Projecting the impact of triple CFTR modulator therapy on intravenous antibiotic requirements in cystic fibrosis using patient registry data combined with treatment effects from randomised trials

Autor: Karla Diaz-Ordaz, Rebecca Cosgriff, Gary Connett, Maarten van Smeden, Keith G. Brownlee, Emily Granger, Clemence Leyrat, Eleni-Rosalina Andrinopoulou, Rhonda D. Szczesniak, Nicholas P. Jewell, Ruth H. Keogh, Siobhán B. Carr, Daniela K Schlüter, Alex Lewin

Publikováno v: Thorax
Thorax, 77(9), 873-881. BMJ Publishing Group

Background: cystic fibrosis (CF) is a life-threatening genetic disease, affecting around 10 500 people in the UK. Precision medicines have been developed to treat specific CF-gene mutations. The newest, elexacaftor/tezacaftor/ivacaftor (ELEX/TEZ/IVA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763d7a118dfbd5e597faa95ce28d4bb2
http://www.scopus.com/inward/record.url?scp=85136909554&partnerID=8YFLogxK

Incidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020

Autor: Halyna Makukh, Andrea Dugac Vukic, Meir Mei-Zahav, Tsitsino Parulava, Harriet Corvol, Godfrey Fletcher, Rita Padoan, S. Fustik, Silke van Koningsbruggen-Rietschel, Fiona Dunlevy, Andreas Jung, Hana Kayserova, Satenik Harutyunyan, Siobhán B. Carr, Domenique Zomer-van Ommen, Łukasz Woźniacki, Svetlana Keegan, Elena Kondratyeva, Jacqui G. van Rens, Elpis Hatziagorou, Carla Colombo, Pedro Mondejar-Lopez, Vincent Gulmans, Anita Senstad Wathne, María Dolores Pastor-Vivero, Milan Macek, Egil Bakkeheim, Milan Rodić, Sevgi Pekcan, Filia Diamantea, Elliott McClenaghan, Géraldine Daneau, Guergana Petrova, Kęstutis Malakauskas, Marko Krasnyk, Yasemin Gokdemir, Panayiotis K. Yiallouros, Elise Lammertyn, Marc Schlesser, Edward F. McKone, Andreas Pfleger, Olga I. Simonova, Luísa Pereira, Elena Zhekaite, Anders Lindblad, Oxana Turcu, Andrea Párniczky, Isabelle de Monestrol, Duška Tješić-Drinković, Elina Aleksejeva, Uro Krivecs, Lutz Naehrlich, Elena Amelina, A. Zolin, Pierre-Régis Burgel, Vladimir Bobrovnichy, Annalisa Orenti, Alena Bilkova, Deniz Dogru, Liviu Pop, Marco Salvatore, Nataliya Kashirskaya, Irena Kasmi, Keith G. Brownlee, Pavel Drevinek, Hanne Vebert Olesen, Rebecca Cosgriff, Lydie Lemonnier-Videau, A. Fox, Ivan Bambir

Publikováno v: Naehrlich, L, Orenti, A, Dunlevy, F, Kasmi, I, Harutyunyan, S, Pfleger, A, Keegan, S, Daneau, G, Petrova, G, Tješić-Drinković, D, Yiallouros, P, Bilkova, A, Olesen, H V, Burgel, P R, Parulava, T, Diamantea, F, Párniczky, A, McKone, E F, Mei-Zahav, M, Salvatore, M, Colombo, C, Aleksejeva, E, Malakauskas, K, Schlesser, M, Fustik, S, Turcu, O, Zomer-van Ommen, D, Wathne, A S, Woźniacki, Ł, Pereira, L, Pop, L, Kashirskaya, N, Rodić, M, Kayserova, H, Krivecs, U, Mondejar-Lopez, P, de Monestrol, I, Dogru, D, Makukh, H, Cosgriff, R, van Koningsbruggen-Rietschel, S, Jung, A & European Cystic Fibrosis COVID project group 2021, ' Incidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020 ', Journal of Cystic Fibrosis, vol. 20, no. 4, pp. 566-577 . https://doi.org/10.1016/j.jcf.2021.03.017
Journal of Cystic Fibrosis

Background: Viral infections can cause significant morbidity in cystic fibrosis (CF). The current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic could therefore have a serious impact on the health of people with CF (pwCF). Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890c3cc12ea4caf2f33deed43b74c782
https://pure.au.dk/ws/files/275030134/1_s2.0_S1569199321000990_main.pdf

COVID-19 vaccine prioritisation for people with cystic fibrosis

Autor: Satenik Harutyunyan, Marco Salvatore, Rasa Ruseckaite, Elena Zhekayte, Keith G. Brownlee, Albert Faro, Luiz Vicente Ribeiro Ferreira da Silva Filho, Catherine A. Byrnes, Samar Rizvi, Siobhán B. Carr, Elena Kondratyeva, Andeas Jung, Harriet Corvol, Pierre Régis Burgel, Pedro Mondejar-Lopez, Bruce C. Marshall, Olzhas Abdrakhmanov, Géraldine Daneau, Peter G. Middleton, Susannah Ahern, Nataliya Kashirskaya, Lutz Nährlich, Alexander Elbert, Marco Zampoli, Vincent Gulmans, Elliot McClenaghan, Isabelle de Monestrol, M. Dolores Pastor-Vivero, R. Padoan, Hector Gutierrez, Joel Melo, Carla Colombo, Stephanie Y. Cheng, Christopher H. Goss, Anne L. Stephenson, Elena Amelina, Edward McKone, Rebecca Cosgriff

Publikováno v: Journal of Cystic Fibrosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b75eda855e8e457d19986637bf21330
https://pubmed.ncbi.nlm.nih.gov/33941502

The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) influences promoter binding.

Autor: Takahito Kashiwagi, Bo Wah Leung, Tao Deng, Hualan Chen, George G Brownlee

Publikováno v: PLoS ONE, Vol 4, Iss 5, p e5473 (2009)

The RNA polymerase of influenza virus is a heterotrimeric complex of PB1, PB2 and PA subunits which cooperate in the transcription and replication of the viral genome. Previous research has shown that the N-terminal region of the PA subunit of influe

Externí odkaz: https://doaj.org/article/ba1e21f20b134482937c0358447b9a6e

P224 The UK clinical trials accelerator platform

Autor: L. Allen, E. Cousins, C. Round, R. Brendell, Keith G. Brownlee

Publikováno v: Journal of Cystic Fibrosis. 19:S119-S120

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e81ffe647b5e83a67c1a78144abf531
https://doi.org/10.1016/s1569-1993(20)30558-0