Zobrazeno 1 - 10
of 146
pro vyhledávání: '"G, Ehrhardt"'
Publikováno v:
Bioinformatics and Biology Insights, Vol 13 (2019)
Advancements in flow cytometers with capability to measure 15 or more parameters have enabled us to characterize cell populations at unprecedented levels of detail. Beyond discovery research, there is now a growing demand to dive deeper into evaluati
Externí odkaz:
https://doaj.org/article/16bf19fccf044922b9d0e31e4fad5794
Autor:
Filipe B, Rodrigues, Gail, Owen, Swati, Sathe, Elena, Pak, Dipinder, Kaur, Anka G, Ehrhardt, Sherry, Lifer, Jenny, Townhill, Katarzyna, Schubert, Blair R, Leavitt, Mark, Guttman, Jee, Bang, Jan, Lewerenz, Jamie, Levey, Cristina, Sampaio, Edward J, Wild
Publikováno v:
Journal of Huntington's Disease. 11:59-69
Background: Biomarkers are needed to monitor disease progression, target engagement and efficacy in Huntington’s disease (HD). Cerebrospinal fluid (CSF) is an ideal medium to research such biomarkers due to its proximity to the brain. Objective: To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c926237ce568644fd650bc002d29c5a
https://doi.org/10.3233/jhd-210508
https://doi.org/10.3233/jhd-210508
Autor:
Christopher Medway, Vanessa C. Wheeler, Diane Lucente, Amelia Tee, Douglas Barker, Seung Kwak, Anka G Ehrhardt, Jean Paul Vonsattel, Kevin Correia, Michael J. Chao, Jacob M. Loupe, Darren G. Monckton, Alastair Maxwell, Jayalakshmi S. Mysore, Lesley Jones, Michael Orth, Richard H. Myers, Thomas Massey, Hugh Rickards, Ira Shoulson, Timothy Stone, Kyung Hee Kim, Marcy E. MacDonald, Marc Ciosi, Branduff McAllister, Erik van Duijn, Lynsey Hall, Tammy Gillis, Duncan McLauchlan, Jong-Min Lee, Ricardo Mouro Pinto, James F. Gusella, Eliana Marisa Ramos, Eun Pyo Hong, Jane S. Paulsen, Peter Holmans, G. Bernhard Landwehrmeyer, Cristina Sampaio, Afroditi Chatzi, Natalie Ellis, Kawther Abu Elneel, Jeffrey D. Long
Publikováno v:
Biological Psychiatry
Biological Psychiatry, 87(9), 857-865. ELSEVIER SCIENCE INC
Biological Psychiatry, 87(9), 857-865. ELSEVIER SCIENCE INC
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat in the HTT gene. It is diagnosed following a standardized exam of motor control and often presents with cognitive decline and psychiatric symptoms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf84e88303e099217205827749d27c51
https://doi.org/10.1016/j.biopsych.2019.12.010
https://doi.org/10.1016/j.biopsych.2019.12.010
Autor:
Gail Owen, Sherry Lifer, Dipinder Kaur, Jamie Levey, Filipe B. Rodrigues, Jee Bang, Swati Sathe, Jenny Townhill, Mark Guttman, Cristina Sampaio, Blair R. Leavitt, Jan Lewerenz, Anka G Ehrhardt, Elena Pak, Edward J. Wild, Katarzyna Schubert
STRUCTURED ABSTRACTBackgroundBiomarkers are needed to monitor disease progression, target engagement and efficacy in Huntington’s disease (HD). Cerebrospinal fluid (CSF) is an ideal medium to research such biomarkers due to its proximity to the bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b7901fc225e6f77250f363866c41e80
https://doi.org/10.1101/2021.07.30.21261340
https://doi.org/10.1101/2021.07.30.21261340
Publikováno v:
Bioanalysis. 8:2399-2413
Aim: Ki67 is a prognostic and/or predictive biomarker in patients with malignancies. Flow cytometry is a powerful technology for single-cell multiparameter analysis. Results: We developed and validated a multicolor quantitative flow cytometry assay f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33c643b694f9e88c6ecc04b54197e9a
https://doi.org/10.4155/bio-2016-0194
https://doi.org/10.4155/bio-2016-0194
Publikováno v:
Bioinformatics and Biology Insights
Bioinformatics and Biology Insights, Vol 13 (2019)
Bioinformatics and Biology Insights, Vol 13 (2019)
Advancements in flow cytometers with capability to measure 15 or more parameters have enabled us to characterize cell populations at unprecedented levels of detail. Beyond discovery research, there is now a growing demand to dive deeper into evaluati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c04a443e59fb0b93f1399a56a207806
http://europepmc.org/articles/PMC6448119
http://europepmc.org/articles/PMC6448119
Autor:
Diane Lucente, Douglas Barker, Michael J. Chao, Branduff McAllister, Georg Bernhard Landwehrmeyer, Abu Elneel K, Lynsey S. Hall, Jean-Paul Vonsattel, Jacob M. Loupe, Anka G Ehrhardt, J.S. Paulsen, Richard H. Myers, Vanessa C. Wheeler, Christopher W Medway, Jayalakshmi S. Mysore, Alastair Maxwell, Ira Shoulson, Tammy Gillis, Seung Kwak, Michael Orth, Peter Holmans, Timothy Stone, Lesley Jones, Eliana Marisa Ramos, J. F. Gusella, Cristina Sampaio, Eun Pyo Hong, Julianna Y. Lee, Dorsey Er, Mouro Pinto R, Kyuseok Kim, Kevin Correia, Jeffrey D. Long, Afroditi Chatzi, Tom Massey, Marcy E. MacDonald, Darren G. Monckton, Marc Ciosi
SUMMARYThe effects of variable, glutamine-encoding, CAA interruptions indicate that a property of the uninterrupted HTT CAG repeat sequence, distinct from huntingtin’s polyglutamine segment, dictates the rate at which HD develops. The timing of ons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a7aedebdf3a8a96b517070682019f9
https://doi.org/10.1101/529768
https://doi.org/10.1101/529768
Autor:
Dann L. Parker, Randal M. Bugianesi, Birgit T. Priest, Feroze Ujjainwalla, Edward C. Sherer, Stanley Mitelman, Sharon Tong, Matthew Lombardo, William K. Hagmann, Ravi P. Nargund, Melissa Costa, Christopher Joseph Sinz, Anka G. Ehrhardt, Scott D. Edmondson, Ravi Kurukulasuriya, Xiaofang Li, Karen H. Dingley, Kate Bender, Kevin S. Ratliff, Jonathan E. Wilson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2947-2951
A novel series of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists are described. The series was designed to address the suboptimal PK (pharmacokinetic) and off-target profile of a class of N-aryl-benzo-[1,4]-oxazepine-4-carboxamides, represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f4fd9aaf407b2d77d08816feb7cb20
https://doi.org/10.1016/j.bmcl.2016.04.018
https://doi.org/10.1016/j.bmcl.2016.04.018
Autor:
Seung Kwak, Adam Ellenberger, Edward J. Wild, Gail Owen, Anka G Ehrhardt, Elena Pak, Sherry Lifer, Cristina Sampaio
Publikováno v:
Clinical studies.
Background Earlier disease onset in subsequent generations, called anticipation, has been observed in HD families and is attributed to an increased CAG-repeat length in the HTT gene. CAG-repeat length mutations are referred to as ‘repeat instabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c04a2f3e83e76641f400245f4637102
https://doi.org/10.1136/jnnp-2018-ehdn.172
https://doi.org/10.1136/jnnp-2018-ehdn.172
Autor:
Anka G. Ehrhardt, Dipinder Kaur
Publikováno v:
Wet biomarkers.
Background and aim Biosample collection is essential to developing therapeutics for Huntington’s disease. Biosample collections are intended to accelerate progress towards the development of therapeutics that will benefit HD-affected individuals. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db2950e8f5a08084d5bf29e668a1a845
https://doi.org/10.1136/jnnp-2018-ehdn.84
https://doi.org/10.1136/jnnp-2018-ehdn.84