Zobrazeno 1 - 10
of 513
pro vyhledávání: '"G, Dighiero"'
Publikováno v:
The Journal of Immunology. 150:311-319
Three monoclonal IgG of different subclasses (IgG1, IgG2, and IgG4) and one IgA1 were isolated from the serum of patient Per suffering from an immunocytic sarcoma. All four monoclonal Ig shared the same N-terminal sequence of their H chains (VH3). Fu
Publikováno v:
Leukemia Research. 16:717-720
In the past few years important advances have been made in our understanding of the biology and natural history of CLL; also, new strategies and agents offer promise in the treatment of this form of leukemia. Now, patients can be treated on a more ra
Autor:
Enrique A. Mesri, Gabriela Levitus, M. H. V. van Regenmortel, G. Dighiero, M. Hontebeyrie-Joskowicz, Mariano J. Levin
Publikováno v:
Journal of Clinical Microbiology. 28:1219-1224
A Trypanosoma cruzi lambda gt11 cDNA clone, JL5, expressed a recombinant protein which was found to react predominantly with chronic Chagas' heart disease sera. The cloned 35-residue-long peptide was identified as the carboxyl-terminal portion of a T
Autor:
N Chiorazzi, T Logtenberg, G Dighiero, S Mechanic, L Borche, A Dimitriu-Bona, Lloyd Mayer, A Mannheimer-Lory, James A. Strauchen, R Mayer
Publikováno v:
Blood. 75:1518-1524
We studied the expression of CD5 and immunoglobulin variable gene families in a panel of monoclonal Epstein-Barr virus (EBV) transformed lines, chronic lymphocytic leukemias (CLLs) and CD5+ and CD5- B-cell lymphomas. The CD5 gene expression was in al
Autor:
G. Dighiero, P. Oppezzo
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 3540252797
B-CLL cells express CD5 and IgM/IgD and thus have a mantle zone-like phenotype of naive cells, which, in normal conditions express unmutated Ig genes. However, recent studies have shown that 50%–70% of CLL harbour somaticmutations of VH genes, as i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::624af5fab68b45593238db2dd83b44ab
https://doi.org/10.1007/3-540-29933-5_5
https://doi.org/10.1007/3-540-29933-5_5
Autor:
P, Oppezzo, G, Dighiero
Publikováno v:
Current topics in microbiology and immunology. 294
B-CLL cells express CD5 and IgM/IgD and thus have a mantle zone-like phenotype of naive cells, which, in normal conditions express unmutated Ig genes. However, recent studies have shown that 50%-70% of CLL harbour somatic mutations of VH genes, as if
Publikováno v:
British journal of haematology. 115(4)
Chronic lymphocytic leukaemia (CLL) remains an incurable disease. Although modern available treatments are able to induce disease regression, relapse almost inexorably occurs. Therefore, novel therapeutic strategies aimed at reducing the disease rela
Autor:
G, Dighiero
Publikováno v:
Hematology and cell therapy. 42(1)
Autor:
O, Pritsch, X, Troussard, C, Magnac, F R, Mauro, F, Davi, B, Payelle-Brogard, G, Dumas, M, Pulik, F, Clerget, F, Mandelli, N, Chiorazzi, H W, Schroeder, M, Leporrier, G, Dighiero
Publikováno v:
British journal of haematology. 107(3)
The excess risk of chronic lymphocytic leukaemia (CLL) in the first-degree relatives of affected patients suggests that familial CLL might constitute a useful model to study the pathogenesis of this disease, as has been demonstrated in numerous other
Publikováno v:
Blood. 94(10)
The B-cell antigen receptor (BCR) comprises membrane Igs (mIgs) and a heterodimer of Igalpha (CD79a) and Igbeta (CD79b) transmembrane proteins, encoded by the mb-1 and B29 genes, respectively. These accessory proteins are required for surface express