Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Fxr, farnesoid X receptor"'
Autor:
Niani Tiaye Bailey, Bilon Khambu, Gang Liu, Sophia Blessinger, Katherine Byrnes, Russell Scaife
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)
Metabolic homeostasis requires dynamic catabolic and anabolic processes. Autophagy, an intracellular lysosomal degradative pathway, can rewire cellular metabolism linking catabolic to anabolic processes and thus sustain homeostasis. This is especiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58c0ac6db641c550d04c5a5c6ba5a1a
https://doi.org/10.1016/j.apsb.2021.07.021
https://doi.org/10.1016/j.apsb.2021.07.021
Publikováno v:
Journal of Advanced Research
Graphical abstract
Introduction Non-alcoholic fatty liver disease (NAFLD) results from increased hepatic total cholesterol (TC) and total triglyceride (TG) accumulation. In our previous study, we found that rats treated with hyperoside became re
Introduction Non-alcoholic fatty liver disease (NAFLD) results from increased hepatic total cholesterol (TC) and total triglyceride (TG) accumulation. In our previous study, we found that rats treated with hyperoside became re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2bd34a875a308c3012404fcb1667cc
https://doi.org/10.1016/j.jare.2021.06.001
https://doi.org/10.1016/j.jare.2021.06.001
Autor:
Michael Goedken, Grace L. Guo, Brian Buckley, Bo Kong, Anita M. Brinker, Rulaiha Elizabeth Taylor, Daniel Rizzolo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3847-3856 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Bile acids (BAs) are amphipathic molecules important for metabolism of cholesterol, absorption of lipids and lipid soluble vitamins, bile flow, and regulation of gut microbiome. There are over 30 different BA species known to exist in humans and mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3528a74d648335c5d6495523367f011
http://www.sciencedirect.com/science/article/pii/S2211383521001891
http://www.sciencedirect.com/science/article/pii/S2211383521001891
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 973-997 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims The functions of the liver and the intestine are closely tied in both physiological and pathologic conditions. The gut microbiota (GM) often cause deleterious effects during hepatic pathogenesis. Autophagy is essential for liver hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5847c5c25a4c55b7146f469ae9e2e369
http://www.sciencedirect.com/science/article/pii/S2352345X20301740
http://www.sciencedirect.com/science/article/pii/S2352345X20301740
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1519-1539 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Nonalcoholic fatty liver disease comprises a wide spectrum of liver injuries from simple steatosis to steatohepatitis and cirrhosis. Nonalcoholic steatohepatitis (NASH) is defined when liver steatosis is associated with inflammation, hepatocyte damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f63dcdb7df5791629395e4c7c05eb5e
http://www.sciencedirect.com/science/article/pii/S2352345X21000187
http://www.sciencedirect.com/science/article/pii/S2352345X21000187
Autor:
Hugo R. de Jonge, Kelly F. Meijsen, Johan W. Jonker, Pauline T. Ikpa, Marcel J. C. Bijvelds, Natascha D.A. Nieuwenhuijze, Henkjan J. Verkade, Marcela Doktorova
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 47-60 (2020)
Cellular and molecular gastroenterology and hepatology, 9(1), 47-60. HANLEY & BELFUS-ELSEVIER INC
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 9(1), 47-60. Elsevier Inc.
Cellular and molecular gastroenterology and hepatology, 9(1), 47-60. HANLEY & BELFUS-ELSEVIER INC
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 9(1), 47-60. Elsevier Inc.
Background & Aims The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19. Because cystic fibrosis (CF) is associated with intestinal dysbiosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8055077ad92962df0418235c07c4f6f5
https://research.rug.nl/en/publications/34117206-9fb3-4deb-93c6-97b1fd66ffab
https://research.rug.nl/en/publications/34117206-9fb3-4deb-93c6-97b1fd66ffab
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 19-32 (2020)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic metabolism. The gut microbiome, the collection of microorganisms in the gastrointestinal tract, can alter the metabolic outcome of pharmaceuticals, environmental toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511b159fb05311b8d1af4e8394064073
http://www.sciencedirect.com/science/article/pii/S2211383519309736
http://www.sciencedirect.com/science/article/pii/S2211383519309736
Autor:
Veronika Voronova, Kirill Peskov, Victor Sokolov, Amani Al-Khaifi, Chanchal Kumar, Mats Rudling, Gabriel Helmlinger, Sara Straniero, Bo Angelin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 149-170 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Disturbances of the enterohepatic circulation of bile acids (BAs) are seen in a number of clinically important conditions, including metabolic disorders, hepatic impairment, diarrhea, and gallstone disease. To facilitate the explora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e7c1c53415ffd191bc13602d3d22bb
http://www.sciencedirect.com/science/article/pii/S2352345X20300266
http://www.sciencedirect.com/science/article/pii/S2352345X20300266
Autor:
Stan F.J. van de Graaf, Reinout L.P. Roscam Abbing, Joanne M. Donkers, Michel van Weeghel, Johannes H.M. Levels, Ronald P.J. Oude Elferink, Anita Boelen, Alfred H. Schinkel
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 451-466 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 10(3), 451-466. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 10(3), 451-466. Elsevier Inc.
Background & Aims Bile acids are important metabolic signaling molecules. Bile acid receptor activation promotes body weight loss and improves glycemic control. The incretin hormone GLP-1 and thyroid hormone activation of T4 to T3 have been suggested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4c156a368ab5b8e88ab5658e7840fc
http://www.sciencedirect.com/science/article/pii/S2352345X20300539
http://www.sciencedirect.com/science/article/pii/S2352345X20300539
Autor:
Justine Gillard, Laure-Alix Clerbaux, Bart Staels, Anne Tailleux, Isabelle Leclercq, Laure B. Bindels, Maxime Nachit, Christine Sempoux
Publikováno v:
JHEP reports, vol. 4, no. 1, pp. 100387
JHEP Reports, Vol 4, Iss 1, Pp 100387-(2022)
JHEP reports, Vol. 4, no.1, p. 100387 [1-13] (2022)
JHEP Reports
JHEP Reports, Vol 4, Iss 1, Pp 100387-(2022)
JHEP reports, Vol. 4, no.1, p. 100387 [1-13] (2022)
JHEP Reports
Background & Aims Through FXR and TGR5 signaling, bile acids (BAs) modulate lipid and glucose metabolism, inflammation and fibrosis. Hence, BAs returning to the liver after enteric secretion, modification and reabsorption may contribute to the pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f803f3cd8976e73d533d8b1885ead5
https://serval.unil.ch/notice/serval:BIB_8BED7E41CA16
https://serval.unil.ch/notice/serval:BIB_8BED7E41CA16
