Zobrazeno 1 - 10
of 379
pro vyhledávání: '"G, Fairbrother"'
Autor:
Luke Buerer, Nathaniel E. Clark, Anastasia Welch, Chaorui Duan, Allison J. Taggart, Brittany A. Townley, Jing Wang, Rachel Soemedi, Stephen Rong, Chien-Ling Lin, Yi Zeng, Adam Katolik, Jonathan P. Staley, Masad J. Damha, Nima Mosammaparast, William G. Fairbrother
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The majority of genic transcription is intronic. Introns are removed by splicing as branched lariat RNAs which require rapid recycling. The branch site is recognized during splicing catalysis and later debranched by Dbr1 in the rate-limiting
Externí odkaz:
https://doaj.org/article/81ba1794519b409e80b2dd49a5ba6bff
Autor:
Chaorui Duan, Truman Mooney, Luke Buerer, Cory Bowers, Stephen Rong, Seong Won Kim, Alger M. Fredericks, Sean F. Monaghan, William G. Fairbrother
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background The removal of introns occurs through the splicing of a 5′ splice site (5′ss) with a 3′ splice site (3′ss). These two elements are recognized by distinct components of the spliceosome. However, introns in higher eukaryotes
Externí odkaz:
https://doaj.org/article/6f2d53f327de41ca8b4d2eea6922bcd8
Autor:
Alger M. Fredericks, Maximilian S. Jentzsch, William G. Cioffi, Maya Cohen, William G. Fairbrother, Shivam J. Gandhi, Elizabeth O. Harrington, Gerard J. Nau, Jonathan S. Reichner, Corey E. Ventetuolo, Mitchell M. Levy, Alfred Ayala, Sean F. Monaghan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract COVID-19 has impacted millions of patients across the world. Molecular testing occurring now identifies the presence of the virus at the sampling site: nasopharynx, nares, or oral cavity. RNA sequencing has the potential to establish both th
Externí odkaz:
https://doaj.org/article/1ccc936206f04b79ba48126968de0b36
Autor:
Alger M. Fredericks, Kyle W. East, Yuanjun Shi, Jinchan Liu, Federica Maschietto, Alfred Ayala, William G. Cioffi, Maya Cohen, William G. Fairbrother, Craig T. Lefort, Gerard J. Nau, Mitchell M. Levy, Jimin Wang, Victor S. Batista, George P. Lisi, Sean F. Monaghan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continue to cause disease and impair the effectiveness of treatments. The therapeutic potential of convergent neutralizing antibodies (NAbs) from fully recovered patients has be
Externí odkaz:
https://doaj.org/article/4d572fd4d5154c16ba5a156cd43dae53
Autor:
Zishan Wang, Xiao Fan, Yufeng Shen, Meghana S Pagadala, Rebecca Signer, Kamil J. Cygan, William G. Fairbrother, Hannah Carter, Wendy K. Chung, Kuan-lin Huang
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background DNA sequencing is increasingly incorporated into the routine care of cancer patients, many of whom also carry inherited, moderate/high-penetrance variants associated with other diseases. Yet, the prevalence and consequence of such
Externí odkaz:
https://doaj.org/article/905f7660e8e9495384ed1ade4ae672f5
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Splicing-disrupting mutations are linked to diseases. By employing a machine learning approach, the authors show that certain exons, termed hotspot exons, are enriched for splicing-disruption variants and susceptible to splicing perturbations.
Externí odkaz:
https://doaj.org/article/504d517c7c5c44f5a7cb252a1c59d126
Autor:
Stephen Rong, Luke Buerer, Christy L. Rhine, Jing Wang, Kamil J. Cygan, William G. Fairbrother
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Splicing is regulated by cis-acting elements in pre-mRNAs such as exonic or intronic splicing enhancers and silencers. Here the authors show that exonic splicing enhancers are enriched in exons compared to introns due to mutational bias coupled with
Externí odkaz:
https://doaj.org/article/3443e38d261c49c28705c2a31a32ed6b
Autor:
Christy L. Rhine, Christopher Neil, Jing Wang, Samantha Maguire, Luke Buerer, Mitchell Salomon, Ijeoma C. Meremikwu, Juliana Kim, Natasha T. Strande, William G. Fairbrother
Publikováno v:
PLoS Genetics, Vol 18, Iss 1 (2022)
To determine the contribution of defective splicing in Autism Spectrum Disorders (ASD), the most common neurodevelopmental disorder, a high throughput Massively Parallel Splicing Assay (MaPSY) was employed and identified 42 exonic splicing mutants ou
Externí odkaz:
https://doaj.org/article/069993f0195f4208a8771077c69659a7
Autor:
Jun Cheng, Thi Yen Duong Nguyen, Kamil J. Cygan, Muhammed Hasan Çelik, William G. Fairbrother, žiga Avsec, Julien Gagneur
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Predicting the effects of genetic variants on splicing is highly relevant for human genetics. We describe the framework MMSplice (modular modeling of splicing) with which we built the winning model of the CAGI5 exon skipping prediction chall
Externí odkaz:
https://doaj.org/article/00725e339fa84734b0b17a4ab4e0dc83
Autor:
Sean F. Monaghan, Debasree Banerjee, Chun-Shiang Chung, Joanne Lomas-Neira, Kamil J. Cygan, Christy L. Rhine, William G. Fairbrother, Daithi S. Heffernan, Mitchell M. Levy, William G. Cioffi, Alfred Ayala
Publikováno v:
Molecular Medicine, Vol 24, Iss 1, Pp 1-7 (2018)
Abstract Background Critically ill patients with sepsis and acute respiratory distress syndrome have severely altered physiology and immune system modifications. RNA splicing is a basic molecular mechanism influenced by physiologic alterations. Immun
Externí odkaz:
https://doaj.org/article/1583a1b9704443dcbf661badd740175e