Zobrazeno 1 - 10
of 499
pro vyhledávání: '"G, Fishwick"'
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 261 (2023)
Increases in antibiotic usage and antimicrobial resistance occurrence have caused a dramatic reduction in the effectiveness of many frontline antimicrobial treatments. Topoisomerase inhibitors including fluoroquinolones are broad-spectrum antibiotics
Externí odkaz:
https://doaj.org/article/6a1c882b99af4b1894a0f881f858331d
Autor:
Martin J. McPhillie, Ying Zhou, Mark R. Hickman, James A. Gordon, Christopher R. Weber, Qigui Li, Patty J. Lee, Kangsa Amporndanai, Rachel M. Johnson, Heather Darby, Stuart Woods, Zhu-hong Li, Richard S. Priestley, Kurt D. Ristroph, Scott B. Biering, Kamal El Bissati, Seungmin Hwang, Farida Esaa Hakim, Sarah M. Dovgin, Joseph D. Lykins, Lucy Roberts, Kerrie Hargrave, Hua Cong, Anthony P. Sinai, Stephen P. Muench, Jitender P. Dubey, Robert K. Prud'homme, Hernan A. Lorenzi, Giancarlo A. Biagini, Silvia N. Moreno, Craig W. Roberts, Svetlana V. Antonyuk, Colin W. G. Fishwick, Rima McLeod
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to impro
Externí odkaz:
https://doaj.org/article/2c4f99fc24ed49b8a965b629b176459d
Autor:
Kangsa Amporndanai, Rachel M. Johnson, Paul M. O'Neill, Colin W. G. Fishwick, Alexander H. Jamson, Shaun Rawson, Stephen P. Muench, S. Samar Hasnain, Svetlana V. Antonyuk
Publikováno v:
IUCrJ, Vol 5, Iss 2, Pp 200-210 (2018)
Cytochrome bc1, a dimeric multi-subunit electron-transport protein embedded in the inner mitochondrial membrane, is a major drug target for the treatment and prevention of malaria and toxoplasmosis. Structural studies of cytochrome bc1 from mammalian
Externí odkaz:
https://doaj.org/article/a9927769951f4f6387d594d9fbff2534
Autor:
Sarah Batson, Cesira de Chiara, Vita Majce, Adrian J. Lloyd, Stanislav Gobec, Dean Rea, Vilmos Fülöp, Christopher W. Thoroughgood, Katie J. Simmons, Christopher G. Dowson, Colin W. G. Fishwick, Luiz Pedro S. de Carvalho, David I. Roper
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
The antibiotic D-cycloserine (DCS) targets the peptidoglycan biosynthesis enzyme D-Ala-D-Ala ligase (Ddl). Here the authors reveal the DCS inhibitory mechanism by determining the structure of E. coli DdlB with a phosphorylated DCS molecule in the act
Externí odkaz:
https://doaj.org/article/66e59bce52674d29b83d6b33b62cc099
Autor:
Jürgen Brem, Ricky Cain, Samuel Cahill, Michael A. McDonough, Ian J. Clifton, Juan-Carlos Jiménez-Castellanos, Matthew B. Avison, James Spencer, Colin W. G. Fishwick, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Bacterial beta-lactamases are responsible for resistance to beta-lactams, the most important family of antibiotics. Here, the authors reveal cyclic boronate inhibitors that are active against both serine- and metallo-beta-lactamases and represent a p
Externí odkaz:
https://doaj.org/article/bb894e352b404c67a6c95bd78e1a12a8
Autor:
Pauline A. Lang, Anete Parkova, Thomas M. Leissing, Karina Calvopiña, Ricky Cain, Alen Krajnc, Tharindi D. Panduwawala, Jules Philippe, Colin W. G. Fishwick, Peteris Trapencieris, Malcolm G. P. Page, Christopher J. Schofield, Jürgen Brem
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 899 (2020)
Resistance to β-lactam antibacterials, importantly via production of β-lactamases, threatens their widespread use. Bicyclic boronates show promise as clinically useful, dual-action inhibitors of both serine- (SBL) and metallo- (MBL) β-lactamases.
Externí odkaz:
https://doaj.org/article/6ecf02233cc14718992028bf8aa429eb
Autor:
Joseph D. Lykins, Ekaterina V. Filippova, Andrei S. Halavaty, George Minasov, Ying Zhou, Ievgeniia Dubrovska, Kristin J. Flores, Ludmilla A. Shuvalova, Jiapeng Ruan, Kamal El Bissati, Sarah Dovgin, Craig W. Roberts, Stuart Woods, Jon D. Moulton, Hong Moulton, Martin J. McPhillie, Stephen P. Muench, Colin W. G. Fishwick, Elisabetta Sabini, Dhanasekaran Shanmugam, David S. Roos, Rima McLeod, Wayne F. Anderson, Huân M. Ngô
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Toxoplasma gondii, an Apicomplexan parasite, causes significant morbidity and mortality, including severe disease in immunocompromised hosts and devastating congenital disease, with no effective treatment for the bradyzoite stage. To address this, we
Externí odkaz:
https://doaj.org/article/7419bf5aa70142e9901dc7a9d33f4a08
Autor:
Kyle M. Orritt, Lipeng Feng, Juliette F. Newell, Jack N. Sutton, Scott Grossman, Thomas Germe, Lauren R. Abbott, Holly L. Jackson, Benjamin K. L. Bury, Anthony Maxwell, Martin J. McPhillie, Colin W. G. Fishwick
Publikováno v:
RSC Medicinal Chemistry. 13:831-839
A computational design, make and test strategy was used to identify antibacterial inhibitors of bacterial DNA gyrase and topoisomerase IV, proposed to bind at a novel allosteric site.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::519fd7fc93ae6a9798c16c90eec91cb2
https://doi.org/10.1039/d2md00049k
https://doi.org/10.1039/d2md00049k
Autor:
Niklas G. Johansson, Evgeni Grazhdankin, Loic Dreano, Ayman Khattab, Colin W. G. Fishwick, Ainoleena Turku, Alexandros Kiriazis, Jari Yli-Kauhaluoma, Henri Xhaard, Daniel Ayuso Pérez, Adrian Goldman, Gustav Boije af Gennäs, Aaron Wilkinson, Yuezhou Zhang, Keni Vidilaseris, Matti Tamminen, Seppo Meri
Publikováno v:
ACS Medicinal Chemistry Letters
Membrane-bound pyrophosphatases (mPPases) regulate energy homeostasis in pathogenic protozoan parasites and lack human homologues, which makes them promising targets in e.g. malaria. Yet only few nonphosphorus inhibitors have been reported so far. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfaec4e239aee10ccef50dda17fbbbe8
https://doi.org/10.1021/acsmedchemlett.9b00537
https://doi.org/10.1021/acsmedchemlett.9b00537
Autor:
Jeffrey M Haynes, Robert G Fishwick
Publikováno v:
Respiratory care. 67(4)
Blood gas quality control (QC) is an essential and mandatory part of a laboratory's quality plan. The acceptable QC range should be 2 SD from the mean value. The use of assayed QC material does not negate the responsibility of the laboratory to calcu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7751f42f47d08fb3e06231a4208fb09
https://pubmed.ncbi.nlm.nih.gov/35078931
https://pubmed.ncbi.nlm.nih.gov/35078931