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Loss of cell surface TFII-I promotes apoptosis in prostate cancer cells stimulated with activated α₂ -macroglobulin

Autor: U K, Misra, Y M, Mowery, G, Gawdi, S V, Pizzo

Publikováno v: Journal of cellular biochemistry. 112(6)

Receptor-recognized forms of α₂ -macroglobulin (α₂ M) bind to cell surface-associated GRP78 and initiate pro-proliferative and anti-apoptotic signaling. Ligation of GRP78 with α₂ M also upregulates TFII-I, which binds to the GRP78 promoter a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::382ce3747dfa091eefa6a988c1d62b67
https://pubmed.ncbi.nlm.nih.gov/21503958

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Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages

Autor: U K, Misra, C L, Adlakha, G, Gawdi, M K, McMillian, S V, Pizzo, D T, Laskowitz

Publikováno v: Journal of leukocyte biology. 70(4)

Apolipoprotein E (ApoE) is a 34-kDa cholesterol transport protein that also possesses immunomodulatory properties. In this study, we demonstrate that ApoE initiates a signaling cascade in murine peritoneal macrophages that leads to increased producti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ac752a393e6f465437cf50cb052c1cf
https://pubmed.ncbi.nlm.nih.gov/11590206

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Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells

Autor: M, Gonzalez-Gronow, H E, Grenett, M R, Weber, G, Gawdi, S V, Pizzo

Publikováno v: The Biochemical journal. 355(Pt 2)

Both plasminogen (Pg) activation and matrix metalloproteinases (MMPs) are involved in the proteolytic degradation of extracellular matrix components, a requisite event for malignant cell metastasis. The highly invasive 1-LN human prostate tumour cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95f9dd02af294fc30ddf7974dfebca7b
https://pubmed.ncbi.nlm.nih.gov/11284727

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Cyclosporin A inhibits inositol 1,4,5-trisphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages

Autor: U K, Misra, G, Gawdi, S V, Pizzo

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(11)

We have studied the effects of the immunosuppressive drug cyclosporin A (CsA) on the generation of inositol 1,4,5-trisphosphate (IP3) and intracellular Ca2+ levels elicited upon ligation of murine macrophage receptors for alpha2-macroglobulin, bradyk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e85c5ab1ca4f20870edcffd0b151b547
https://pubmed.ncbi.nlm.nih.gov/9834096

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Chloroquine, quinine and quinidine inhibit calcium release from macrophage intracellular stores by blocking inositol 1,4,5-trisphosphate binding to its receptor

Autor: U K, Misra, G, Gawdi, S V, Pizzo

Publikováno v: Journal of cellular biochemistry. 64(2)

The binding of many ligands to cellular receptors induces a signaling cascade which generates inositol 1,4,5-trisphosphate (IP3). IP3 binding to its receptors in various internal compartments causes a rapid Ca2+ efflux into the cytosol. We now demons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30a33e08118193f3773466bd7939068f
https://pubmed.ncbi.nlm.nih.gov/9027583

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Binding of rat alpha 1-inhibitor-3-methylamine to the alpha 2-macroglobulin signaling receptor induces second messengers

Autor: U K, Misra, G, Gawdi, S V, Pizzo

Publikováno v: Journal of cellular biochemistry. 61(1)

Binding of receptor-recognized forms of tetrameric human alpha 2-macroglobulin (alpha 2M*) to a macrophage signaling receptor induces cAMP synthesis, increases in inositol 1,4,5-triphosphate (IP3) synthesis, and a concomitant rise in cytosolic free c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38ee7120448d605771e72ba8fb1cab7b
https://pubmed.ncbi.nlm.nih.gov/8726356

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Evidence for a second alpha 2-macroglobulin receptor

Autor: U K, Misra, C T, Chu, G, Gawdi, S V, Pizzo

Publikováno v: The Journal of biological chemistry. 269(17)

alpha 2-Macroglobulin (alpha 2M)-methylamine binds to purified low density lipoprotein receptor-related protein (LRP), and it is assumed that LRP functions as the alpha 2M receptor in vivo. Binding of alpha 2M-methylamine to macrophage receptors elev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e481c5fa4a7dd9691178a16349bb60c
https://pubmed.ncbi.nlm.nih.gov/7513689

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Role of Na+/H+ exchange by interferon-gamma in enhanced expression of JE and I-A beta genes

Autor: V, Prpic, S F, Yu, F, Figueiredo, P W, Hollenbach, G, Gawdi, B, Herman, R J, Uhing, D O, Adams

Publikováno v: Science (New York, N.Y.). 244(4903)

The rapid transductional sequences initiated by interferon-gamma (IFN-gamma) on binding to its receptor regulate functional and genomic responses in many cells but are not well defined. Induction of macrophage activation is an example of such functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13220568387f8ae39ea104621fa9ae66
https://pubmed.ncbi.nlm.nih.gov/2541500

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