Molecular Preadaptation to Antimony Resistance in Leishmania donovani on the Indian Subcontinent

Autor: F. Dumetz, B. Cuypers, H. Imamura, D. Zander, E. D’Haenens, I. Maes, M. A. Domagalska, J. Clos, J.-C. Dujardin, G. De Muylder

Publikováno v: mSphere, Vol 3, Iss 2 (2018)

ABSTRACT Antimonials (Sb) were used for decades for chemotherapy of visceral leishmaniasis (VL). Now abandoned in the Indian subcontinent (ISC) because of Leishmania donovani resistance, this drug offers a unique model for understanding drug resistan

Externí odkaz: https://doaj.org/article/49d1e1a7b21a47fe86a8b1efe9962b80

Genomic and phenotypic characterization of experimentally selected resistant Leishmania donovani reveals a role for dynamin-1 like protein in the mechanism of resistance to a novel anti-leishmanial compound

Autor: Matthew Berriman, Ilse Maes, Malgorzata A. Domagalska, Jeffrey N. Martin, Hideo Imamura, Mandy Sanders, Erika D’Haenens, Pieter Monsieurs, Jean-Claude Dujardin, Yann G.-J. Sterckx, G. De Muylder, James Cotton, Negreira Gh, Marlene Jara, H. De Winter, C. Mouchtoglou, Bart Cuypers, Aya Hefnawy

The implementation of prospective drug resistance (DR) studies in the R&D pipelines is a common practice for many infectious diseases, but not for Neglected Tropical Diseases. Here, we explored and demonstrated the importance of this approach, using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaeffa7bf4e9a1cdf1d2ac95d768c979
https://doi.org/10.1101/2021.01.05.425522

Molecular Preadaptation to Antimony Resistance in Leishmania donovani on the Indian Subcontinent

Autor: Malgorzata A. Domagalska, Hideo Imamura, Dorothea Zander, G. De Muylder, Joachim Clos, Ilse Maes, Bart Cuypers, Franck Dumetz, Erika D’Haenens, Jean-Claude Dujardin

Publikováno v: mSphere
mSphere, Vol 3, Iss 2, p e00548-17 (2018)
mSphere, Vol 3, Iss 2 (2018)

The “antibiotic resistance crisis” is a major challenge for scientists and medical professionals. This steady rise in drug-resistant pathogens also extends to parasitic diseases, with antimony being the first anti-Leishmania drug that fell in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd30048a9959b95e4a1d3da9512989f7
https://doi.org/10.1128/msphere.00548-17

Modulation of Aneuploidy in In Vivo Environments and Its Impact on Gene Expression

Autor: Jitka Myskova, Petr Volf, Franck Dumetz, Conor J. Meehan, G. De Muylder, Veronika Seblova, Mandy Sanders, Matthew Berriman, Giovanni Bussotti, Bart Cuypers, Manu Vanaerschot, Gerald F. Späth, J. R. Vermeesch, Pascale Pescher, Jean-Claude Dujardin, Malgorzata A. Domagalska, James Cotton, Hideo Imamura

Publikováno v: mBio, Vol 8, Iss 3 (2017)
mBio
mBio, 2017, pp.e00599-17. ⟨10.1128/mBio.00599-17⟩
mBio, American Society for Microbiology, 2017, pp.e00599-17. ⟨10.1128/mBio.00599-17⟩
mBio, Vol 8, Iss 3, p e00599-17 (2017)

Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and potentially beneficial in unicellular organisms, including pathogens. Leishmania , a major protozoan parasite, is emerging as a new model for aneuploidy, sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40d023c2318caa5776f26e50f2f3aba
https://journals.asm.org/doi/10.1128/mBio.00599-17

Knee neniscectomy: distant results

Autor: G, DE MUYLDER

Publikováno v: Acta chirurgica Belgica. (6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7efec173cda2e9f04ef6581ea3943a57
https://pubmed.ncbi.nlm.nih.gov/20270269