Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress

Autor: Katie A. O’Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia, James Armitage, Luke W. Thomas, Fynn N. Krause, Lucas A. Maddalena, Ian Francis, Stefan Kavanagh, Dominic P. Williams, Margaret Ashcroft, Julian L. Griffin, Jonathan J. Lyon, Andrew J. Murray

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)

Abstract Background Tissue hypoxia is a key feature of several endemic hepatic diseases, including alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe metabolic challenge on the liver, potentially disrupting i

Externí odkaz: https://doaj.org/article/e6fa613deccb4bec8cc1aae51e72dedf

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis

Autor: Graeme Davies, Julian L. Griffin, Anna Whitehead, Amanda D. V. MacCannell, Jürgen E. Schneider, Christopher Church, Steven A. Murfitt, Jason L. Scragg, Andrew J. Murray, Samuel Virtue, Fynn N. Krause, Edward Boateng, Jack Garnham, Amy Moran, Ben D. McNally, Antonio Vidal-Puig, Lee D. Roberts, Klaus K. Witte, James Dodgson, John Wright

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)

Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35c35aa1f5dc2a16de5ff5b842bce2a
http://europepmc.org/articles/PMC7998027

The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination

Autor: Christopher E McMurran, Julian L. Griffin, Ginez A. Gonzalez, Robin J.M. Franklin, Denise C. Fitzgerald, Chao Zhao, Clare A. Jones, Alerie Guzman de la Fuente, Claire Hollins, Markus M. Heimesaat, Adam Young, Rosana Penalva, John Falconer, Ofra Ben Menachem-Zidon, Fynn N. Krause, Yvonne Dombrowski

Publikováno v: McMurran, C E, Guzman de la Fuente, A, Penalva, R, Ben Menachem-Zidon, O, Dombrowski, Y, Falconer, J, Gonzalez, G A, Zhao, C, Krause, F N, Young, A M H, Griffin, J L, Jones, C A, Hollins, C, Heimesaat, M M, Fitzgerald, D C & Franklin, R J M 2019, ' The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 50, pp. 25311 . https://doi.org/10.1073/pnas.1905787116
Proc Natl Acad Sci U S A

The microbiota is now recognized as a key influence on the host immune response in the central nervous system (CNS). As such, there has been some progress toward therapies that modulate the microbiota with the aim of limiting immune-mediated demyelin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde6ab34854ff26266d493559fa1847e
https://pure.qub.ac.uk/en/publications/the-microbiota-regulates-murine-inflammatory-responses-to-toxininduced-cns-demyelination-but-has-minimal-impact-on-remyelination(59cba7d8-3531-4638-af50-5338ac26281c).html