Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Fyodor D. Urnov"'
Autor:
Mohamed Abou-el-Enein, Aris Angelis, Frederick R. Appelbaum, Nancy C. Andrews, Susan E. Bates, Arlene S. Bierman, Malcolm K. Brenner, Marina Cavazzana, Michael A. Caligiuri, Hans Clevers, Emer Cooke, George Q. Daley, Victor J. Dzau, Lee M. Ellis, Harvey V. Fineberg, Lawrence S.B. Goldstein, Stephen Gottschalk, Margaret A. Hamburg, Donald E. Ingber, Donald B. Kohn, Adrian R. Krainer, Marcela V. Maus, Peter Marks, Christine L. Mummery, Roderic I. Pettigrew, Joni L. Rutter, Sarah A. Teichmann, Andre Terzic, Fyodor D. Urnov, David A. Williams, Jedd D. Wolchok, Mark Lawler, Cameron J. Turtle, Gerhard Bauer, John P.A. Ioannidis
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 11-14 (2021)
Externí odkaz:
https://doaj.org/article/c3fa45c6e32349f68ffd7fcab701dc16
Autor:
Jennifer R. Hamilton, Elizabeth C. Stahl, Connor A. Tsuchida, Enrique Lin-Shiao, C. Kimberly Tsui, Kathleen Pestal, Holly K. Gildea, Lea B. Witkowsky, Erica A. Moehle, Shana L. McDevitt, Matthew McElroy, Amanda Keller, Iman Sylvain, Ariana Hirsh, Alison Ciling, Alexander J. Ehrenberg, Bradley R. Ringeisen, Garth Huberty, Fyodor D. Urnov, Petros Giannikopoulos, Jennifer A. Doudna, IGI SARS-CoV-2 Consortium
Publikováno v:
PLoS ONE, Vol 16, Iss 8 (2021)
Saliva is an attractive specimen type for asymptomatic surveillance of COVID-19 in large populations due to its ease of collection and its demonstrated utility for detecting RNA from SARS-CoV-2. Multiple saliva-based viral detection protocols use a d
Externí odkaz:
https://doaj.org/article/250fe7c14c81427f8666bd5d2e84261b
Autor:
Elizabeth C. Stahl, Allan R. Gopez, Connor A. Tsuchida, Vinson B. Fan, Erica A. Moehle, Lea B. Witkowsky, Jennifer R. Hamilton, Enrique Lin-Shiao, Matthew McElroy, Shana L. McDevitt, Alison Ciling, C. Kimberly Tsui, Kathleen Pestal, Holly K. Gildea, Amanda Keller, Iman A. Sylvain, Clara Williams, Ariana Hirsh, Alexander J. Ehrenberg, Rose Kantor, Matthew Metzger, Kara L. Nelson, Fyodor D. Urnov, Bradley R. Ringeisen, Petros Giannikopoulos, Jennifer A. Doudna, IGI Testing Consortium
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Clinical and surveillance testing for the SARS-CoV-2 virus relies overwhelmingly on RT-qPCR-based diagnostics, yet several popular assays require 2–3 separate reactions or rely on detection of a single viral target, which adds significant time, cos
Externí odkaz:
https://doaj.org/article/8b3699807c8348d7aa2a3fafef2c5562
Autor:
John E. Lazar, Sandra Stehling-Sun, Vivek Nandakumar, Hao Wang, Daniel R. Chee, Nicholas P. Howard, Reyes Acosta, Douglass Dunn, Morgan Diegel, Fidencio Neri, Andres Castillo, Sean Ibarrientos, Kristen Lee, Ninnia Lescano, Ben Van Biber, Jemma Nelson, Jessica Halow, Richard Sandstrom, Daniel Bates, Fyodor D. Urnov, Alister P.W. Funnell, John A. Stamatoyannopoulos
Publikováno v:
Cell Reports, Vol 31, Iss 8, Pp - (2020)
Summary: The human genome encodes millions of regulatory elements, of which only a small fraction are active within a given cell type. Little is known about the global impact of chromatin remodelers on regulatory DNA landscapes and how this translate
Externí odkaz:
https://doaj.org/article/db020382c20c4e37938ec33f5f948e59
Autor:
Nikoletta Psatha, Andreas Reik, Susan Phelps, Yuanyue Zhou, Demetri Dalas, Evangelia Yannaki, Dana N. Levasseur, Fyodor D. Urnov, Michael C. Holmes, Thalia Papayannopoulou
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 313-326 (2018)
In the present report, we carried out clinical-scale editing in adult mobilized CD34+ hematopoietic stem and progenitor cells (HSPCs) using zinc-finger nuclease-mediated disruption of BCL11a to upregulate the expression of γ-globin (fetal hemoglobin
Externí odkaz:
https://doaj.org/article/b6efc929ab464599a50a361672dec62b
Autor:
Kai-Hsin Chang, Sarah E. Smith, Timothy Sullivan, Kai Chen, Qianhe Zhou, Jason A. West, Mei Liu, Yingchun Liu, Benjamin F. Vieira, Chao Sun, Vu P. Hong, Mingxuan Zhang, Xiao Yang, Andreas Reik, Fyodor D. Urnov, Edward J. Rebar, Michael C. Holmes, Olivier Danos, Haiyan Jiang, Siyuan Tan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 137-148 (2017)
To develop an effective and sustainable cell therapy for sickle cell disease (SCD), we investigated the feasibility of targeted disruption of the BCL11A gene, either within exon 2 or at the GATAA motif in the intronic erythroid-specific enhancer, usi
Externí odkaz:
https://doaj.org/article/78e274bd1cdc4349b7f3df729d3543f4
Autor:
Ryan Forster, Kunitoshi Chiba, Lorian Schaeffer, Samuel G. Regalado, Christine S. Lai, Qing Gao, Samira Kiani, Henner F. Farin, Hans Clevers, Gregory J. Cost, Andy Chan, Edward J. Rebar, Fyodor D. Urnov, Philip D. Gregory, Lior Pachter, Rudolf Jaenisch, Dirk Hockemeyer
Publikováno v:
Stem Cell Reports, Vol 2, Iss 6, Pp 838-852 (2014)
Genetically engineered human pluripotent stem cells (hPSCs) have been proposed as a source for transplantation therapies and are rapidly becoming valuable tools for human disease modeling. However, many applications are limited due to the lack of rob
Externí odkaz:
https://doaj.org/article/29251974b44c49fb94543dca7d398aa3
Autor:
Laurie H. Sanders, Josée Laganière, Oliver Cooper, Sally K. Mak, B. Joseph Vu, Y. Anne Huang, David E. Paschon, Malini Vangipuram, Ramya Sundararajan, Fyodor D. Urnov, J. William Langston, Philip D. Gregory, H. Steve Zhang, J. Timothy Greenamyre, Ole Isacson, Birgitt Schüle
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 381-386 (2014)
Parkinson's disease associated mutations in leucine rich repeat kinase 2 (LRRK2) impair mitochondrial function and increase the vulnerability of induced pluripotent stem cell (iPSC)-derived neural cells from patients to oxidative stress. Since mitoch
Externí odkaz:
https://doaj.org/article/d505d3408a924944819f08f5874cf168
Autor:
Fyodor D. Urnov
Publikováno v:
New England Journal of Medicine. 382:481-484
New Tool for Correcting Mutations Protein engineering has yielded a new, potent tool — in the form of a chimeric enzyme — for correcting genetic mutations. Proof of principle that this enzyme can c...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d2242b430645e23315b71a22d1ac68
https://doi.org/10.1056/nejmcibr1914271
https://doi.org/10.1056/nejmcibr1914271