Zobrazeno 1 - 10
of 1 196
pro vyhledávání: '"G, Filler"'
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT Major Candida albicans virulence traits include its ability to make hyphae, to produce a biofilm, and to damage host cells. These traits depend upon expression of hypha-associated genes. A gene expression comparison among clinical isolates s
Externí odkaz:
https://doaj.org/article/b6d8c4296bb54647b0a76ae8ea87f97f
Autor:
Tingting Zhou, Norma V. Solis, Michaela Marshall, Qing Yao, Rachel Garleb, Mengli Yang, Eric Pearlman, Scott G. Filler, Haoping Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Patients with decreased levels of CD18 (β2 integrins) suffer from life-threatening bacterial and fungal infections. CD11b, the α subunit of integrin CR3 (CD11b/CD18, αMβ2), is essential for mice to fight against systemic Candida albicans
Externí odkaz:
https://doaj.org/article/0f81f176012742c69ace6098249d696b
Autor:
Xin Zhou, Audrey Hilk, Norma V Solis, Nivea Pereira De Sa, Bode M Hogan, Tessa A Bierbaum, Maurizio Del Poeta, Scott G Filler, Laura S Burrack, Anna Selmecki
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012389 (2024)
Ergosterol is essential for fungal cell membrane integrity and growth, and numerous antifungal drugs target ergosterol. Inactivation or modification of ergosterol biosynthetic genes can lead to changes in antifungal drug susceptibility, filamentation
Externí odkaz:
https://doaj.org/article/74e7071a7fd741f9867c94874908f19c
Autor:
Rajesh Parmar, Harry Pickering, Richard Ahn, Maura Rossetti, David W. Gjertson, Felicia Ruffin, Liana C. Chan, Vance G. Fowler, Michael R. Yeaman, Elaine F. Reed, MRSA Systems Immunology Group, Arnold S. Bayer, Yu-Ling Chang, Scott G. Filler, Vance G. Fowler Jr., David Gjertson, Alexander Hoffmann, Felix Mba Medie, Tsuyoshi Mikkaichi, Simon Mitchell, Yan Qin, Batu K. Sharma-Kuinkel, Katherine Sheu, Joshua Thaden, Alan J. Waring, Yan Q. Xiong, Ying Zheng, Michael R. Yeaman.
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionStaphylococcus aureus bacteremia (SAB) is a life-threatening infection particularly involving methicillin-resistant S. aureus (MRSA). In contrast to resolving MRSA bacteremia (RB), persistent MRSA bacteremia (PB) blood cultures remain pos
Externí odkaz:
https://doaj.org/article/a79666f3f3d748269414ccca0d43d820
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 11 (2024)
Background: Zinc status, its role in bone metabolism and efficacy of deficiency correction has not been well studied in children with chronic kidney disease (CKD). Objectives: The primary objective was to investigate whether 3 months of oral zinc sup
Externí odkaz:
https://doaj.org/article/60c69e2b39d84a58b79139021f4bb137
Autor:
Virginia E. Glazier, Juraj Kramara, Tomye Ollinger, Norma V. Solis, Robert Zarnowski, Rohan S. Wakade, Min-Ju Kim, Gabriel J. Weigel, Shen-Huan Liang, Richard J. Bennett, Melanie Wellington, David R. Andes, Mark A. Stamnes, Scott G. Filler, Damian J. Krysan
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Candida albicans is a diploid human fungal pathogen that displays significant genomic and phenotypic heterogeneity over a range of virulence traits and in the context of a variety of environmental niches. Here, we show that the effect of Rob
Externí odkaz:
https://doaj.org/article/d9d88ba2cedc4442aa5ec5ea0648059b
Autor:
Zhangyu Cheng, Caroline Stefani, Thomas Skillman, Aleksandra Klimas, Aramchan Lee, Emma F. DiBernardo, Karina Mueller Brown, Tatyana Milman, Yuhong Wang, Brendan R. Gallagher, Katherine Lagree, Bhanu P. Jena, Jose S. Pulido, Scott G. Filler, Aaron P. Mitchell, N. Luisa Hiller, Adam Lacy‐Hulbert, Yongxin Zhao
Publikováno v:
Advanced Science, Vol 10, Iss 30, Pp n/a-n/a (2023)
Abstract Super‐resolution optical imaging tools are crucial in microbiology to understand the complex structures and behavior of microorganisms such as bacteria, fungi, and viruses. However, the capabilities of these tools, particularly when it com
Externí odkaz:
https://doaj.org/article/f62ce5c239f04a70b2f59e74b0c6f6b3
Autor:
Hong Liu, Jianfeng Lin, Quynh T. Phan, Fabrice N. Gravelat, Donald C. Sheppard, Scott G. Filler
Publikováno v:
mSphere, Vol 8, Iss 5 (2023)
ABSTRACT During the initiation of invasive aspergillosis, inhaled Aspergillus fumigatus conidia are deposited on the epithelial cells lining the bronchi, terminal bronchioles, and alveoli. While the interactions of A. fumigatus with bronchial and typ
Externí odkaz:
https://doaj.org/article/ec3c38c7baaa4fb9b276cb2d53534c77
Autor:
Quynh T Phan, Norma V Solis, Max V Cravener, Marc Swidergall, Jianfeng Lin, Manning Y Huang, Hong Liu, Shakti Singh, Ashraf S Ibrahim, Massimiliano Mazzone, Aaron P Mitchell, Scott G Filler
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011579 (2023)
Fungal invasion of the oral epithelium is central to the pathogenesis of oropharyngeal candidiasis (OPC). Candida albicans invades the oral epithelium by receptor-induced endocytosis but this process is incompletely understood. We found that C. albic
Externí odkaz:
https://doaj.org/article/e8148324a566459f8f1ffa7fd287ef45
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Invasive aspergillosis is initiated when Aspergillus fumigatus adheres to and invades the pulmonary epithelial cells that line the airways and alveoli. To gain deeper insight into how pulmonary epithelial cells respond to A. fumigatus invasi
Externí odkaz:
https://doaj.org/article/174ba912379d47f2b76101e0e36c1c74