Výsledky vyhledávání

Six at Six: Interleukin-6 Measured 6 H After the Initiation of Sepsis Predicts Mortality Over 3 Days

Autor: Jungsoon Shin, Daniel G. Remick, Javed Siddiqui, Jean A. Nemzek, G. Bolgos

Publikováno v: Shock. 17:463-467

Virtually of the all recent therapeutic interventions for treating sepsis have failed to improve survival. One potential explanation is that the heterogeneity of the immune response to the septic challenge is such that only a portion of the patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaca224fab7cacfae5e155ec9d9643ae
https://doi.org/10.1097/00024382-200206000-00004

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Autor: Daniel G. Remick, Xian Wang, G. Bolgos, Samuel J. Ebong, Douglas R. Call, David E. Newcomb

Publikováno v: Inflammation. 26:167-174

The secretion of calcitonin gene-related peptide (CGRP) and the chemokines KC and MIP-2 are increased in the animal models of endotoxemic and septic shock. We tested whether CGRP could modulate KC and MIP-2 secretion from different sources of macroph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cac557119a4bf4ae718259fee5e35143
https://doi.org/10.1023/a:1016515712344

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Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia

Autor: M K Eskandari, G Bolgos, C Miller, D T Nguyen, L E DeForge, D G Remick

Publikováno v: The Journal of Immunology. 148:2724-2730

Cytokines have been studied intensively to delineate their role in the altered pathophysiology observed in septic shock. We studied the role of TNF in the lethality of two well characterized models of septic shock by inhibiting TNF's activity with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9986fc825c7017940abf73fe8a220a48
https://doi.org/10.4049/jimmunol.148.9.2724

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Measuring acute changes in adrenergic nerve activity of the heart in the living animal

Autor: G. Bolgos, Jon W. Johnson, James C. Sisson

Publikováno v: American Heart Journal. 121:1119-1123

Changes in the function of the adrenergic neurons of the heart may be important indicators of the adaptations of an animal to physiologic stress and disease. Rates of loss of norepinephrine (NE) from the heart were considered to be proportional to NE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a3d1a3c7346e7a4db0ea013489097b
https://doi.org/10.1016/0002-8703(91)90671-4

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Differential local and systemic regulation of the murine chemokines KC and MIP2

Autor: Samuel J. Ebong, Daniel G. Remick, Gordon Wollenberg, Douglas R. Call, G. Bolgos, David E. Newcomb, Jean A. Nemzek

Publikováno v: Shock (Augusta, Ga.). 15(4)

We characterized the relative biological activity and expression of two murine chemokines that may serve as functional homologues for human IL-8, KC, and macrophage inflammatory protein 2 (MIP2). Recombinant chemokines were produced in bacterial expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66b677f635d14577057508783c77e20
https://pubmed.ncbi.nlm.nih.gov/11303726

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Scintigraphic portrayal of beta receptors in the heart

Autor: J C, Sisson, D M, Wieland, R A, Koeppe, D, Normolle, K A, Frey, G, Bolgos, J, Johnson, M E, Van Dort, D L, Gildersleeve

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 32(7)

Myocardial beta adrenergic receptors play important roles in physiology and disease, but the receptors have not before been portrayed. The beta antagonist, iodocyanopindolol (ICYP), was used to develop a scintigraphic method for depicting the recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42f100f945abfc3c437cae145e07ff03
https://pubmed.ncbi.nlm.nih.gov/1648608

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Portrayal of adrenergic denervation in the presence of myocardial infarction: a feasibility study

Autor: J C, Sisson, J, Johnson, G, Bolgos, J J, Lynch, A, Uprichard, E, Driscoll, D M, Wieland, B, Lucchesi

Publikováno v: American journal of physiologic imaging. 5(4)

Myocardial infarction interrupts adrenergic neurons beyond the region of necrosis to give peri-infarct denervation. A method to define the regions of denervation would be a valuable aid in determining the role that loss of adrenergic neurons plays in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c43f884d26011906a269a71f3ab983d6
https://pubmed.ncbi.nlm.nih.gov/2090166

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