Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Fyodor D Urnov"'
Autor:
Laura Packel, Arthur Reingold, Lauren Hunter, Shelley Facente, Yi Li, Anna Harte, Guy Nicolette, Fyodor D Urnov, Michael Lu, Maya Petersen, IGI Testing Consortium
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245765 (2021)
BackgroundColleges and universities across the country are struggling to develop strategies for effective control of COVID-19 transmission as students return to campus.Methods and findingsWe conducted a prospective cohort study with students living o
Externí odkaz:
https://doaj.org/article/a0ef1506f132441bb3e20a13542d1790
Autor:
Alexander J Ehrenberg, Erica A Moehle, Cara E Brook, Andrew H Doudna Cate, Lea B Witkowsky, Rohan Sachdeva, Ariana Hirsh, Kerrie Barry, Jennifer R Hamilton, Enrique Lin-Shiao, Shana McDevitt, Luis Valentin-Alvarado, Kaitlyn N Letourneau, Lauren Hunter, Amanda Keller, Kathleen Pestal, Phillip A Frankino, Andrew Murley, Divya Nandakumar, Elizabeth C Stahl, Connor A Tsuchida, Holly K Gildea, Andrew G Murdock, Megan L Hochstrasser, Elizabeth O'Brien, Alison Ciling, Alexandra Tsitsiklis, Kurtresha Worden, Claire Dugast-Darzacq, Stephanie G Hays, Colin C Barber, Riley McGarrigle, Emily K Lam, David C Ensminger, Lucie Bardet, Carolyn Sherry, Anna Harte, Guy Nicolette, Petros Giannikopoulos, Dirk Hockemeyer, Maya Petersen, Fyodor D Urnov, Bradley R Ringeisen, Mike Boots, Jennifer A Doudna, IGI SARS-CoV-2 Testing Consortium
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251296 (2021)
Regular surveillance testing of asymptomatic individuals for SARS-CoV-2 has been center to SARS-CoV-2 outbreak prevention on college and university campuses. Here we describe the voluntary saliva testing program instituted at the University of Califo
Externí odkaz:
https://doaj.org/article/336066b4b23e4529865ab446851e9116
Autor:
Elizabeth C Stahl, Allan R Gopez, Connor A Tsuchida, Vinson B Fan, Erica A Moehle, Lea B Witkowsky, Jennifer R Hamilton, Enrique Lin-Shiao, Matthew McElroy, Shana L McDevitt, Alison Ciling, C Kimberly Tsui, Kathleen Pestal, Holly K Gildea, Amanda Keller, Iman A Sylvain, Clara Williams, Ariana Hirsh, Alexander J Ehrenberg, Rose Kantor, Matthew Metzger, Kara L Nelson, Fyodor D Urnov, Bradley R Ringeisen, Petros Giannikopoulos, Jennifer A Doudna, IGI Testing Consortium
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0258263 (2021)
Clinical and surveillance testing for the SARS-CoV-2 virus relies overwhelmingly on RT-qPCR-based diagnostics, yet several popular assays require 2-3 separate reactions or rely on detection of a single viral target, which adds significant time, cost,
Externí odkaz:
https://doaj.org/article/3053a4e5270e4f818e1a3cdef07b77fe
Autor:
Jennifer R Hamilton, Elizabeth C Stahl, Connor A Tsuchida, Enrique Lin-Shiao, C Kimberly Tsui, Kathleen Pestal, Holly K Gildea, Lea B Witkowsky, Erica A Moehle, Shana L McDevitt, Matthew McElroy, Amanda Keller, Iman Sylvain, Ariana Hirsh, Alison Ciling, Alexander J Ehrenberg, Bradley R Ringeisen, Garth Huberty, Fyodor D Urnov, Petros Giannikopoulos, Jennifer A Doudna, IGI SARS-CoV-2 Consortium
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255690 (2021)
Saliva is an attractive specimen type for asymptomatic surveillance of COVID-19 in large populations due to its ease of collection and its demonstrated utility for detecting RNA from SARS-CoV-2. Multiple saliva-based viral detection protocols use a d
Externí odkaz:
https://doaj.org/article/6ecb7579908e414cb8a938c86fd07cef
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16961 (2011)
Sequences governing RNA splicing are difficult to study in situ due to the great difficulty of traditional targeted mutagenesis. Zinc-finger nuclease (ZFN) technology allows for the rapid and efficient introduction of site-specific mutations into mam
Externí odkaz:
https://doaj.org/article/6fb9387b632942339d6e78b139477598
Autor:
Fyodor D. Urnov
Publikováno v:
New England Journal of Medicine. 382:481-484
New Tool for Correcting Mutations Protein engineering has yielded a new, potent tool — in the form of a chimeric enzyme — for correcting genetic mutations. Proof of principle that this enzyme can c...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d2242b430645e23315b71a22d1ac68
https://doi.org/10.1056/nejmcibr1914271
https://doi.org/10.1056/nejmcibr1914271
Autor:
Roderic I. Pettigrew, Sarah A. Teichmann, Nancy C. Andrews, Arlene S. Bierman, Frederick R. Appelbaum, Cameron J. Turtle, Emer Cooke, John P. A. Ioannidis, Susan E. Bates, Joni L. Rutter, Marcela V. Maus, Hans Clevers, Gerhard Bauer, Marina Cavazzana, Adrian R. Krainer, Harvey V. Fineberg, Michael A. Caligiuri, Donald E. Ingber, Donald B. Kohn, George Q. Daley, Stephen Gottschalk, Jedd D. Wolchok, Victor J. Dzau, David R. Williams, Mohamed Abou-El-Enein, Lawrence S.B. Goldstein, Andre Terzic, Mark Lawler, Lee M. Ellis, Fyodor D. Urnov, Margaret A. Hamburg, Christine L. Mummery, Malcolm K. Brenner, Aris Angelis, Peter W. Marks
Publikováno v:
Abou-el-Enein, M, Angelis, A, Appelbaum, F R, Andrews, N C, Bates, S E, Bierman, A S, Brenner, M K, Cavazzana, M, Caligiuri, M A, Clevers, H, Cooke, E, Daley, G Q, Dzau, V J, Ellis, L M, Fineberg, H V, Goldstein, L S B, Gottschalk, S, Hamburg, M A, Ingber, D E, Kohn, D B, Krainer, A R, Maus, M V, Marks, P, Mummery, C L, Pettigrew, R I, Rutter, J L, Teichmann, S A, Terzic, A, Urnov, F D, Williams, D A, Wolchok, J D, Lawler, M, Turtle, C J, Bauer, G & Ioannidis, J P A 2021, ' Evidence generation and reproducibility in cell and gene therapy research : A call to action ', Molecular Therapy-Methods and Clinical Development, vol. 22, pp. 11-14 . https://doi.org/10.1016/j.omtm.2021.06.012
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss, Pp 11-14 (2021)
Molecular therapy. Methods & clinical development, 22, 11-14. Nature Publishing Group
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss, Pp 11-14 (2021)
Molecular therapy. Methods & clinical development, 22, 11-14. Nature Publishing Group
Editorial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338aacefe123d43d370d2aa733485eb8
Autor:
Fyodor D, Urnov
Publikováno v:
Nature genetics
Genome editing has therapeutic potential for treating genetic diseases and cancer. However, the currently most practicable approaches rely on the generation of DNA double-strand breaks (DSBs), which can give rise to a poorly characterized spectrum of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56332d052eb1ef2d0d4af98dee2fc4dc
https://pubmed.ncbi.nlm.nih.gov/33846636
https://pubmed.ncbi.nlm.nih.gov/33846636
Autor:
Yasaman Ataei, Larry Park, D. James Surmeier, B. Joseph Vu, Seung Kwak, Richard T. Surosky, Anand Narayanan, David A. Shivak, Josee Laganiere, Christer Halldin, Andrea Varrone, Matthew C. Mendel, Karsten Tillack, Lei Zhang, Bryan Zeitler, Dmitry Guschin, Lexi Kopan, Sarah J. Hinkley, Kimberly Marlen, Jocelynn R. Pearl, Qi Yu, Taneli Heikkinen, Annette Gärtner, Yalda Sedaghat, Christina Thiede, Miklós Tóth, Jennifer M. Cherone, David Paschon, Jyothisri Kondapalli, Andrea E. Kudwa, Ladislav Mrzljak, Rainier Amora, Kimmo Lehtimäki, Edward J. Rebar, Lenke Tari, Ignacio Munoz-Sanjuan, Jeffrey C. Miller, Sylvie Ramboz, Marie Svedberg, Steven Froelich, Irina Ankoudinova, Philip D. Gregory, Stephen Lam, Michelle Day, Jonathan Bard, Hoang Oanh B. Nguyen, Fyodor D. Urnov, Davis Li, Jenny Haggkvist, H. Steve Zhang, Guijuan Qiao
Publikováno v:
Nature Medicine. 25:1131-1142
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since normal HTT is thought to be importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d19307c1ae395108f0cf1b74fb590fb6
https://doi.org/10.1038/s41591-019-0478-3
https://doi.org/10.1038/s41591-019-0478-3