Zobrazeno 1 - 10
of 191
pro vyhledávání: '"G, Gekker"'
Publikováno v:
The Journal of Immunology. 158:2449-2455
An understanding of how viral replication in glial cells responds to proinflammatory cytokines is important in delineating HIV-1 neuropathogenesis. Because no information is available in the literature regarding the regulatory effects of exogenous cy
Autor:
N Balantac, A H Kaplan, Stuart L. Bursten, C Tompkins, David W. Leung, P K Peterson, R Weeks, G Gekker, Chun C. Chao, G E Underiner
Publikováno v:
Proceedings of the National Academy of Sciences. 92:4813-4817
Viruses such as human immunodeficiency virus (HIV) require cellular activation for expression. Cellular activation in lymphoid cells is associated with augmented accumulation of certain phosphatidic acid (PA) species derived from the hydrolysis of gl
Publikováno v:
The Journal of Immunology. 152:1246-1252
Microglia may play an important role in host defense of the central nervous system against Toxoplasma gondii, and cytokines produced by these glial cells may participate in their antitoxoplasma activity. In our study, the antitoxoplasma activity of h
Publikováno v:
The Journal of Immunology. 150:3404-3410
Microglia may play a role in host defense against Toxoplasma gondii in the central nervous system. In our study, the antitoxoplasma activity of murine microglia was investigated. T. gondii multiplied readily in cultured microglial cells, and activati
Publikováno v:
The Journal of Immunology. 149:676-680
Cocaine and CMV each have been suggested to promote the progression of HIV-1 infection. In the present study, the interaction of cocaine and CMV was investigated in a PBMC coculture assay in which release of HIV-1 p24 Ag into coculture supernatants w
Publikováno v:
The Journal of Immunology. 146:81-84
Cocaine use is an important high risk behavior in the AIDS epidemic. In this study, we tested the hypothesis that cocaine potentiates the replication of HIV-1 in human PBMC. A coculture system was used in which PBMC from healthy donors were incubated
Publikováno v:
Advances in experimental medicine and biology. 493
Publikováno v:
Journal of human virology. 2(2)
To characterize replication patterns and cytopathic effects during human cytomegalovirus (HCMV) infection of brain cells.Primary human mixed glial/neuronal cells, as well as purified microglial, astroglial, and enriched neuronal cell cultures, were i
Publikováno v:
Advances in experimental medicine and biology. 437
We found that orphan opioid receptor (OR) mRNA was constitutively expressed in human fetal microglia, astrocytes, and cerebral cortical neurons. An OR antisense oligonucleotide markedly inhibited HIV-1 expression in enriched microglial cell and the m
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
Opiates modulate many macrophage functions. Microglia, the resident macrophages of the brain, migrate to sites of inflammation within the CNS. Using primer sets designed to span the entire open reading frame of the human brain mu opioid receptor (MOR