Zobrazeno 1 - 10
of 99
pro vyhledávání: '"G, Berthiaume"'
Autor:
Erwan Beauchamp, Jay M. Gamma, Christopher R. Cromwell, Eman W. Moussa, Rony Pain, Morris A. Kostiuk, Claudia Acevedo-Morantes, Aishwarya Iyer, Megan Yap, Krista M. Vincent, Lynne M. Postovit, Olivier Julien, Basil P. Hubbard, John R. Mackey, Luc G. Berthiaume
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-28 (2024)
Abstract Background In humans, two ubiquitously expressed N-myristoyltransferases, NMT1 and NMT2, catalyze myristate transfer to proteins to facilitate membrane targeting and signaling. We investigated the expression of NMTs in numerous cancers and f
Externí odkaz:
https://doaj.org/article/e374a30553c44d19b689e30c333e8d47
Publikováno v:
PLoS ONE, Vol 19, Iss 9, p e0308500 (2024)
Glutathione transferase P1 (GSTP1) is a multi-functional protein that protects cells from electrophiles by catalyzing their conjugation with glutathione, and contributes to the regulation of cell proliferation, apoptosis, and signalling. GSTP1, usual
Externí odkaz:
https://doaj.org/article/ed80b1fb32e747e39ace81c29e75009c
Autor:
Randeep Sangha, Neal M. Davies, Afshin Namdar, Michael Chu, Jennifer Spratlin, Erwan Beauchamp, Luc G. Berthiaume, John R. Mackey
Publikováno v:
Current Oncology, Vol 29, Iss 3, Pp 1939-1946 (2022)
Patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) have limited treatment options, particularly if they are transplantation or chimeric antigen receptor (CAR) T-cell ineligible, and novel therapeutics are needed. An 86-year-ol
Externí odkaz:
https://doaj.org/article/bc7e32c7ed9e44a19c59822c4b50dbea
Autor:
Erwan Beauchamp, Megan C. Yap, Aishwarya Iyer, Maneka A. Perinpanayagam, Jay M. Gamma, Krista M. Vincent, Manikandan Lakshmanan, Anandhkumar Raju, Vinay Tergaonkar, Soo Yong Tan, Soon Thye Lim, Wei-Feng Dong, Lynne M. Postovit, Kevin D. Read, David W. Gray, Paul G. Wyatt, John R. Mackey, Luc G. Berthiaume
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
N-myristoyltransferases (NMTs) target many signaling proteins to membranes. Here the authors show an NMT inhibitor named PCLX-001 selectively kills lymphoma cells by shutting down their main survival signaling pathway and offers an additional treatme
Externí odkaz:
https://doaj.org/article/bfdadd6d979a442fbc358345f3c1fc33
Autor:
Jay Gamma, Erwan Beauchamp, Qiang Liu, Aishwarya Iyer, Megan Yap, Zoulika Zak, Cassidy Ekstrom, Krista Vincent, Joseph Brandwein, Jean C.Y. Wang, Naveen Pemmaraju, Gautam Borthakur, John R. Mackey, Luc G. Berthiaume
Publikováno v:
Blood. 140:3088-3089
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::909bf86bf40f255133c171956a542a15
https://doi.org/10.1182/blood-2022-170544
https://doi.org/10.1182/blood-2022-170544
Autor:
Randeep Sangha, Laurie H. Sehn, Rahima Jamal, Jennifer Spratlin, John Kuruvilla, Michael J. Weickert, Luc G. Berthiaume, John R. Mackey
Publikováno v:
Blood. 140:12057-12058
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::544f0500c7edc962441994f8ac3d8878
https://doi.org/10.1182/blood-2022-168140
https://doi.org/10.1182/blood-2022-168140
Autor:
Megan C. Yap, Morris A. Kostiuk, Dale D.O. Martin, Maneka A. Perinpanayagam, Pieter G. Hak, Anjaiah Siddam, Janaki R. Majjigapu, Gurram Rajaiah, Bernd O. Keller, Jennifer A. Prescher, Peng Wu, Carolyn R. Bertozzi, John R. Falck, Luc G. Berthiaume
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 6, Pp 1566-1580 (2010)
Progress in understanding the biology of protein fatty acylation has been impeded by the lack of rapid direct detection and identification methods. We first report that a synthetic ω-alkynyl-palmitate analog can be readily and specifically incorpora
Externí odkaz:
https://doaj.org/article/e7d2d9c6da9e49e38aa1a204fd92151c
Autor:
Maneka A. Perinpanayagam, John R. Mackey, Soon Thye Lim, Manikandan Lakshmanan, Aishwarya Iyer, Anandhkumar Raju, Paul G. Wyatt, Vinay Tergaonkar, Lynne M. Postovit, Kevin D. Read, Krista Vincent, Luc G. Berthiaume, Soo Yong Tan, Megan C. Yap, Jay M. Gamma, Erwan Beauchamp, David W. Gray, Wei-Feng Dong
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Myristoylation, the N-terminal modification of proteins with the fatty acid myristate, is critical for membrane targeting and cell signaling. Because cancer cells often have increased N-myristoyltransferase (NMT) expression, NMTs were proposed as ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9045022f419e26bc74a7f4c1af0bd4a2
https://doi.org/10.1038/s41467-020-18998-1
https://doi.org/10.1038/s41467-020-18998-1
Autor:
Utkarsh Chauhan, Luc G. Berthiaume, Raymond Lai, Wei-Feng Dong, Sunita Ghosh, Justine Lai, John R. Mackey, Yie-Wei Sim, Darryl D. Glubrecht, Erwan Beauchamp, Gilbert Bigras
Publikováno v:
Breast Cancer Research and Treatment
Purpose N-myristoyltransferases 1 and 2 (NMT1 and NMT2) catalyze the addition of 14-carbon fatty acids to the N-terminus of proteins. Myristoylation regulates numerous membrane-bound signal transduction pathways important in cancer biology and the pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e23027a5dedf8ca65f416e49f9320ba
https://pubmed.ncbi.nlm.nih.gov/33398478
https://pubmed.ncbi.nlm.nih.gov/33398478
Autor:
Luc G. Berthiaume, Randeep Sangha, Laurie H. Sehn, John Kuruvilla, John R. Mackey, Michael J. Weickert
Publikováno v:
Blood. 138:1364-1364
Background: Myristoylation regulates numerous membrane-bound signal transduction pathways important in cancer biology. This modification is catalyzed by N-myristoyltransferases 1 and 2 (NMT1 and NMT2). PCLX-001 is an oral small molecule with high aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ca37cfc764618c3d732f42bc97a5b4
https://doi.org/10.1182/blood-2021-153613
https://doi.org/10.1182/blood-2021-153613