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Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer

Autor: D M, Shin, N J, Donato, R, Perez-Soler, H J, Shin, J Y, Wu, P, Zhang, K, Lawhorn, F R, Khuri, B S, Glisson, J, Myers, G, Clayman, D, Pfister, J, Falcey, H, Waksal, J, Mendelsohn, W K, Hong

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(5)

C225, a human-mouse chimerized monoclonal antibody directed against the epidermal growth factor receptor (EGFr), has a synergistic effect with cisplatin in xenograft models. To determine the tumor EGFr saturation dose with C225 and the fate of infuse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4684c649ce32a7c3eaebf743d3c0112e
https://pubmed.ncbi.nlm.nih.gov/11350885

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Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer

Autor: M, Duvic, B, Helekar, C, Schulz, M, Cho, D, DiSepio, C, Hager, D, DiMao, P, Hazarika, B, Jackson, J, Breuer-McHam, J, Young, G, Clayman, S M, Lippman, R A, Chandraratna, N A, Robinson, A, Deucher, R L, Eckert, S, Nagpal

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(8)

Tazarotene-induced gene-3 (TIG-3), isolated from human keratinocytes treated with the retinoic acid receptor-selective retinoid Tazarotene, is homologous to H-rev, a class II tumor suppressor. TIG-3 gene localized to chromosome 11q23, a site of loss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd65f6fefa9406e053d06252622f7c6c
https://pubmed.ncbi.nlm.nih.gov/10955811

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Presence of multiple incontiguous deleted regions at the long arm of chromosome 18 in head and neck cancer

Autor: V A, Papadimitrakopoulou, Y, Oh, A, El-Naggar, J, Izzo, G, Clayman, L, Mao

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(3)

The 18q chromosomal region is frequently lost in head and neck squamous cell carcinomas (HNSCCs). Several candidate tumor suppressor genes have been mapped to this chromosomal region, including DCC, DPC4, and MADR2. The latter two genes are members o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9eb082c87e579f7118a7ea509e58e54e
https://pubmed.ncbi.nlm.nih.gov/9533520

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Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53

Autor: K K, Hunt, J, Deng, T J, Liu, M, Wilson-Heiner, S G, Swisher, G, Clayman, M C, Hung

Publikováno v: Cancer research. 57(21)

Apoptosis is a mode of cell death that is carefully regulated based on cellular and environmental signals. The ability to modulate the individual cellular machinery and thereby to promote apoptosis is an important strategy in cancer therapy. It has p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65070d6dad8300d1bad204fecba27d5f
https://pubmed.ncbi.nlm.nih.gov/9354430

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DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma

Autor: S K, Kim, Y, Fan, V, Papadimitrakopoulou, G, Clayman, W N, Hittelman, W K, Hong, R, Lotan, L, Mao

Publikováno v: Cancer research. 56(11)

DPC4, a candidate tumor suppressor gene, was identified recently at chromosome 18q21.1. Frequent homozygous deletion or mutations of the gene were observed in pancreatic carcinomas. To investigate the role of this gene in head and neck squamous cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00a93906fee9217f0552e2b1adf3b872
https://pubmed.ncbi.nlm.nih.gov/8653689

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Genetic progression model for head and neck cancer: implications for field cancerization

Autor: J, Califano, P, van der Riet, W, Westra, H, Nawroz, G, Clayman, S, Piantadosi, R, Corio, D, Lee, B, Greenberg, W, Koch, D, Sidransky

Publikováno v: Cancer research. 56(11)

A genetic progression model of head and neck squamous cell carcinoma has not yet been elucidated, and the genetic basis for "field cancerization" of the aerodigestive tract has also remained obscure. Eighty-seven lesions of the head and neck, includi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1128c7b81bd7fc41b819b39d857fd91f
https://pubmed.ncbi.nlm.nih.gov/8653682

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S5.3 Oral tongue and floor of mouth cancer management

Autor: G. Clayman

Publikováno v: Oral Oncology Supplement. 1:51

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32ae4b83a141cfb300ed1393d15de8fc
https://doi.org/10.1016/s1744-7895(05)80072-0

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Somogyi effect in treatment of diabetes

Autor: Sidney G. Clayman

Publikováno v: JAMA. 214(6)

To The Editor.— The well-known Somogyi effect in insulin treatment of diabetes mellitus is frequently overlooked. This is the form of insulin resistance due to chronic overdosage, described by Somogyi in 1959. Due to repeated insulin overdosage, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafff9b6cedb23bfb0aa9dc4e0c4df3b
https://pubmed.ncbi.nlm.nih.gov/5536257

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