Zobrazeno 1 - 10
of 246
pro vyhledávání: '"G, Coughlin"'
Autor:
Justin G. Coughlin, Shih Ying Chang, Kenneth Craig, Charles Scarborough, Charles T. Driscoll, Christopher M. Clark, Nathan R. Pavlovic
Publikováno v:
Ecosphere, Vol 15, Iss 7, Pp n/a-n/a (2024)
Abstract Critical loads (CLs) are frequently used to quantify terrestrial ecosystem impacts from nitrogen (N) deposition using ecological responses such as the growth and mortality of tree species. Typically, CLs are reported as a single value, with
Externí odkaz:
https://doaj.org/article/d06143601e614d67b72e7c9ddccb4336
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Background Lewy body dementia (LBD) phenotype is associated with the presence and degree of Lewy body, Alzheimer’s pathologies, and substantia nigra neuron loss. Nigral neuron loss is associated with parkinsonism in LBD, and females with L
Externí odkaz:
https://doaj.org/article/0a341015ff6b49eab63fff57e44bfa09
Autor:
Ragini Phansalkar, Vanessa S. Goodwill, Jeffrey J. Nirschl, Chiara De Lillo, Jihee Choi, Elizabeth Spurlock, David G. Coughlin, Donald Pizzo, Christina J. Sigurdson, Annie Hiniker, Victor E. Alvarez, Ann C. Mckee, Jonathan H. Lin
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-10 (2023)
Abstract Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathology in CTE is characterized by neuronal loss, gliosis, and a distinctive pattern of neuronal accumulation of hyper-phos
Externí odkaz:
https://doaj.org/article/612dc488fe0f423f8daedf3b82d74059
Autor:
Julia Ting Bu, Dolores Torres, Adam Robinson, Corey Malone, Juan Carlos Vera, Shadi Daghighi, Anastasie Dunn-Pirio, Suzan Khoromi, Justin Nowell, Gabriel C. Léger, Joseph D. Ciacci, Vanessa S. Goodwill, Melanie Estrella, David G. Coughlin, Yueyang Guo, Nikdokht Farid
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Neuronal intranuclear inclusion disease (NIID), a neurodegenerative disease previously thought to be rare, is increasingly recognized despite heterogeneous clinical presentations. NIID is pathologically characterized by ubiquitin and p-62 positive in
Externí odkaz:
https://doaj.org/article/77c025534afb48718ca78af0976c0b92
Autor:
Nicolai Franzmeier, Matthias Brendel, Leonie Beyer, Luna Slemann, Gabor G. Kovacs, Thomas Arzberger, Carolin Kurz, Gesine Respondek, Milica J. Lukic, Davina Biel, Anna Rubinski, Lukas Frontzkowski, Selina Hummel, Andre Müller, Anika Finze, Carla Palleis, Emanuel Joseph, Endy Weidinger, Sabrina Katzdobler, Mengmeng Song, Gloria Biechele, Maike Kern, Maximilian Scheifele, Boris-Stephan Rauchmann, Robert Perneczky, Michael Rullman, Marianne Patt, Andreas Schildan, Henryk Barthel, Osama Sabri, Jost J. Rumpf, Matthias L. Schroeter, Joseph Classen, Victor Villemagne, John Seibyl, Andrew W. Stephens, Edward B. Lee, David G. Coughlin, Armin Giese, Murray Grossman, Corey T. McMillan, Ellen Gelpi, Laura Molina-Porcel, Yaroslau Compta, John C. van Swieten, Laura Donker Laat, Claire Troakes, Safa Al-Sarraj, John L. Robinson, Sharon X. Xie, David J. Irwin, Sigrun Roeber, Jochen Herms, Mikael Simons, Peter Bartenstein, Virginia M. Lee, John Q. Trojanowski, Johannes Levin, Günter Höglinger, Michael Ewers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
Externí odkaz:
https://doaj.org/article/bd1a4c237aa0450eb6ad79b56669c4c6
Autor:
David G. Coughlin, H. Branch Coslett, Claire Peterson, Jeffrey S. Phillips, Corey McMillan, Edward B. Lee, John Q. Trojanowski, Murray Grossman, David J. Irwin
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Lewy body diseases are pathologically characterized by α‐synuclein pathology. Alzheimer's disease (AD) co‐pathology can influence phenotypes. In vivo AD biomarkers can suggest the presence of this co‐pathology in unusual
Externí odkaz:
https://doaj.org/article/08c1dc227b1d40899f01c3f14a58ef8b
Autor:
David G Coughlin, Annie Hiniker, Claire Peterson, Yongya Kim, Sanaz Arezoumandan, Lucia Giannini, Donald Pizzo, Daniel Weintraub, Andrew Siderowf, Irene Litvan, Robert A Rissman, Douglas Galasko, Lawrence Hansen, John Q Trojanowski, Edward Lee, Murray Grossman, David Irwin
Publikováno v:
Journal of Neuropathology and Experimental Neurology, 81(12), 953-964. Oxford University Press
3R/4R-tau species are found in Alzheimer disease (AD) and ∼50% of Lewy body dementias at autopsy (LBD+tau); 4R-tau accumulations are found in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Digital image analysis technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7171ee88cd49492cb9bdc147c223dc5f
https://doi.org/10.1093/jnen/nlac094
https://doi.org/10.1093/jnen/nlac094
Publikováno v:
Tremor and Other Hyperkinetic Movements, Pp 1-4 (2018)
Background: Hereditary myoclonus dystonia is often due to changes in the SGCE gene. Dystonia (DYT)-SGCE has a variable phenotype that can involve focal or generalized myoclonus and various forms of task-specific, segmental, or generalized dystonia. P
Externí odkaz:
https://doaj.org/article/99cbbee7c42341d6acd3d6368626cd0a
Autor:
David G. Coughlin, Vanessa S. Goodwill, Heidi G. Standke, Yongya Kim, Nicolas Coley, Donald P. Pizzo, Douglas Galasko, Allison Kraus, Annie Hiniker
Publikováno v:
Acta Neuropathologica. 144:789-792
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27144a549e1621f427934e95365e7fc1
https://doi.org/10.1007/s00401-022-02480-x
https://doi.org/10.1007/s00401-022-02480-x
Autor:
David G Coughlin, Irene Litvan
Publikováno v:
Expert Opinion on Investigational Drugs. 31:813-823
Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disease marked by a variety of movement, ocular, and cognitive symptoms. Currently, treatment is symptomatic, and there are no disease-modulating therapies. While clinical presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1aff5dd2802423f809c39fc1818b2fd
https://doi.org/10.1080/13543784.2022.2087179
https://doi.org/10.1080/13543784.2022.2087179