Zobrazeno 1 - 10
of 100
pro vyhledávání: '"G, Boulu"'
Autor:
G Saliou, G. Boulu, B. Bonnaire, B Vanden Abeel, Pierre Lehmann, M Kocheida, Jean-Noël Vallée, J Vernois, A. Le Blanche
Publikováno v:
Journal de Radiologie. 88:541-547
Emergency departments frequently encounter pathology resulting from injury to the foot and ankle, with approximately 6000 case per day in France. In an ankle sprain, 85% of the lesions involve the lateral collateral ligament. Many other, much rarer,
Autor:
Roger G. Boulu, Catherine Verrecchia, Michel Plotkine, Christian Mésenge, Christiane Charriaut-Marlangue
Publikováno v:
Bulletin de l'Académie Nationale de Médecine. 185:555-565
RESUME La poly (ADP-ribose) polymerase (PARP, EC 2.4.2.30) est une enzyme constitutive nucleaire liee a la chromatine. Elle est egalement appelee poly (ADP-ribose) synthase (PARS) ou poly (ADP-ribose) transferase (PADRT). A la suite d’une lesion de
Publikováno v:
British Journal of Pharmacology. 125:584-590
1 The aim of this study was to assess whether an excitotoxic insult induced by NMDA may induce an iNOS activity which contributes to the lesion in the rat striatum. 2 For this purpose, rats were perfused with 10 mM NMDA through a microdialysis probe
Autor:
Roger G. Boulu, Laurent Lecanu, Michel Plotkine, Hicham Boughali, Isabelle Margaill, Bertrand Cohen-Tenoudji
Publikováno v:
NeuroReport. 9:559-563
The aim of this study was to assess whether oxidative stress induces deleterious NOS activity in the central nervous system (CNS). For this purpose, the mitochondrial toxin malonate, which promotes free radical production, was infused into the left s
Publikováno v:
British Journal of Pharmacology. 122:625-630
1. The temporal changes in constitutive NO-synthase (cNOS) and in calcium-independent NO-synthase activities were studied in mice subjected to 2 h of transient focal cerebral ischaemia. The changes in brain nitrites/nitrates (NOx) content were also s
Publikováno v:
Free Radical Biology and Medicine. 23:1031-1034
Various in vitro experiments have indicated that oxygen-derived free radicals may contribute to excitotoxic neuronal death. In the present study we induced excitotoxicity in rat striatum by perfusing glutamate at a high concentration through a microd
Publikováno v:
British Journal of Pharmacology. 120:160-163
In this study the effect of the dose and administration time of NG-nitro-l-arginine methyl ester (l-NAME), an NO-synthase inhibitor, in a model of transient focal cerebral ischaemia in rats was investigated. Two injections of l-NAME were given, of 1,
Autor:
Isabelle Margaill, Roger G. Boulu, S. Parmentier, Jacques Callebert, Michel Plotkine, Monique Allix
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 16:107-113
The present study investigates the role of N-methyl-D-aspartate (NMDA) receptors in a model of transient focal cerebral ischemia in normotensive rats. The left middle cerebral artery and both common carotid arteries were occluded for 60 min. Prelimin
Autor:
Marie-Louise Revaud, Roger G. Boulu, Michel Plotkine, Eric Lancelot, Jacques Callebert, Dominique Lerouet
Publikováno v:
Neuroscience Letters. 202:21-24
In the present study, using the microdialysis technique, we provided evidence of the existence of hydroxyl radicals ( · OH) in the striatum of awake rats under physiological conditions. This · OH generation was virtually abolished by the N -methyl-
Publikováno v:
Neuroscience Letters. 197:85-88
As increasing arguments suggest that the reperfusion phase following an ischemic insult may aggravate tissue injury by yielding hydroxyl radicals (OH), we examined whether these oxyradicals are generated in rat striatum during transient focal cerebra