Výsledky vyhledávání - "Fyyaz, Siddiqui"

Akademický článek

First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation

Autor: Fyyaz Siddiqui, Denis Gallagher, Hannah Shuster-Hyman, Lianet Lopez, Andrée Gauthier-Fisher, Clifford L Librach

Publikováno v: Journal of Inflammation, Vol 20, Iss 1, Pp 1-17 (2023)

Abstract Background The Kynurenine Pathway (KP) of tryptophan degradation and glutamate toxicity is implicated in several neurological disorders, including depression. The therapeutic potential of mesenchymal stromal cells (MSC), owing to their well

Externí odkaz: https://doaj.org/article/032d05b5794145f59802b995ec826733

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Time course and mechanistic analysis of human umbilical cord perivascular cell mitigation of lipopolysaccharide-induced systemic and neurological inflammation

Autor: Hannah, Shuster-Hyman, Fyyaz, Siddiqui, Denis, Gallagher, Andrée, Gauthier-Fisher, Clifford L, Librach

Publikováno v: Cytotherapy. 25:125-137

Because of their potent immunomodulatory and anti-inflammatory properties, mesenchymal stromal cells are a major focus in the field of stem cell therapy. However, the precise mechanisms underlying this are not entirely understood. Human umbilical cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7dd428ddd12e2216ba3492b78aa92d
https://doi.org/10.1016/j.jcyt.2022.10.014

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Mesenchymal Stromal Cells Modulate Peripheral Stress-Induced Innate Immune Activation Indirectly Limiting the Emergence of Neuroinflammation-Driven Depressive and Anxiety-like Behaviors

Autor: Maxwell Charlat, Andrée Gauthier-Fisher, Fyyaz Siddiqui, Joseph Fish, Clifford Librach, Siddiq Moolla, Emaan Chaudry, Denis Gallagher

Publikováno v: Biological Psychiatry. 86:712-724

Background Hyperactivation of innate immunity has been implicated in the etiology of mood disorders, including major depressive disorder (MDD). Mesenchymal stromal cells (MSCs) have demonstrated potent immunomodulatory capabilities in the context of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea23965fec50eaf4412cb658856a359
https://doi.org/10.1016/j.biopsych.2019.07.015

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Decorin over-expression by decidual cells in preeclampsia: a potential blood biomarker

Autor: Genevieve Eastabrook, Karen Nygard, Barbra de Vrijer, Victor K. M. Han, Pinki Nandi, Gannareddy V. Girish, Peeyush K. Lala, Mohammad Fyyaz Siddiqui

Publikováno v: American journal of obstetrics and gynecology. 215(3)

Background Decorin, a leucine-rich proteoglycan that is produced by decidual cells, limits invasion and endovascular differentiation of extravillous trophoblast cells during early placentation by binding to multiple tyrosine kinase receptors, in part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d2a3e32768575da542977d1cb83f62
https://pubmed.ncbi.nlm.nih.gov/27001218

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Restraint of Trophoblast Invasion of the Uterus by Decorin: Role in Pre-eclampsia

Autor: Peeyush K. Lala, Pinki Nandi, Mohammad Fyyaz Siddiqui

Publikováno v: American journal of reproductive immunology (New York, N.Y. : 1989). 75(3)

Decorin (DCN) is a leucine-rich, TGF-β binding proteoglycan produced by mesenchymal cells including chondrocytes, dermal fibroblasts, and uterine decidual cells. It exerts multiple physiological functions including collagen fibrillogenesis, myogenes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb559a69ec2716b86ef09d9ab274a7d
https://pubmed.ncbi.nlm.nih.gov/26554635

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