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Cell surface ADP-ribosyltransferase regulates lymphocyte function-associated molecule-1 (LFA-1) function in T cells

Autor: E Nemoto, Y Yu, G Dennert

Publikováno v: The Journal of Immunology. 157:3341-3349

Post-translational modifications are important in regulating the functions of signal proteins. This is well established for intracellular proteins, but little is known in the case of extracellular domains of cell surface molecules. We recently descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4c6e7902eb51b22f017ec84b406000b
https://doi.org/10.4049/jimmunol.157.8.3341

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Regulation of CTL by ecto-nictinamide adenine dinucleotide (NAD) involves ADP-ribosylation of a p56lck-associated protein

Autor: J Wang, E Nemoto, G Dennert

Publikováno v: The Journal of Immunology. 156:2819-2827

Receptor-mediated activation of T lymphocytes involves protein phosphorylation by several protein tyrosine kinases, among those the src-related enzymes p56lck and p59fyn. Accumulating evidence supports the notion that these enzymes are regulated by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d7e64265d19c04f97b2bc698abaafa0
https://doi.org/10.4049/jimmunol.156.8.2819

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Release of a glycosylphosphatidylinositol-anchored ADP-ribosyltransferase from cytotoxic T cells upon activation

Autor: E Nemoto, S Stohlman, G Dennert

Publikováno v: The Journal of Immunology. 156:85-92

Many cell surface proteins are anchored into the cell membrane by glycosylphosphatidylinositol (GPI), among those a recently discovered arginine-specific mono-ADP-ribosyltransferase on cytotoxic T cells (CTL). This enzyme transfers ADP-ribose to cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::226358df32dc4be66059acc765154238
https://doi.org/10.4049/jimmunol.156.1.85

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Acute rejection of marrow grafts in mice. Dependence on and independence of functional TCR in the rejection process

Autor: K Takeda, M W Moore, G Dennert

Publikováno v: The Journal of Immunology. 152:4407-4416

The question of how irradiated mice acutely reject marrow grafts has remained controversial, and evidence in support of T cell- and natural killer cell-mediated rejection mechanisms has been provided. Here we show in support of previous data that CB1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fc4faad9c1e408742821b35f5502d74
https://doi.org/10.4049/jimmunol.152.9.4407

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TCR cross-linking induces CTL death via internal action of TNF

Autor: J Wang, S A Stohlman, G Dennert

Publikováno v: The Journal of Immunology. 152:3824-3832

TCR-mediated stimulation can result in either activation or apoptosis, raising the question of what the mechanisms of these opposing effects might be. Here we demonstrate that microinjection of Ab specific for TNF inhibits activation-induced cell dea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b581d5e52f718cb9a53cbdc9da37d56
https://doi.org/10.4049/jimmunol.152.8.3824

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Evidence for a role for T cell receptors (TCR) in the effector phase of acute bone marrow graft rejection. TCR V beta 5 transgenic mice lack effector cells able to cause graft rejection

Autor: K Kikly, G Dennert

Publikováno v: The Journal of Immunology. 149:3489-3494

Lethally irradiated mice reject within 24 h certain marrow grafts, a phenomenon called either allogeneic or hybrid resistance. The cells responsible for this rejection (NK1+ CD3+ cells (TNK) express Ag of NK cells as well as the TCR-associated CD3 co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30d2a130bec7be9a3a9a547bb53b02ee
https://doi.org/10.4049/jimmunol.149.11.3489

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