Zobrazeno 1 - 10 of 78 pro vyhledávání: '"Fuzhong, Qin"'
1
Akademický článek
SGLT2 inhibitor ertugliflozin decreases elevated intracellular sodium, and improves energetics and contractile function in diabetic cardiomyopathy
Autor: Dominique Croteau, Tomas Baka, Sara Young, Huamei He, Jordan M. Chambers, Fuzhong Qin, Marcello Panagia, David R. Pimentel, James A. Balschi, Wilson S. Colucci, Ivan Luptak
Publikováno v: Biomedicine & Pharmacotherapy, Vol 160, Iss , Pp 114310- (2023)
Background: Elevated myocardial intracellular sodium ([Na+]i) was shown to decrease mitochondrial calcium ([Ca2+]MITO) via mitochondrial sodium/calcium exchanger (NCXMITO), resulting in decreased mitochondrial ATP synthesis. The sodium-glucose co-tra
Externí odkaz: https://doaj.org/article/ddbf2c50d47847a383f78995232ae6e7
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2
Akademický článek
Effects of Sodium‐Glucose Linked Transporter 2 Inhibition With Ertugliflozin on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice
Autor: Dominique Croteau, Ivan Luptak, Jordan M. Chambers, Ion Hobai, Marcello Panagia, David R. Pimentel, Deborah A. Siwik, Fuzhong Qin, Wilson S. Colucci
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 13 (2021)
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Externí odkaz: https://doaj.org/article/cb89ff2bb7ca44b79b60b9cd0761c0c1
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4
Akademický článek
Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge
Autor: Edward J. Miller, Timothy Calamaras, Aly Elezaby, Aaron Sverdlov, Fuzhong Qin, Ivan Luptak, Ke Wang, Xinxin Sun, Andrea Vijay, Dominique Croteau, Markus Bachschmid, Richard A. Cohen, Kenneth Walsh, Wilson S. Colucci
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundMyocardial hypertrophy and dysfunction are key features of metabolic heart disease due to dietary excess. Metabolic heart disease manifests primarily as diastolic dysfunction but may progress to systolic dysfunction, although the mechanism
Externí odkaz: https://doaj.org/article/5e3d41148a354572bb88926c7948ce0c
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5
Akademický článek
Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet‐Induced Metabolic Heart Disease
Autor: Aaron L. Sverdlov, Aly Elezaby, Fuzhong Qin, Jessica B. Behring, Ivan Luptak, Timothy D. Calamaras, Deborah A. Siwik, Edward J. Miller, Marc Liesa, Orian S. Shirihai, David R. Pimentel, Richard A. Cohen, Markus M. Bachschmid, Wilson S. Colucci
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundMitochondrial reactive oxygen species (ROS) are associated with metabolic heart disease (MHD). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD. Methods and
Externí odkaz: https://doaj.org/article/cca659c2f7ae4f23b72a454022eded52
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6
Abstract 10678: Butyrate Improves Energetics, Diastolic Function and Contractile Reserve in Hearts from Mice with Hypertrophic Cardiomyopathy Due to Myosin R403Q Mutation
Autor: Tomas Baka, Dominique Croteau, Jordan Chambers, Huamei He, James Balschi, Fuzhong Qin, Wilson S Colucci, David Pimentel, Ivan Luptak
Publikováno v: Circulation. 144
Background: It is well established that hearts with hypertrophic cardiomyopathy (HCM) are energy starved as reflected by a decreased phosphocreatine to ATP ratio that corresponds to increased ADP and decreased free energy of ATP hydrolysis (ΔG ~ATP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a69152f8c45ec12770139a6a406f6b17
https://doi.org/10.1161/circ.144.suppl_1.10678
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7
Effects of Sodium‐Glucose Linked Transporter 2 Inhibition With Ertugliflozin on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice
Autor: Ion A. Hobai, Wilson S. Colucci, Dominique Croteau, Deborah A. Siwik, Jordan M. Chambers, Fuzhong Qin, Marcello Panagia, Ivan Luptak, David R. Pimentel
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16203839faa370c679548b749eaa129
http://europepmc.org/articles/PMC8403324
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8
Abstract 16641: The SGLT2 Inhibitor Ertugliflozin Induces Oxidative Phosphorylation Gene Expression and Improves Systolic Function Independent of Diabetes in Mice
Autor: Wilson S. Colucci, Jordan M. Chambers, David R. Pimentel, Deborah A. Siwik, Ivan Luptak, Fuzhong Qin, Ion A. Hobai, Jena B Goodman, Marcello Panagia, Dominique Croteau
Publikováno v: Circulation. 142
Background: Inhibitors of sodium glucose linked transporter 2 (SGLT2i) improve heart failure (HF) outcomes in patients independent of diabetes. While animal studies suggest SGLT2i improve cardiac metabolism, the effect of SGLT2i on mitochondrial func
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::745c6cf907599986b5cff1d79bd630c2
https://doi.org/10.1161/circ.142.suppl_3.16641
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9
Differential Effects of Sacubitril/Valsartan on Diastolic Function in Mice With Obesity-Related Metabolic Heart Disease
Autor: Fuzhong Qin, Deborah A. Siwik, David R. Pimentel, Ivan Luptak, Marcello Panagia, Dominique Croteau, Jordan M. Chambers, Wilson S. Colucci, Ethan Kallick
Publikováno v: JACC. Basic to translational science. 5(9)
Highlights •MHD associated with obesity, diabetes, and/or metabolic syndrome is an important precursor of HFpEF. •Mice fed a HFHS diet develop MHD with myocardial hypertrophy, fibrosis, diastolic dysfunction, and impaired energetics. •Mice on H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860f711e67b12791891a81545cd7f650
https://pubmed.ncbi.nlm.nih.gov/33016957
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10
Preclinical Alterations in Myocardial Microstructure in People with Metabolic Syndrome
Autor: Deepa M. Gopal, Nir Ayalon, Jennifer E. Ho, Pranoti Hiremath, Harpaul Sandhu, Wilson S. Colucci, Fuzhong Qin, Jill Downing, Youssef Rahban, Alejandro J. Perez, Susan Cheng
Publikováno v: Obesity. 25:1516-1522
OBJECTIVE Metabolic syndrome (MetS) can lead to myocardial fibrosis, diastolic dysfunction, and eventual heart failure. This study evaluated alterations in myocardial microstructure in people with MetS by using a novel algorithm to characterize ultra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e206e446b70033b3acb8e6c5258a542
https://doi.org/10.1002/oby.21936
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