Zobrazeno 1 - 10
of 401
pro vyhledávání: '"G, Beaumont"'
Autor:
Jens Hansen, Yuguang Xiong, Mustafa M. Siddiq, Priyanka Dhanan, Bin Hu, Bhavana Shewale, Arjun S. Yadaw, Gomathi Jayaraman, Rosa E. Tolentino, Yibang Chen, Pedro Martinez, Kristin G. Beaumont, Robert Sebra, Dusica Vidovic, Stephan C. Schürer, Joseph Goldfarb, James M. Gallo, Marc R. Birtwistle, Eric A. Sobie, Evren U. Azeloglu, Seth I. Berger, Angel Chan, Christoph Schaniel, Nicole C. Dubois, Ravi Iyengar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardiom
Externí odkaz:
https://doaj.org/article/5c705931ae3749d8b0d5c464d5e8d788
Autor:
Li Wang, Sudeh Izadmehr, John P. Sfakianos, Michelle Tran, Kristin G. Beaumont, Rachel Brody, Carlos Cordon-Cardo, Amir Horowitz, Robert Sebra, William K. Oh, Nina Bhardwaj, Matthew D. Galsky, Jun Zhu
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109928- (2024)
Summary: Interactions within the tumor microenvironment (TME) significantly influence tumor progression and treatment responses. While single-cell RNA sequencing (scRNA-seq) and spatial genomics facilitate TME exploration, many clinical cohorts are a
Externí odkaz:
https://doaj.org/article/78cfe216b02f40508c2ce44eed5d4500
Autor:
Mustafa M. Siddiq, Carlos A. Toro, Nicholas P. Johnson, Jens Hansen, Yuguang Xiong, Wilfredo Mellado, Rosa E. Tolentino, Kaitlin Johnson, Gomathi Jayaraman, Zaara Suhail, Lauren Harlow, Jinye Dai, Kristin G. Beaumont, Robert Sebra, Dianna E. Willis, Christopher P. Cardozo, Ravi Iyengar
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionNeurons transport mRNA and translational machinery to axons for local translation. After spinal cord injury (SCI), de novo translation is assumed to enable neurorepair. Knowledge of the identity of axonal mRNAs that participate in neurore
Externí odkaz:
https://doaj.org/article/e7907528427c4cc4850262c458caa737
Autor:
Susana I. Ramos, Zarmeen M. Mussa, Elisa N. Falk, Balagopal Pai, Bruno Giotti, Kimaada Allette, Peiwen Cai, Fumiko Dekio, Robert Sebra, Kristin G. Beaumont, Alexander M. Tsankov, Nadejda M. Tsankova
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Late prenatal development of the human neocortex encompasses a critical period of gliogenesis and cortical expansion. Here, authors use human transcriptomics to capture transience and diversity of cells in middle and late prenatal development, includ
Externí odkaz:
https://doaj.org/article/f31342a967ee47e0acf711c820e990c0
Autor:
Balagopal Pai, Jessica Tome-Garcia, Wan Sze Cheng, German Nudelman, Kristin G. Beaumont, Saadi Ghatan, Fedor Panov, Elodia Caballero, Kwadwo Sarpong, Lara Marcuse, Jiyeoun Yoo, Yan Jiang, Anne Schaefer, Schahram Akbarian, Robert Sebra, Dalila Pinto, Elena Zaslavsky, Nadejda M. Tsankova
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)
Abstract The pathophysiology of epilepsy underlies a complex network dysfunction between neurons and glia, the molecular cell type-specific contributions of which remain poorly defined in the human disease. In this study, we validated a method that s
Externí odkaz:
https://doaj.org/article/b9a46178f9344e43baf3916ddbf90fec
Autor:
Tracey L. Freeman, Connie Zhao, Nadine Schrode, Trinisia Fortune, Sanjana Shroff, Benjamin Tweel, Kristin G. Beaumont, Talia H. Swartz
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHuman immunodeficiency virus type 1 (HIV-1) causes a chronic, incurable infection leading to immune activation and chronic inflammation in people with HIV-1 (PWH), even with virologic suppression on antiretroviral therapy (ART). The role
Externí odkaz:
https://doaj.org/article/d384da5a4f1c4d81ac78f7ab22bde636
Autor:
Balagopal Pai, Jessica Tome‑Garcia, Wan Sze Cheng, German Nudelman, Kristin G. Beaumont, Saadi Ghatan, Fedor Panov, Elodia Caballero, Kwadwo Sarpong, Lara Marcuse, Jiyeoun Yoo, Yan Jiang, Anne Schaefer, Schahram Akbarian, Robert Sebra, Dalila Pinto, Elena Zaslavsky, Nadejda M. Tsankova
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/7d07701130ab484cb8642f0fb82b0e9b
Publikováno v:
Vaccines, Vol 10, Iss 10, p 1716 (2022)
The virus that causes COVID-19 changes over time, occasionally leading to Variants of Interest (VOIs) and Variants of Concern (VOCs) that can behave differently with respect to detection kits, treatments, or vaccines. For instance, two vaccination do
Externí odkaz:
https://doaj.org/article/ca6b7ca5a0d24001a0af8573d7075c66
Autor:
Luena Papa, Mansour Djedaini, Tiphaine C. Martin, Mahtab Zangui, Kristin G. Beaumont, Robert Sebra, Ramon Parsons, Christoph Schaniel, Ronald Hoffman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Ex vivo expansion strategies of human hematopoietic stem cell (HSC) grafts with suboptimal stem cell dose have emerged as promising strategies for improving outcomes of HSC transplantation in patients with hematological malignancies. While exposure o
Externí odkaz:
https://doaj.org/article/81e1d7290d9e49df8cb28b6a6ed70a9b
Autor:
Andrew L. H. Webster, Mathijs A. Sanders, Krupa Patel, Ralf Dietrich, Raymond J. Noonan, Francis P. Lach, Ryan R. White, Audrey Goldfarb, Kevin Hadi, Matthew M. Edwards, Frank X. Donovan, Remco M. Hoogenboezem, Moonjung Jung, Sunandini Sridhar, Tom F. Wiley, Olivier Fedrigo, Huasong Tian, Joel Rosiene, Thomas Heineman, Jennifer A. Kennedy, Lorenzo Bean, Rasim O. Rosti, Rebecca Tryon, Ashlyn-Maree Gonzalez, Allana Rosenberg, Ji-Dung Luo, Thomas S. Carroll, Sanjana Shroff, Michael Beaumont, Eunike Velleuer, Jeff C. Rastatter, Susanne I. Wells, Jordi Surrallés, Grover Bagby, Margaret L. MacMillan, John E. Wagner, Maria Cancio, Farid Boulad, Theresa Scognamiglio, Roger Vaughan, Kristin G. Beaumont, Amnon Koren, Marcin Imielinski, Settara C. Chandrasekharappa, Arleen D. Auerbach, Bhuvanesh Singh, David I. Kutler, Peter J. Campbell, Agata Smogorzewska
Publikováno v:
Nature, 612(7940), 495-502. Nature Publishing Group
Nature
Nature
Fanconi anaemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink repair resulting in chromosome breakage1–3. The FA repair pathway protects against endogenous and exogenous carcinogenic aldehydes4