaparin, a commonly prescribed low-molecular-weight heparin, is dosed based on body weight irrespective of obesity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d7c22c6fcc68a82b4651b610843390
https://doi.org/10.1002/cpt.2618
https://doi.org/10.1002/cpt.2618
Autor:
Daniel Gonzalez, Michael Cohen-Wolkowiez, Karan R. Kumar, Fernando O. Carreño, Andrea N. Edginton, Vincent Harris, Jaydeep Sinha, Christoph P. Hornik, Aruna Rikhi, Eliana M. Perrin, Samit Ganguly, Jacqueline G Gerhart
Publikováno v:
Clinical Pharmacokinetics. 61:307-320
While one in five children in the USA are now obese, and more than three-quarters receive at least one drug during childhood, there is limited dosing guidance for this vulnerable patient population. Physiologically based pharmacokinetic modeling can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e2e7ccb3bcc9934e863ff2d0a1a42c
https://doi.org/10.1007/s40262-021-01072-4
https://doi.org/10.1007/s40262-021-01072-4
Autor:
Rachel G. Greenberg, Andrea N. Edginton, Michael Cohen-Wolkowiez, Daniel Gonzalez, Samit Ganguly, Jacqueline G Gerhart
Publikováno v:
Clin Pharmacokinet
BACKGROUND: Meropenem is a broad-spectrum carbapenem antibiotic approved by the U.S. Food and Drug Administration for use in pediatric patients, including treating complicated intra-abdominal infections (cIAIs) in infants < 3 months of age. The impac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a56638899f9d5fa78cacd4dc946f180
https://doi.org/10.1007/s40262-021-01046-6
https://doi.org/10.1007/s40262-021-01046-6
Autor:
Sara N. Salerno, Edmund V. Capparelli, Helen McIlleron, Jacqueline G. Gerhart, Julie B. Dumond, Angela D. M. Kashuba, Paolo Denti, Daniel Gonzalez
Publikováno v:
Pharmacotherapy.
Treatment of HIV and tuberculosis co-infection leads to significant mortality in pediatric patients, and treatment can be challenging due to the clinically significant drug-drug interaction (DDI) between lopinavir/ritonavir (LPV/RTV) and rifampin. Do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef35ec160d5bff4d22480262bb8481ca
https://pubmed.ncbi.nlm.nih.gov/35607886
https://pubmed.ncbi.nlm.nih.gov/35607886
Autor:
Anastasia S, Lambrou, Philip, Shirk, Molly K, Steele, Prabasaj, Paul, Clinton R, Paden, Betsy, Cadwell, Heather E, Reese, Yutaka, Aoki, Norman, Hassell, Xiao-Yu, Zheng, Sarah, Talarico, Jessica C, Chen, M Steven, Oberste, Dhwani, Batra, Laura K, McMullan, Alison Laufer, Halpin, Summer E, Galloway, Duncan R, MacCannell, Rebecca, Kondor, John, Barnes, Adam, MacNeil, Benjamin J, Silk, Vivien G, Dugan, Heather M, Scobie, David E, Wentworth, Jason, Caravas, Nicholas A, Kovacs, Jonathan G, Gerhart, Han, Jia Ng, Andrew, Beck, Reina, Chau, Roxana, Cintron, Peter W, Cook, Christopher A, Gulvik, Dakota, Howard, Yunho, Jang, Kristen, Knipe, Kristine A, Lacek, Kara A, Moser, Adrian C, Paskey, Benjamin L, Rambo-Martin, Roopa R, Nagilla, Adam C, Retchless, Matthew W, Schmerer, Sandra, Seby, Samuel S, Shepard, Richard A, Stanton, Thomas J, Stark, Anna, Uehara, Yvette, Unoarumhi, Meghan L, Bentz, Alex, Burgin, Mark, Burroughs, Morgan L, Davis, Matthew W, Keller, Lisa M, Keong, Shoshona S, Le, Justin S, Lee, Joseph C, Madden Jr, Sarah, Nobles, D. Collins, Owuor, Jasmine, Padilla, Mili, Sheth, Malania M, Wilson
Publikováno v:
MMWR. Morbidity and mortality weekly report. 71(6)
Genomic surveillance is a critical tool for tracking emerging variants of SARS-CoV-2 (the virus that causes COVID-19), which can exhibit characteristics that potentially affect public health and clinical interventions, including increased transmissib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e98fdb104aa9c7a286ea2815e2553dc
https://pubmed.ncbi.nlm.nih.gov/35389973
https://pubmed.ncbi.nlm.nih.gov/35389973
Physiologically Based Pharmacokinetic Modeling of Metformin in Children and Adolescents With Obesity
Autor:
Jennifer Lynn Ford, Jacqueline G. Gerhart, Andrea N. Edginton, Jack A. Yanovski, Yuen Yi Hon, Daniel Gonzalez
Publikováno v:
Journal of clinical pharmacology. 62(8)
Childhood obesity continues to rise in the United States and, with it, the off-label use of metformin for weight loss. The influence of age and obesity on the drug's disposition and exposure has not previously been studied using a mechanistic framewo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237a0f391ec4efc631dda54662fa66e9
https://pubmed.ncbi.nlm.nih.gov/35119103
https://pubmed.ncbi.nlm.nih.gov/35119103
Autor:
Daniel Gonzalez, Christoph P. Hornik, Yi Shuan S Wu, Michael Cohen-Wolkowiez, Julie Autmizguine, Jacqueline G Gerhart, Marjan Cobbaert
Publikováno v:
Antimicrob Agents Chemother
The antibiotic combination trimethoprim (TMP)-sulfamethoxazole (SMX) has a broad spectrum of activity and is used for the treatment of numerous infections, but pediatric pharmacokinetic (PK) data are limited. We previously published population PK (po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffe8f335a697d0765cccf9df8ec3308
https://doi.org/10.1128/aac.02149-20
https://doi.org/10.1128/aac.02149-20